Very happy to share the just published #correspondence in @thelancet.com (commenting on a recent #Seminar) revolving around the necessity to consider all the anti-#MRSA armamentarium, for #CAP and not only. #IDSky www.thelancet.com/journals/lan...
Alberto Enrico Maraolo
@albertoemaraolo.bsky.social
Assistant Professor of Infectious Diseases (University of Naples "Federico II", Italy). Passionate about antibiotic resistance, EBM, epidemiology and evidence synthesis in the ID field.
Just published: a review on the impact of #gender on #antibiotic use. In the era if #personalized medicine, taking into account gender is anothe piece of the #puzzle of antimicrobial management. www.tandfonline.com/doi/full/10....
Predictors of mortality of Enterococcus faecium bloodstream infections: results from a 5-year retrospective study at Padua University Hospital. One the largest cohort in the literature on the topic. - International Journal of Infectious Diseases www.ijidonline.com/article/S120...
Predictors of mortality of Enterococcus faecium bloodstream infections: results from a 5-year retrospective study at Padua University Hospital
The increasing prevalence of Enterococcus faecium (EF) bloodstream infections (BSIs) over the last years is concerning due to its high mortality rates and its intrinsic resistance to many antibiotics,...
ijidonline.com
Just published new #breakpoints by #EUCAST. #Bad news: values for #TMP_SMX have been significantly #lowered for key #pathogens. Bad news under an #antimicrobial_stewardhisp perspective since the combination is a cornerstone of #Oral_is_the_new_IV. @escmid.bsky.social #IDSky.
Nice brief overview on how to reconsider treatment targeting #PBPs, going beyond the simple fact that beta-lactams inhibit synthesis peptidoglycan. @sidpharm.bsky.social @contagionlive.bsky.social www.contagionlive.com/view/penicil...
Penicillin-Binding Proteins Reconsidered: A Clinician's Guide from Targets to Dynamic Cell-Wall Control | Contagion Live
PBPs are more than static β lactam targets. Host conditions rewire PBP activity and peptidoglycan architecture, shaping tolerance, resistance, and how we design salvage regimens.
contagionlive.com
Proud of the acceptance of a comment on a relevant paper on the combination between colistin and meropenem for invasive #CRAB infections.
Clinical Infectious Diseases@cidjournal.bsky.social · 11mo agoIt is time to go beyond the association between colistin and meropenem for invasive carbapenem-resistant Acinetobacter baumannii infections ✅ Just Accepted #IDSky 🔗 https://bit.ly/3Ksetom
Just published in @cidjournal.bsky.social a letter on the need to definitely move on in the treatment of #CRAB (#acinetobacter) infection, without further investing energies in assessing regimens (colistin plus meropenem) largely suboptimal. academic.oup.com/cid/article/...
It is time to go beyond the association between colistin and meropenem for invasive carbapenem-resistant Acinetobacter baumannii infections
Alberto Enrico Maraolo, Giancarlo Ceccarelli; It is time to go beyond the association between colistin and meropenem for invasive carbapenem-resistant Acin
academic.oup.com
Fantastic #decision_support_system to assess patients coming from abroad for #HCID (high consequences #infectious #diseases). Designed for #UnitedStates #physicians but useful even for specialists of other continents as #Europe. #IDXposts www.cambridge.org/core/journal...
Don’t know much about geography? Decision support for the evaluation of patients with suspected high consequence infectious diseases | Antimicrobial Stewardship & Healthcare Epidemiology | Cambrid...
Don’t know much about geography? Decision support for the evaluation of patients with suspected high consequence infectious diseases - Volume 5 Issue 1
cambridge.org
#SARSCoV2 has not disappeared. It has become even more insidious for immunosuppressed #patients, especially the ones with impaired humoral response, ensuing in a #chronic #infection. A letter in #NewMicrobesAndNewInfections takes sticks of the evidence. www.sciencedirect.com/science/arti...
COVID-19 in immunocompromised patients: proposed definition of a new entity with prolonged infection
sciencedirect.com
Potentially useful alternative to benzathine penicillin G for early #syphilis: oral cefixime (although with the downside of a 14-day course). Small but interesting #RCT. #IDSky academic.oup.com/jac/advance-...
