Alvaro Sanchez

@asanchezlab.bsky.social

CSIC Professor and Principal Investigator of the Quantitative Biology group at IBFG in Salamanca. Previously at Yale EEB, CNB-CSIC. Our group works on building predictive models of biological teams. More information at www.sanchezlaboratory.weebly.com

Eye-opening work by @olimeacock.bsky.social (former postdoc, now PI in Sheffield). He presents an exact mapping from steady-state consumer-resource to generalized Lotka-Volterra models, revealing that cross-feeding can lead to competition for other limiting resources. Feedback pls!

Oliver Meacock@olimeacock.bsky.social · 2mo ago

New preprint from @saramitri.bsky.social and me: tinyurl.com/3dsjnm4d The headline result - we derive a general way to connect mechanistic ecosystem models to the gLV equation. This reveals that strengthening cooperative mechanisms can make effective gLV interactions increasingly competitive. Weird!

Delighted to see this out in its final form! doi.org/10.1093/isme... We established a discussion group focussed on the history of community ecology and how it informs our understanding of microbiota. This review distils those discussions to provide a guide for microbiologists entering the field

A microbiologist’s field guide to community ecology

Abstract. Many microbiological outcomes are shaped by the determinants of community composition, including the factors that allow pathogens to invade healt

doi.org

The version of record of our revised preprint is finally out today. In it, we introduce a fast and reliable methdology for the full factorial design of microbial communities, i.e. constructing every monoculture, pair, trio, four-member,... n-member co-culture of N strains. doi.org/10.7554/eLif...

Full factorial construction of synthetic microbial communities

A rapid, inexpensive, and easy to implement experimental protocol enables the construction of combinatorially complete sets of microbial consortia.

doi.org

"Tell me who your friends are, and I’ll tell you who you are." It turns out, microbes follow the same rule! Very proud to share our lab's new paper in @natmicrobiol.nature.com showing that bacteria don't just respond to their environment, they respond to each other. www.nature.com/articles/s41...

Community context reshapes microbial proteomes and reduces functional overlap - Nature Microbiology

Biotic interactions modulate protein abundance, reducing functional redundancy and increasing productivity in complex bacterial communities.

nature.com

It looks like there will be an open postdoc position in my lab soon. I'll be looking for someone with substantial wet-lab experience in microbiology / microbial ecology / evolution / physiology. If everything goes well, an ad will be coming. But if you know someone, ask them to reach out already.

This paper started as an idea @albertomarina.bsky.social had many years ago… which of course means he was right all along 😄. Some of us just needed a few years (and a lot of experiments) to catch up. Grateful (and slightly humbled) to be part of this. Thanks Alberto! www.cell.com/cell/fulltex...

Phages communicate across species to shape microbial ecosystems

Gallego-del-Sol et al. show that arbitrium-coding phages can sense non-cognate peptide signals from other phages to regulate lysis-lysogeny decisions. This crosstalk affects lysis-lysogeny outcomes of...

cell.com

We are pleased to share our last article rdcu.be/fabhM. It offers the most comprehensive analysis so far of Ab+non-Ab resistance genes in human gut microbiome, using an Indigenous population (low industrialization, chronic Hg exposure from gold mining) 6/6👇

The antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the “robust-yet-fragile” architecture ...

rdcu.be

Excited to share our latest work! 📝 We measured the fitness effect of 136 AMR genes and found that many are neutral or even beneficial without selection. 🤯🧬 Oxygen availability can flip their fitness and our stochastic model indicates that oxygen fluctuations help maintain them. Learn more 👇🏼

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 5mo ago

Fitness effects of antimicrobial resistance genes in changing environments https://www.biorxiv.org/content/10.64898/2026.03.06.710025v1