Tessera
Folgen

Agnes Noy

@agnesnoy.bsky.social

Senior Lecturer at the University of York. DNA, protein-DNA, biophysics, modeling, supercoiling, and much more

14 Posts85 Follower66 Folgt
Alice Pyne@alicepyne.bsky.social · 4mo ago

Supercoiling not only brings DNA to life (and makes it dance) but also changes how key proteins such as #CRISPR interact with it. Thanks @qmsmith.bsky.social for the brilliant collaboration, Sylvia for developing an amazing new #imageanalysis pipeline & @eddierollins.bsky.social for beautiful #AFM.

CryoEM and AFM images of DNA minicircles bound to CRISPR Cas9
Quentin Smith@qmsmith.bsky.social · 4mo ago

1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics

Grainger Lab@graingerlab.bsky.social · 4mo ago

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com www.jobs.ac.uk/job/DQY475/r...

Research Fellow (Postdoctoral) at University of Birmingham

Explore an exciting academic career as a Research Fellow (Postdoctoral). Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk

Agnes Noy@agnesnoy.bsky.social · 9mo ago

Would you like to fight against antimicrobial resistance (AMR) developing antibiotics? Apply to the PhD opportunity below and come to York. Collaboration with colegroupncl.bsky.social, @dghilarov.bsky.social and Inspiralis Ltd. Fully funded via DiMeN DTP 💡 www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Computational Drug Discovery Targeting DNA Gyrase to Tackle Antimicrobial Resistance at University of York on FindAPhD.com

PhD Project - MRC DiMeN Doctoral Training Partnership: Computational Drug Discovery Targeting DNA Gyrase to Tackle Antimicrobial Resistance at University of York, listed on FindAPhD.com

findaphd.com

Agnes Noy@agnesnoy.bsky.social · last yr.

This is one of the conferences where I have genuinely learned more. Delighted to contribute to this vision article.

DDame lab at Leiden University@damelab.bsky.social · last yr.

In @molecularmicro.bsky.social: two special issues on Prokaryotic Chromosome Organization. Many excellent contributions, including a vision article: 'Future directions of the Prokaryotic Chromosome Field', outcome of BioPhyChrom 2023 @biophychrom.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Agnes Noy@agnesnoy.bsky.social · last yr.

Were you interested in our last paper published in Phys. Rev. Lett. (with Matthew Burman at the University of York) but found it too hard to follow? Then, look at the piece from @sciencex.bsky.social where it is explained in more plain terms with the help of Ingrid Fadelli

Science X / Phys.org@sciencex.bsky.social · last yr.

Molecular simulations have unveiled how torsional stress influences supercoiled DNA, revealing that AT-rich sequences form bubbles more easily, facilitating genetic information access. doi.org/g83xvv

Agnes Noy@agnesnoy.bsky.social · 2y ago

Our last paper just appeared in Physical Review Letters. We studied how linear DNA is distorted by torsion and tension using all-atom simulations. Excellent work from Matthew Burman's EPSRC-funded PhD. Thanks to N8 CIR and HecBiosim for computational resources doi.org/10.1103/Phys... See thread 👇

Atomic Description of the Reciprocal Action between Supercoils and Melting Bubbles on Linear DNA

Although the mechanical response of DNA to physiological torsion and tension is well characterized, the detailed structures are not yet known. By using molecular dynamics simulations on linear DNA wit...

doi.org