Cefixime versus benzathine penicillin G for the treatment of early syphilis—a randomized, controlled open label trial
AbstractObjectives. Cefixime is a promising oral treatment alternative for early syphilis but only very limited efficacy data exist. We evaluated the effic
academic.oup.com
📺 New from FirstCallID: Non-Resolving Skin & Soft Tissue Infections When cellulitis isn’t improving, it’s easy to reach for broader antibiotics. But there’s a better way. Here is a clear, structured approach: 🧩 DDx 🚩 What to rule out 💊 Next steps 🔗 www.firstcallid.ca #FirstCallID #idsky #MedEd
FirstcallID - How to do an Infectious Diseases Consultation - Non-resolving Cellulitis
YouTube video by FirstcallID
youtu.be
Novel @idsainfo.bsky.social #guidelines on #urinary_tract_infections for the first time clearly address #complicated forms and revolve around 4 domains: 1) #definitions; 2) #empirical choices (crucial the presence of #sepsis); 3) #switch to oral #antibiotics; 4) #shorter therapies. #IDSky
IDSA@idsainfo.bsky.social · last yr.🚨 IDSA has released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs)! The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs. View guidelines: bit.ly/4lUjN1a
Finally out the #guidelines by @idsainfo.bsky.social on #urinary_tract_infections, introducing new definitions and providing important nuanced indications for #treatment. #IDSky #MedSky
IDSA@idsainfo.bsky.social · last yr.🚨 IDSA has released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs)! The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs. View guidelines: bit.ly/4lUjN1a
Just published in #Infection (#OpenAccess) likely the largest (retrospective multicenter) cohort so far comparing #Meropenem_Vaborbactam and #Ceftazidime_Avibactam for #KPC infections (#BSI and #pneumonia) in #ICU #patients. link.springer.com/article/10.1... #Italy #IDSky #PropensityScore
Head-to-head: meropenem/vaborbactam versus ceftazidime/avibactam in ICUs patients with KPC-producing K. pneumoniae infections– results from a retrospective multicentre study - Infection
Infection - Meropenem/vaborbactam (M/V) and ceftazidime/avibactam (C/A) are considered key agents in treating KPC-producing Klebsiella pneumoniae (Kp) infections. We compared these two drugs in...
link.springer.com
Very informative #Pk_Pd study from @Clinicalpharmacokinetics on #acyclovir dosing for #HSV/#VZV #encephalitis. Standard regimens (10 mg/kg TID) may be inadequate . Alternative strategies: increasing dosing (QID) or extending infusion durations. #IDSky link.springer.com/article/10.1...
Revisiting Acyclovir Dosing for Adult Viral Encephalitis Using a Full Bayesian LeiCNS PBPK Modeling Approach - Clinical Pharmacokinetics
Background and Objective Acyclovir is a primary treatment for central nervous system (CNS) infections caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV). However, patient outcomes r...
link.springer.com
The primary cause of the resurgence in #measles cases is failure to vaccinate, not failure of the #vaccine". Landmark #review on measles in @nejm.org, facing #pathogenesis, clinical #picture, #management and #prevention in the era of its #resurgence. #MedSky #IDSky www.nejm.org/doi/full/10....
Measles 2025 | NEJM
In this article on measles, the authors review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies.
nejm.org
Finally in volume (on Expert Review of Anti-Infective Therapy) the narrative review on the management of methicillin-resistant Staphylococcus aureus bloodstream infections. Below is the eprint link for free download. www.tandfonline.com/eprint/IE3MK...
Management of methicillin-resistant Staphylococcus aureus bloodstream infections: a comprehensive narrative review of available evidence focusing on current controversies and the challenges ahead
Bloodstream infections (BSIs) caused by Staphylococcus aureus are common worldwide, representing one of the most relevant issues in clinical infectious diseases practice. In particular, BSIs by met...
tandfonline.com
Very precious indications from Canadian Society of Internal Medicine for "high-value, low-carbon care" against the backdrop of climate change. Emphasis is put on oral antibiotics instead of intravenous whenever possible. link.springer.com/article/10.1...
#Vitamins are just "a small piece of the puzzle that determines infection susceptibility and severity" so general #supplementation is not a way to treat or prevent #infections. An exception is #Vitamin_A useful against #measles, especially in (malnourished) #children. #MedSky #IDSky
ASM@asm.org · last yr.Vitamins support immune function, but evidence on their role (and the role of vitamin supplements) in infection is mixed. How should we think about vitamins in the context of infectious disease? 💊 asm.org/articles/202...
Very informative review from @nature.com (Reviews #Microbiology) on how #vaccination in #pregnancy protects newborns, covering immunological aspects and providing practical recommendations. #IDsky #MedSky www.nature.com/articles/s41...
Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology
In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and t...
nature.com
Tecovirimat is available to treat mpox in the United States and Europe, but evidence for its efficacy and safety from randomized, controlled trials has been lacking. Findings from the PALM007 trial are summarized in a new Quick Take video. nej.md/4js3uHE #MedSky #IDSky
Placebo-Controlled Trial of Tecovirimat for Endemic Mpox | NEJM
Quick Take Video Summary from The New England Journal of Medicine — Placebo-Controlled Trial of Tecovirimat for Endemic Mpox
nej.md
Just published a multi-author #review born from a successful multidisciplinary approach (infectious diseases, microbiology, clinical pharmacology, intensive care) on #MRSA #BSI. Focus on #classification, #diagnosis and #therapy. Link to the paper: www.tandfonline.com/eprint/IE3MK... #IDsky #MedSky
#FUTURE_AI: an international consensus guideline for trustworthy and deployable #AI in #healthcare from @bmj.com in its "Research Methods & Reporting" section. A set of 30 best practices to cover the entire lifecycle of healthcare #AI. #MedSky #IDSky www.bmj.com/content/388/...
FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare
Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. This paper describes the FUTURE-AI f...
bmj.com
#IDSky #MedSky #PharmSky @idsainfo.bsky.social @cidjournal.bsky.social @ofidjournal.bsky.social @sidpharm.bsky.social 🚨 In this #BMJ article we update the clinical practice approach to adult fever of unknown origin #FUO! bmj.com/cgi/content/...
Fever of unknown origin
### What you need to know Fever of unknown origin (also known as fever of undetermined origin or pyrexia of unknown origin) is often a debilitating clinical syndrome. Patients with this syndrome pres...
bmj.com
Just published commentary in Critical_Care about the pitfalls underlying the "culture-negative" #sepsis definition, especially when dealing with #antibiotic appropriateness. Novel and fast #microbiology techniques are essential. #IDSky #IDsky ccforum.biomedcentral.com/articles/10....
The elusive concept of appropriate antibiotic for septic patients when a pathogen is not detected by standard culture methods - Critical Care
ccforum.biomedcentral.com
Worrying prediction according to mathematical modeling of the advent of a pandrug-resistant E. coli: #sepsis death in the #UnitedStates could increase 18- to 46-fold within 5 years. www.nature.com/articles/s43... #IDSky; #idsky
Predicting sepsis mortality into an era of pandrug-resistant E. coli through modeling - Communications Medicine
Koch et al. model scenarios of emergence of a single pan-resistant Escherichia coli strain in the United States. Findings suggest dire mortality outcomes and highlight the importance of measures to pr...
nature.com
Great results combining two landmark #trials (TB-CHAMP and VQUIN) in a #Bayesian framework to test efficacy of #levofloxacin to prevent #MDR_TB in #children. #MedSky #IDSky evidence.nejm.org/doi/full/10....
A Meta-Analysis of Levofloxacin for Contacts of Multidrug-Resistant Tuberculosis
Data from randomized trials evaluating the effectiveness of tuberculosis (TB) preventive treatment for contacts of multidrug-resistant (MDR)-TB are lacking. Two recently published randomized trials...
evidence.nejm.org
Notable article: #ELIMINATE phase 2 #RCT testing a cocktail of six bacteriophages in the setting of uncomplicated #urinary tract #infection. #Phage therapy is the future to counter #AMR, at least as complementary strategy to traditional antibiotics. #IDSky #MedSky www.thelancet.com/journals/lan...
Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial
A regimen consisting of 2 days of intraurethral LBP-EC01 and 3 days of concurrent intravenous LBP-EC01 (1 × 1010 PFU) and oral TMP–SMX twice a day was well tolerated, with consistent pharmacokinetic profiles in urine and blood. LBP-EC01 and TMP–SMX dosing resulted in a rapid and durable reduction of E coli, with corresponding elimination of clinical symptoms in evaluable patients. LBP-EC01 holds promise in providing an alternative therapy for uncomplicated UTIs, with further testing of the group A dosing regimen planned in the controlled, double-blind, second part of ELIMINATE.
thelancet.com
#Infections of the #eye are frequent (although of minor severity in most cases), but are often a neglected topic in the training path of an #ID physician. Usually well-written #review from @cidjournal.bsky.social takes stock of the subject. academic.oup.com/cid/article/...
State-of-the-Art Review: Ocular Infections
Collaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review
academic.oup.com
A great international effort to delve into many aspects of #prevention and #management of #infection, issued in the #AMR #Awareness week. Glad to have given a contribution about #Clostridioides_difficile. #IDSky infectionsinsurgery.org/global-digit...
Free global digital textbook
—- GLOBAL INFECTIONPREVENTION AND MANAGEMENT INHEALTHCARE ISBN: 978-88-943799-3-8FIRST PUBLISHED on 18 November 2024 — Volume 1 Antimicrobial resistance and One Health VOLUME 1download …
infectionsinsurgery.org