Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells

Nature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells

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Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection - Nature Communications

In this work, authors show that the loss of the carbapenem porin OprD in Pseudomonas aeruginosa reduces mucus entrapment and enhances airway epithelial barrier crossing, illustrating how antibiotic re...

nature.com

Explaining the stable coexistence of drug-resistant and -susceptible pathogens: the resistance acquisition purifying selection model

Drug resistance is a problem in many pathogens. While overall, levels of resistance have risen in recent decades, there are many examples where after …

sciencedirect.com

A DNA damage-activated kinase phosphorylates a transcriptional repressor to control bacterial immune pathway expression - The EMBO Journal

Bacteria encode numerous stress-response pathways that protect their hosts against both internal and external threats. A key question is how these pathways are regulated, especially anti-phage immune ...

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biorxiv.org

Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation - Nature Microbiology

Inactivation of chromosomal genes through plasmid-encoded IS elements is an extended mechanism of antimicrobial resistance evolution in bacteria.

nature.com

biorxiv.org

biorxiv.org

Plasmid mutation rates scale with copy number | PNAS

Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...

pnas.org

Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes - The EMBO Journal

Cellular and environmental stress triggers the rapid and global reprogramming of gene transcription by coordinated recruitment of a limited number of key inducible transcription factors to cis-regulat...

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Spx inhibits expression of the SwrA•DegU master flagellar activator in Bacillus subtilis | Journal of Bacteriology

Bacterial flagella are elaborate machines that are inserted through the bacterial cell envelope. The regulation of flagellar gene expression is organized in hierarchical tiers that largely correlate w...

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Antimicrobial resistance: a silent pandemic

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Non-conjugative plasmids limit their mobility to persist in nature

Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...

cell.com

Emergence of antiphage functions from random sequence libraries reveals mechanisms of gene birth | PNAS

De novo gene birth—the emergence of genes from nongenic sequences—drives biological innovation, yet its adaptive potential remains poorly understoo...

pnas.org

Phages communicate across species to shape microbial ecosystems

Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...

biorxiv.org

Trade-offs between phage resistance and conjugative ability shape the ecological and evolutionary response of a multidrug resistance plasmid to plasmid-dependent phage

Phage therapy is a promising alternative to antibiotics to treat multidrug resistant infections. Plasmid dependent phages (PDPs) are particularly attractive as therapeutics because they can both kill ...

biorxiv.org

Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance

Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...

doi.org

Creative experiences and brain clocks - Nature Communications

Creative experiences such as dance, music, drawing, and strategy video games might preserve brain health. The authors show that regular practice or short training in these activities is linked to brains that look younger and work more efficiently.

nature.com

Phages with a broad host range are common across ecosystems - Nature Microbiology

Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.

nature.com

Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS

Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to d...

pnas.org

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

rdcu.be

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation

Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...

biorxiv.org