Generation of membrane-permeable cyclic peptides inhibiting protein–protein interaction - Nature Chemical Biology

Membrane-permeable cyclic peptides offer access to difficult intracellular targets but discovery remains challenging. Here the authors show that cell-active cyclic peptides can be identified by screen...

nature.com

Scientist/Senior Scientist for Peptide Research

Check out this open position at Novo Nordisk. Starting a career with us is your opportunity to improve the lives of millions of people.

novonordisk.com

Sr. Director for Peptide Innovation

Check out this open position at Novo Nordisk. Starting a career with us is your opportunity to improve the lives of millions of people.

novonordisk.com

Bulk Measurement of Membrane Permeability for Random Cyclic Peptides in Living Cells to Guide Drug Development

Some cyclic peptides can cross membranes, which is highly attractive for drug development, but it remains difficult to accurately predict membrane permeability or to test it experimentally for large ...

onlinelibrary.wiley.com

Senior Scientist I - Peptide and Macrocycle Chemistry

Senior Scientist I - Peptide and Macrocycle Chemistry

careers.novonordisk.com

Post-Doctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge

Post-Doctoral Research Associate (Fixed Term) in the Yusuf Hamied Department of Chemistry at the University of Cambridge.

jobs.cam.ac.uk

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11

Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

pubs.acs.org

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11

Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

pubs.acs.org

UZH: PhD Student Position in Peptide Chemistry

A PhD Student position is available in the group of Prof. Dr. Karl Gademann, located in the Department of Chemistry at the University of Zurich (Switzerland). Our group combines the synthesis of natur...

jobs.uzh.ch

Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11

Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

chemrxiv.org

Photochemically-enabled, post-translational production of C-terminal amides - Nature Communications

C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and manufacturing-scale. Here, the authors report ...

nature.com

De novo development of small cyclic peptides that are orally bioavailable - Nature Chemical Biology

Cyclic peptides show promise for modulating difficult disease targets; however, they often cannot be administered orally. The authors developed a method to synthesize and screen large libraries of sma...

nature.com