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Roberta

@robertamarchetti.bsky.social

AssociateProfessor@OrganicChemistry@University of Naples Federico II. Protein-Glycoconjugate Interaction Studies by NMR. Coordinator of MSCA-DN #AUREUS. PI of ERC project #GLYCOSWITCH.

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Roberta@robertamarchetti.bsky.social · 4mo ago

Super proud to share with all of you the huge work we did to build the #GLYCAM Bacterial Carbohydrate Builder! @fnieto-fabregat.bsky.social @RobertWoods @OliverGrant

Ferran Nieto-Fabregat@fnieto-fabregat.bsky.social · 4mo ago

Bacterial glycans are a nightmare to model. Unusual sugars, missing parameters… I’ve been working on extending the GLYCAM builder to include them — together with @robertamarchetti.bsky.social, @olivercgrant.bsky.social and the group of Prof. Woods. Preprint👇 www.biorxiv.org/content/10.6...

Alba Silipo@albasilipo.bsky.social · last yr.

👇 #Siglec-7 NMR assignment and binding studies with #gangliosides, impact of ligand flexibility #nmr #3D #glycan #glycotime #GD3 #structuralbiology #biophysics @robertamarchetti.bsky.social @molinarotony.bsky.social advanced.onlinelibrary.wiley.com/doi/10.1002/...

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec-7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A comb....

advanced.onlinelibrary.wiley.com

Alba Silipo@albasilipo.bsky.social · last yr.

👇👇 Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR #Siglec #NMR #glycotime, @robertamarchetti.bsky.social www.sciencedirect.com/science/arti...

Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR spectroscopy

Siglec-7, an immune checkpoint receptor, has emerged as a promising target for cancer immunotherapy due to its involvement in the regulation of immune…

sciencedirect.com