F. nucleatum #LPS O-antigen engages #Siglec-7 through a previously unknown epitope, revealing how it may dampen immune responses in #CRC @robertamarchetti.bsky.social @molinarotony.bsky.social 👏 #glycotime #nmr #HostPathogen #Microbiome #Siglecs #microbiology #Glycans pubs.acs.org/doi/10.1021/...

Fusobacterium nucleatum Lipopolysaccharides O-Antigen Defines a Novel Siglec-7 Binding Epitope

Fusobacterium nucleatum (Fn) is a Gram-negative bacterium predominantly found in the human oral cavity, occasionally linked to systemic diseases, including colorectal cancer. Bacterial lipopolysacchar...

pubs.acs.org

#IQFPaper Structure of the Lipopolysaccharide from Paenalcaligenes hominis: A Chemical Perspective on Immune Recognition. Published in JACS Au Collaboration with @ciberisciii.bsky.social bit.ly/3I6JUn5

👇🏾👇🏾 "The power of sugar" International Award González-Ciamician 2024 conferences tour, Spain 2025 @molinarotony.bsky.social

👇 #Siglec-7 NMR assignment and binding studies with #gangliosides, impact of ligand flexibility #nmr #3D #glycan #glycotime #GD3 #structuralbiology #biophysics @robertamarchetti.bsky.social @molinarotony.bsky.social advanced.onlinelibrary.wiley.com/doi/10.1002/...

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec-7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A comb....

advanced.onlinelibrary.wiley.com

👇🏾Free #NMR School "The new frontiers of NMR: Advanced Applications", May 26th to 29th (Dept. of Chemical Sciences, University of Napoli Federico II) open to PhD students and Postdoc. To apply please email your CV to simone.potenti@unina.it by April 21st

👇👇 Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR #Siglec #NMR #glycotime, @robertamarchetti.bsky.social www.sciencedirect.com/science/arti...

Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR spectroscopy

Siglec-7, an immune checkpoint receptor, has emerged as a promising target for cancer immunotherapy due to its involvement in the regulation of immune…

sciencedirect.com

📢 #MSCA-DN AUREUS has 15 #PhDpositions open 📢 Apply now!! euraxess.ec.europa.eu/jobs/323721

Please repost if you think there should be a worldwide ban on harmful pesticides. 😡 ‼ Please sign, share & support (810 donators to 850+) to Save The Pollinators 👉 change.org/SaveTheBee 🆘

Christmas arrived early for me🎄🎁 just got a hard copy of the Nature Methods Nov 2024 issue with our GlycoShape article in it ❤️❤️ it smells sooo nice!!! 🤩🤣 doi.org/10.1038/s415...

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