The Schindler Lab
@agschindler.bsky.social
Research group @unituebingen.bsky.social. Interested in viral immune modulation and development of broad-spectrum antivirals | Group account
HIV-1 Vpr does more than degrade cellular proteins! Johanna and Carlos dug deeper and found that Vpr activates the transcription factor NFAT to reprogram T cells. Nearly half of Vpr-deregulated genes were NFAT-controlled, and NFAT inhibition eased Vpr-induced G2 arrest and reduced HIV-1 replication.
Very happy to have participated to the #RETROPATH2025 meeting in Tubingen: I had the pleasure to chair the last but great session yesterday! a lot of insights on #retroviruses in particular endoretroviruses! Thank you Michael Schindler and Daniel Sauter for the awsome programme!
Had an excellent time at this year’s #RetroPATH2025 meeting in Tübingen, Germany, talking about my work on #HIVcure. Many thanks to @agschindler.bsky.social and Daniel Sauter for hosting. Especially interesting was the variety of talks on #HERVs @goffinetlab.bsky.social @lstmnews.bsky.social
Last week, @ako98.bsky.social gave her first poster presentation at the #Retropath meeting in Tübingen, where I also presented the excellent work of João Côrte-Real. @agschindler.bsky.social and @sauterlab.bsky.social did a fantastic job organizing the meeting. #ProudPI #Retroviruses
We’re excited to welcome retrovirologists to the 34th RetroPATH Conference in Tübingen! Looking forward to inspiring talks and engaging discussions.
Excited to share our latest publication www.science.org/doi/10.1126/..., where we uncover a novel mechanism by which HIV-1 evades the host antiviral immune response.
HIV-1 manipulates CD96 on CD4+ T cells to subvert antiviral immunity
HIV-1 down-regulates CD96, revealing the role for this receptor in regulating the antiviral immune responses in CD4+ T cells.
science.org
A quick hii and we are now officially on Bluesky 🎉
Coming back from the 50th anniversary of #cshretro. Johanna presented two of her PhD projects and represented our group in discussions throughout the week. A great opportunity to share research and connect with the international retrovirology community!
Excited to share our latest collobarative study with the @dr_drae and Kaleta labs! Using scRNA-Seq–driven metabolic modeling, we identified phenformin & atpenin A5 as potent broad-spectrum antivirals targeting host metabolism. Out now: https://www.nature.com/articles/s42003-025-08148-y
Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses - Communications Biology
A metabolic modeling approach reveals druggable host cell pathways essential for viral replication across various viruses with minimal cytotoxicity. These findings highlight cellular metabolism as a promising target for antiviral therapy.
nature.com
🚨 Calling all retrovirologists Join us for RetroPATH 2025, one of the worldwide leading meetings in retrovirus research! Abstract submission and registration is open. 📍Tübingen, Germany | 📅 October 6–9, 2025 Register now! https://evis.events/event/469/ #RetroPATH #Retroviruses #HERV
Just wrapped up an amazing few days at the European Congress of Virology in Croatia. Great to connect with colleaques and see the lastest research developments. #ecv2025
Huge congrats to Rabea for successfully defending her PhD yesterday 🎉🎓
We are thrilled to announce that we will be hosting the next Retropath Conference in Tübingen together with the group of Daniel Sauter. Save the date and we can not wait to see you all there. #Retropath #Tübingen https://x.com/Retro_Path/status/1847556280858144985
Matteo took the stage at the Humboldt Networking Meeting #AvHNet to share his research! 🔬👏 https://x.com/MBosso92/status/1859670805204041800
🥳Natalia and Johanna representing our team at the HCV-Flavi conference this year. They are presenting their research on a small compound called C10 - a broadly acting #flavivirus inhibitor.
📢Find out more about this exciting project and how to apply here: http://www.eusv.eu/job-market/
The Schindler Lab@agschindler.bsky.social · 2y ago🔬 #Postdoc Opportunity in #AntiviralResearch! Join our team to explore broad-spectrum antiviral compounds to combat viruses like DENV, Influenza A, RSV, and SARS-CoV-2. Perfect for a driven scientist with a passion for #virology and #drugdevelopment.
🎉Congrats to Natalia for receiving the #AtheneGrant at the University of Tübingen! This grant will support her work on developing nanobodies to fight Dengue fever and aims to create new therapies that could neutralize all four Dengue serotypes. #DengueResearch #WomenInScience
Congratulations to our former student Sophia Kieferle on being awarded the MoBBEL price by the biochemists in Tübingen for her master thesis! She investigated Spike expression and release in primary cells upon BioNTech Corona vaccine treatment. Wishing her continued success!🚀
Today, Natalia and Raphaël are presenting their research projects at the #forschungstag2024 from the @bwstiftung. We are happy to hear more about innovative science in #badenwürttemberg. https://x.com/bwstiftung/status/1805517931096293793
Sadly, we are saying goodbye to our friend and colleague Sabina. We wish you all the best for your future and looking forward to see you around in Tübingen 😊
📢A real multitasker: in our latest #Review we are summarizing the variety of #HIV-1 Vpr functions in primary CD4+ T cells https://www.mdpi.com/1999-4915/16/3/420
HIV-1 Vpr Functions in Primary CD4+ T Cells
HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes. Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to exert various biological effects on the host cell upon delivery. In this way, Vpr contributes towards the establishment of a successful infection, as evidenced by the extent to which HIV-1 depends on this factor to achieve full pathogenicity in vivo. Although HIV infects various cell types in the host organism, CD4+ T cells are preferentially targeted since they are highly permissive towards productive infection, concomitantly bringing about the hallmark immune dysfunction that accompanies HIV-1 spread. The last several decades have seen unprecedented progress in unraveling the activities Vpr possesses in the host cell at the molecular scale, increasingly underscoring the importance of this viral component. Nevertheless, it remains controversial whether some of these advances bear in vivo relevance, since commonly employed cellular models significantly differ from primary T lymphocytes. One prominent example is the “established” ability of Vpr to induce G2 cell cycle arrest, with enigmatic physiological relevance in infected primary T lymphocytes. The objective of this review is to present these discoveries in their biological context to illustrate the mechanisms whereby Vpr supports HIV-1 infection in CD4+ T cells, whilst identifying findings that require validation in physiologically relevant models.
mdpi.com
🔬Looking forward to seeing you in #Vienna and discussing #Science with you! https://x.com/GesVirologie/status/1762735422977753371
Welcome Matteo! We are excited to have you as a new member in our team. Matteo has been awarded the #HumboldtResearchFellowship for Postdocs and will join our #Ebola team. He will focus on establishing the Ebola virus trVLP system in primary target cells.
Huge congratulations to Dr. Natalia Ruetalo on securing funding from the Baden-Württemberg Foundation. Together with Prof. Ulrich Rothbauer and @neyts_johan, she will be working on the development of #nanobodies that are able to neutralize all four subtypes of the #dengue virus.
Ever wondered about CD81 beyond HCV entry? Our latest study shows it's a negative regulator of NF-κB signaling: https://www.frontiersin.org/articles/10.3389/fcimb.2024.1338606/full.
Frontiers | CD81 suppresses NF-κB signaling and is downregulated in hepatitis C virus expressing cells
The tetraspanin CD81 is one of the main entry receptors for Hepatitis C virus, which is a major causative agent to develop liver cirrhosis and hepatocellular...
frontiersin.org
