Alexander Sever
@aimsever.bsky.social
Grad student in the Lewis E. Kay lab at the University of Toronto. Using #NMR to study protein structure & dynamics.
Really excited to have my work on the Caspase-11 non-canonical Inflammasome complex published today in @pnas.org! Check it out below 👇 www.pnas.org/doi/10.1073/...
The dynamic and heterogeneous structure of the non-canonical inflammasome | PNAS
Inflammasomes are high-molecular-weight complexes that play integral roles in the innate immune system, triggering an inflammatory cascade to prote...
pnas.org
Job Opening: Director of the NMR/MRI Program at the National High Magnetic Field Lab @nationalmaglab.bsky.social #NMRjobs #NMRchat 🧲 hr.fsu.edu/facultyjobs (Job ID: 62492) nationalmaglab.org/careers/job-...
Faculty Careers | Office of Human Resources
hr.fsu.edu
Professor Lewis E. Kay @lek-lab.bsky.social University of Toronto/SickKids, has been promoted to Companion of the Order of Canada, the highest level of the Order of Canada, for his pioneering biomolecular NMR research, and training a new generation of scientists www.gg.ca/en/appointme... #NMRchat 🧲
Order of Canada Appointees – June 26, 2026
Companions Michael Andrew Fox, C.C. Burnaby, British Columbia and New York, New York, United States of America
gg.ca
PhD position in NMR-based structural biology in the Reid Alderson lab at Helmholtz Munich, the Bavarian NMR Center www.bnmrz.org the Technical University of Munich, solution-state NMR, protein biochemistry & AI-based computational modeling, contact @reidalderson.bsky.social #NMRjobs #NMRchat 🧲
BNMRZ - Bayerisches NMR-Zentrum
bnmrz.org
Making invisible excited-state structures of pro-interleukin-18 visible by combining NMR and machine learning @PNAS.org
Making invisible excited-state structures of pro-interleukin-18 visible by combining NMR and machine learning
Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. SignificanceIn many cases accurate models of the low energy, most populated form of a protein’s three-dimensional structure can be rapidly determined using machine learning (ML) programs, such as AlphaFold. However, biomolecular function is often ...
dlvr.it
The dynamic and heterogeneous structure of the non-canonical inflammasome https://www.biorxiv.org/content/10.64898/2026.04.15.718739v1
Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen
We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD
Out now in EMBO J ahead of World #TB day! Our friends at the TB Drug Accelerator identified EtfD as a high-priority target for fast acting treatments so @courbongautier.bsky.social jumped into action. Our EtfD assay & struct are already being used to help find new therapeutics tinyurl.com/3cb2j5k9
John Rubinstein@johnrubinstein.bsky.social · last yr.EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment. But how does EtfD work? And how can you assay its activity? In his final PhD manuscript @courbongautier.bsky.social provides answers! www.biorxiv.org/content/10.1...
Now out! Methods for isotope labeling in mammalian cells for NMR studies of difficult-to-produce proteins onlinelibrary.wiley.com/doi/full/10....
Human cells for human proteins: Isotope labeling in mammalian cells in suspension for functional NMR studies
In biological and biomedical research, the focus progressively moves towards difficult human proteins, which often can only be expressed in higher eukaryotic cells. Nuclear magnetic resonance (NMR) c...
onlinelibrary.wiley.com
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve
Preprint, The BEST-HMBC-HMQC expt for pairing geminal methyl groups in Valine and Leucine side-chains. Ana P.A. Alva, Lucas Siemons, Ulric le Paige, Coline Wiame, Florence Cordier, Nicolas Wolff, Guillaume Bouvignies, Philippe Pelupessy, Fabien Ferrage chemrxiv.org/engage/chemr... #NMRchat #NMR 🧲
The BEST-HMBC-HMQC experiment for pairing geminal methyl groups in Valine and Leucine side-chains.
Methyl groups are essential probes for characterising interactions and dynamics in large proteins. HN-based triple-resonance NMR experiments are often too insensitive for methyl assignments, making a ...
chemrxiv.org
The helium recovery system is now fully functioning in Lumigen’s #NMR facility! With this system, helium will be captured, purified, and stored for reuse in our NMR facility and can be used for other instruments, such as mass spectrometers.
One like & I’ll migrate the Kay lab account to BlueSky!