Trilled that our work on reaction-based nanosensor of neurotransmitters is on the cover @jacs.acspublications.org ! Lock-and-key molecular recognition of dopamine inside lipid nanoreactor triggers a reaction leading to fluorescence turn-on of the nanosensor. @erc.europa.eu @cnrs.fr @unistra.fr
Andrey Klymchenko
@aklymchenko.bsky.social
CNRS senior researcher @unistra, @cnrs, @BrightSens Diagnostics, @AstraNICE. Working on fluorescent probes, organic nanoparticles, biomembranes, biosensing & bioimaging. #StandwithUkraine
We thank @cnrs.fr for highlighting our work on artificial receptors for detection of neurotransmitters that just came in @jacs.acspublications.org @erc.europa.eu @cnrs.fr @unistra.fr
#ResultatScientifique🔎| Des scientifiques montrent un nanosenseur capable de détecter les neurotransmetteurs avec précision grâce à un système combinant reconnaissance moléculaire et réaction chimique. ✍️ @aklymchenko.bsky.social 📕 @pubs.acs.org 🤝 @cnrs-alsace.bsky.social @unistra.fr
Happy to share our paper in @jacs.acspublications.org on a concept of reaction-based sensing of neurotransmitters driven by a molecular recognition in a lipid nanoreactor. Congrats and thanks to co-authors! @ERC_Research, @unistra.fr @cnrs.fr. pubs.acs.org/doi/10.1021/...
Molecular Recognition-Driven Reaction-Based Sensing of Catecholamines in a Lipid Nanoreactor
Reaction-based sensing is a rapidly expanding principle in the design of fluorescent probes. Although effective for sensing highly reactive species, it is less suitable for more complex small molecule...
pubs.acs.org
An immense honor to receive CNRS Silver medal 2026! I would like to thank my team @unistra.fr @cnrs.fr for their hard work and all our collaborators, Kyiv University for the solid education, and @cnrs.fr for providing me the opportunity to realize my dreams! Merci ! Thank you! Дякую!
Just out in Nanoscale: we found cooperative effects in DNA-functionalized polymeric nanoparticles, important for biosensing & diagnostics. Congrats & thanks to Paraskevi Gaki & startup BrightSens Diagnostics. @unistra.fr, @cnrs.fr, @bpifrance-officiel.bsky.social, #iLab pubs.rsc.org/en/content/a...
Our review on light-harvesting nanomaterials for energy transfer & biosensing is out in Adv Mater! We analyzed literature on optical materials mimicking nature – chlorophyll in plants. Thanks & congrats to co-authors: Deep Biswas & Pascal Didier! advanced.onlinelibrary.wiley.com/doi/full/10....
Ready to fly back with @aklymchenko.bsky.social to Paris! Thanks to @faseborg.bsky.social and the organisers for the fantastic event!
Great news: I received ERC Advanced grant #ERCAdG @erc.europa.eu CaptuRel! It aims at intelligent nanomaterials undergoing bioinspired cycle of capture and photorelease of bioactive molecules for sensing and controlling (bio)chemical gradients. Thanks to my Team, @cnrs.fr and @unistra.fr!
Today it is the MINT Day! A good occasion to share science and good moments together. We are really happy to welcome @aklymchenko.bsky.social to open this beautiful day! Thank you very much again for coming ☺️.
It was a great experience to participate in JCS2025 conference on supramolecular chemistry. Thanks @iwonanieren.bsky.social et al for the invitation and organization of this wonderful event!
Great plenary lecture of Andrey KLYMCHENKO @aklymchenko.bsky.social during the JCS2025 in Strasbourg @suprascf.bsky.social @unistra.fr
Bürgenstock Conference by @swisschemistry.bsky.social was a truly amazing meeting with brilliant lectures and leading researchers in chemistry: @klanglab.bsky.social, JL Mascarenas, R Buller, @olallalab.bsky.social, D Hilvert, etc. It was an honor to present our work. A big thank to the organizers!
New preprint: we introduce peptide-functionalized fluorescent polymeric nanoparticles with stealth properties due to rather short polysarcosine peptides for targeting proteins on cell surface. Congrats to co-authors! @cnrs.fr @unistra.fr @agencerecherche.bsky.social www.biorxiv.org/content/10.1...
We revisited our #MemBright toolbox and report anionic cyanine membrane probes with improved properties that enable in vivo imaging of neurons in mice brain. Congrats & thanks to co-authors! Just out Anal. Chem. @acs.org : pubs.acs.org/doi/10.1021/... @cnrs.fr @unistra.fr @lmumuenchen.bsky.social
New preprint alert: we found cooperative effects in DNA-functionalized polymeric nanoparticles, important for biosensing and diagnostics applications. Congrats and thanks to co-author Paraskevi Gaki. @unistra.fr, @cnrs.fr, @bpifrance-officiel.bsky.social, #BrightSens www.biorxiv.org/content/10.1...
Cooperative effects in DNA-functionalized polymeric nanoparticles
DNA-functionalized nanoparticles (NPs), called as spherical nucleic acids (SNA), attract strong attention due to their unique properties and numerous applications. In particular, DNA-functionalized dy...
biorxiv.org
The cover (frontispiece) for our recent article on artificial receptor for neurotransmitter dopamine is finally out in @angewandtechemie.bsky.social. Thanks to Jurga Valanciunaite for the artwork! Congratulations and thanks to the co-authors! @unistra.fr @cnrs.fr @agencerecherche.bsky.social
Packed room yesterday for a wonderful seminar from @aklymchenko.bsky.social from @cnrs.fr @unistra.fr #Fluorescence for #biomembranes #lipids #proteins cbm.cnrs-orleans.fr/wp-content/u...
cbm.cnrs-orleans.fr
A deep dive into magic of biomembrane organization thanks to brilliant talk by @leventallab.bsky.social at PSL Chemical Biology meeting in Paris, @institutcurie.bsky.social, @cnrs.fr
We thank @cnrs.fr for highlighting our work on the artificial receptor for dopamine, recently published in @angewandtechemie.bsky.social, in their news portal: www.insb.cnrs.fr/fr/cnrsinfo/... @cnrsbiologie.bsky.social @unistra.fr @cnrs-alsace.bsky.social
Vers une détection ciblée des neurotransmetteurs : un récepteur artificiel pour la dopamine
Les neurotransmetteurs ont un rôle clé dans le fonctionnement du cerveau et peuvent servir de biomarqueurs pour de nombreuses maladies neurologiques.
insb.cnrs.fr
New paper out 🎇 It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols: www.nature.com/articles/s41...
Measuring plasma membrane fluidity using confocal microscopy - Nature Protocols
Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...
nature.com
It is my first Bluesky post: I am thrilled that our work on MemGraft probes for “permanent” fluorescent labelling of plasma membranes is finally out in JACS Au! We established a concept of lipid-directed covalent labeling of plasma membranes. Open access article: pubs.acs.org/doi/10.1021/...