AI drug discovery has a data problem. We're fixing it. At ALLOX, we've spent the last few years building something that didn't exist before: a platform that systematically maps functional hotspots at scale, measuring the effects of mutations on protein-protein interactions across the proteome.

Wow. Catalonia has more active clinical trials than the entirety of the UK or Germany. That's wild. From the latest @biocat.cat annual report.

The allosteric landscape of the Src kinase by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social www.science.org/doi/10.1126/...

The allosteric landscape of the Src kinase

Comprehensive allosteric mapping prioritizes all possible druggable surface pockets in the Src kinase for allosteric inhibition.

science.org

Another year, another US-engineered genocide. This time in Cuba.

Jason Hickel@jasonhickel.bsky.social · 6mo ago

To understand how monstrous the US blockade on Cuba is, think about the endgame. What are they trying to achieve? The goal is clearly to starve people to the point where they are too weak to resist an invasion, or so desperate they are willing to accept US control.

As the imperial boot of the US and Israel relentlessly pounds the face of the Palestinian people, the EU looks on in silence. Its inaction displays more than just stupidity and hypocrisy, the EU is complicit in genocide. www.theguardian.com/commentisfre...

By failing to sanction Israel, EU leaders are complicit in its crimes. They must act now | Josep Borrell

Europe’s silence has allowed the genocide of Palestinians to continue unchecked – undermining all it stands for, says Josep Borrell, a former EU high representative

theguardian.com

New preprint from the allostery team www.biorxiv.org/content/10.1...

Allosteric and Energetic Remodeling by Protein Domain Extensions

Many functions of proteins are performed by independently folding structural units called domains. The structures of domains are conserved during evolution but they are not identical. For example, the...

biorxiv.org

🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.

“Nothing is less real than realism. Details are confusing. It is only by selection, by elimination, by emphasis, that we get at the real meaning of things.” — Georgia O'Keeffe

On this day in 1954, the United States orchestrated a coup against Jacobo Árbenz, the progressive and democratically-elected leader of Guatemala, because he sought to restore land to small farmers and Indigenous communities that had been dispossessed by US fruit companies.

Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇 www.science.org/doi/10.1126/...

Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state

The aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state.

science.org

“Scientists often study the past as obsessively as historians because few other professions depend so acutely on it. Every experiment is a conversation with a prior experiment, every new theory a refutation of the old.” — Siddhartha Mukherjee, The Emperor of All Maladies

Any traders with inside information that Trump was going to walk back his tariffs — some of them, presumably, Trump family members and cronies — just made a fortune. It all feels like chaos until you look more closely at who is winning.

💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜

El 8-M de las científicas: miles de mujeres se vuelcan para despertar vocaciones en la niñas

Un movimiento imparable ha arrancado con fuerza: es el sigiloso 8-M de las científicas. Mujeres determinadas a enseñar a las chicas que pueden ser profesionales capaces

lavanguardia.com

At ALLOX @alloxbio.bsky.social in Barcelona we now have 3 computational positions available! 📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t 📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke 📌Computational Chemist 👉 tinyurl.com/5n6vpem3 Apply or repost to help us spread the word 🙏