Tessera
Folgen

Erdinc Sezgin

@sciezgin.bsky.social

Scientist Immunology, Membranes, Lipids, Microscopes, Open Science

23 Posts823 Follower780 Folgt
Trends in Immunology@cp-trendsimmuno.bsky.social · 11mo ago

Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases #immunology

Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases

Autoimmune diseases arise from genetic and environmental factors that disrupt immune tolerance. Recent studies highlight the role of myeloid cell immunometabolism, particularly mitochondrial dysfunction, in driving autoimmunity. Mitochondria regulate energy homeostasis and cell fate; their impairment leads to defective immune cell differentiation, abnormal effector activity, and chronic inflammation. We propose that chronic metabolic stress reprograms myeloid cells, fueling a vicious cycle of cell death and immune activation. Over time, this may induce several states of maladaptation in myeloid cells. Viewing autoimmune disease through a metabolic lens offers new insight into disease mechanisms and highlights potential therapeutic opportunities targeting mitochondrial function to restore immune balance.

dlvr.it

Trends in Immunology@cp-trendsimmuno.bsky.social · 12mo ago

Mitochondria and lysosomes in T cell immunometabolism #immunology

Mitochondria and lysosomes in T cell immunometabolism

Metabolic reprogramming and signaling are key orchestrators of T cell immunity. Recent studies have illustrated important roles for intracellular organelles, especially mitochondria and lysosomes, in enforcing T cell metabolism and signaling in response to various extracellular cues. As such, mitochondrial and lysosomal function contributes to adaptive immunity by regulating T cell activation, differentiation, and functional adaptation. In this Review, we discuss how the interplay between organelle biology and metabolism instructs T cell-mediated immunity, with a particular focus on mitochondria and lysosomes. We also summarize how mitochondria and lysosomes, or their crosstalk with other organelles, orchestrate downstream signaling processes and functional reprogramming of T cells. We conclude with a discussion of the pathophysiological outcomes associated with dysregulation of these organelles.

dlvr.it

Jörg Enderlein@joergenderlein.bsky.social · 3mo ago

Excited to share our latest work in @ScienceAdvances! 🔬 We’ve developed "dynaMIET"—a new spectroscopy technique that finally allows us to simultaneously measure 3D membrane dynamics in live cells with nanometer precision. www.science.org/doi/10.1126/...

Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET)

dynaMIET enables simultaneous measurement of lateral diffusion and vertical membrane fluctuations in live cells.

science.org

Iván Hidalgo-Cenalmor@ivanhcenalmor.bsky.social · 3mo ago

Super excited to share a project I’ve worked on since my Master’s thesis, what a journey!🚵 Finally out as a Nature Methods Stage 1 Registered Report preprint doi.org/10.6084/m9.f... We benchmark deep learning-based single-image super-resolution methods for microscopy imaging. Interested? Check out 🧵

Accuracy versus Perception: a Benchmark of Deep Learning Models for Single-Image Super-Resolution in Microscopy

Virtual super-resolution deep learning methods provide a powerful solution to overcome the physical and temporal constraints of microscopy imaging. Yet, assessing and choosing an ideal methodological strategy complicates their use in life sciences and creates a lack of trust in these methods. Here we propose an objective comparison of nine popular single-image super-resolution (SISR) models in a collection of publicly available microscopy datasets, including cell components like microtubules, endoplasmic reticulum, and actin, using confocal microscopy, SEM, SIM, SMLM and STED microscopy modalities for fixed and live-cell microscopy data. The proposed models will be assessed quantitatively with a collection of metrics in microscopy and computer vision, and qualitatively by experts in the field. The proposed models will be made accessible through open, user-friendly, containerised notebooks. This systematic assessment of SISR approaches will provide a more comprehensive understanding of these methods' performance and contribute to standardising SISR methods in microscopy.

doi.org

Fran Bottanelli@franbottanelli.bsky.social · 4mo ago

Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...

The EMBO Journal@embojournal.org · 4mo ago

Revised role for actin-rich protrusions in T-cell activation: @franbottanelli.bsky.social @probablycarmen.bsky.social et al reframe them as sites of enhanced receptor activation by exclusion & clustering dynamics, rather than pre-enrichment of signaling components link.springer.com/article/10.1...

André Nadler@nadlerlab.bsky.social · 4mo ago

Now out in its final form in @jacs.acspublications.org: Reaction pathways & photoreaction yields of bifunctional lipid probes. The numbers that explain why we spend so much time optimizing protocols for cellular assays. 😉 pubs.acs.org/doi/10.1021/...

Bifunctional Lipid–Protein Cross-linking Efficiency and Reaction Products

Bifunctional diazirine lipids are versatile tools for mapping protein–lipid interactions and cellular localization by photo-cross-linking. Yet, the cross-linking efficiency of these probes has not bee...

pubs.acs.org

André Nadler@nadlerlab.bsky.social · 6mo ago

It's always important to carefully characterize the reactivity of your favorite tools to optimize applications. We teamed up with Carla Kirschbaum and Carol V. Robinson to map photolysis reaction pathways of bifunctional lipids www.biorxiv.org/content/10.6...

Patrick van der Wel@pcavanderwel.bsky.social · 4mo ago

Looks like a great @embo.org workshop coming in September: “Lipid Code to Life”, with a who’s who of lipid #biochemistry… (e.g. @dimovalab.bsky.social @holthuislab.bsky.social @sciezgin.bsky.social etc ) More info and registration: meetings.embo.org/event/26-lip... #lipids #biophysics

Lipid Code to Life

Modern lipid biology has evolved far beyond the traditional view of lipids as simple building blocks or energy substrates. Lipids are now recognised as dynamic regulators of biological structures and…

meetings.embo.org

Jeremy Baskin@jeremybaskin.bsky.social · 9mo ago

#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime

Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog

This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.

axial.acs.org

Rita Strack@ritastrack.bsky.social · 10mo ago

I hope this Nobel Prize gets people talking meaningfully about our amazing immune systems and the importance of basic research to human health (and funding basic research). I am also glad young women get to see that women can not only work at this level, but that those who do can get recognized.

Erdinc Sezgin@sciezgin.bsky.social · 10mo ago

Cell Physics community is missing Jochen Guck deeply.. He was a very kind and generous person, one of the most creative minds, and always ready to help everyone in the field.. He inspired many of us.. He will always be missed..

Bild
Gene Chong@chongg.bsky.social · 10mo ago

Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem www.nature.com/articles/s41...

Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology

Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

nature.com