Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @aysuo.bsky.social, @paturley.bsky.social, @alextisyoung.bsky.social, and @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025... Thread below for details.

Dissecting the Predictive Accuracy of Polygenic Indexes for Behavioral Phenotypes Across Genetic Ancestries

Polygenic indexes (PGIs) trained on samples of European genetic ancestries often lose substantial predictive power when applied to non-European ancestries. While this portability problem is well recog...

doi.org

bioRxivpreprint@biorxivpreprint.bsky.social · 11mo ago

Dissecting the Predictive Accuracy of Polygenic Indexes for Behavioral Phenotypes Across Genetic Ancestries https://www.biorxiv.org/content/10.1101/2025.09.11.675704v1

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1

New review on the genetics of schizophrenia, depression, and bipolar disorder. www.nature.com/articles/s41...

Genomics of schizophrenia, bipolar disorder and major depressive disorder

Nature Reviews Genetics - Genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, revealing genetic architectures and risk mechanisms...

nature.com

UK Genome Science meeting - Newcastle. 9th - 11th July 2025. Great speakers. Great community. Early bird registration-16th May Abstract submission-23rd May Registration close-26th June If you want that sweet sweet early bird deal - get going quick! www.genomescience.org.uk

Genome Science UK 2025

Newcastle University

genomescience.org.uk

Some really interesting contrasts in our new "assumption-free heritability" preprint: papers.ssrn.com/sol3/papers....

Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%! Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1 @eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social

Rafael Ahlskog@rafaelahlskog.bsky.social · last yr.

Some really interesting contrasts in our new "assumption-free heritability" preprint: papers.ssrn.com/sol3/papers....

Great work on estimating heritability using sibling relatedness variation (estimated using my software package snipar). Surprisingly low h2 for education and high h2 for IQ (with large SE). Give it a read!

Uku Vainik@ukuvainik.bsky.social · last yr.

Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%! Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1 @eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

A great opportunity to work with @alextisyoung.bsky.social if you're interested in methods development!

Alex Strudwick Young@alextisyoung.bsky.social · last yr.

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data. Check it out 👇. It is very cool! geneticscores.org It is linked with the @pgscatalog.bsky.social This was supported by INTERVENE

Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

Our UU colleague Wes Sundquist won the 2024 Breakthrough of the year! His long-term research into the structure and function of HIV’s capsid protein has led to the development lenacapavir, a game-changing new treatment that is extremely effective at preventing HIV. www.science.org/content/arti...

Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention

A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

science.org

www.medrxiv.org/content/10.1...

Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals

Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...

medrxiv.org

After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off. But here's the genome now! www.biorxiv.org/content/10.1...

CGC1, a new reference genome for Caenorhabditis elegans

The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...

biorxiv.org

Tumour mutational burden: clinical utility, challenges and emerging improvements

Tumour mutational burden: clinical utility, challenges and emerging improvements - Nature Reviews Clinical Oncology

Tumour mutational burden (TMB), reflecting the number of mutations present in the DNA of a tumour, is a biologically appealing biomarker of a response to immune-checkpoint inhibitors (ICIs). Nonethele...

nature.com

Great to see this paper out in Nature today! One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.

Emilie Wigdor@emiliewigdor.bsky.social · 2y ago

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

a couple of cartoon characters standing next to each other with one wearing a purple earring

Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring

media.tenor.com

Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals #icanhazpdf? www.nature.com/articles/s41...

Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals - Nature Human Behaviour

In 394,005 UK individuals with exome sequencing data, Wu et al. find 56 neuroticism-associated genes (18 novel) and quantify the heritability explained by rare coding variants, highlighting the associ...

nature.com

Check out this University of Colorado newsletter that describes work being done by IBG faculty member @dangustavson.bsky.social using the VETSA twin dataset to examine genetic and environmental influences on cognitive decline. www.colorado.edu/asmagazine/2...

Detecting cognitive decline before its symptoms start

In his research on the brain, Daniel Gustavson looks for clues about when cognitive decline beginsAccording to Daniel Gustavson, assistant research professor in

colorado.edu

I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience. Details here: www.findaphd.com/phds/project...

New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath on FindAPhD.com

PhD Project - New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath, listed on FindAPhD.com

findaphd.com

Review: Inference and applications of ancestral recombination graphs https://www.nature.com/articles/s41576-024-00772-4 (read free: https://rdcu.be/dVyQH) 🧬🖥️

Perhaps this has not been said yet here: Include figures and legends in the manuscript along with the text. Otherwise, I may not read your preprint. If I have to review it without them, I’ll be starting off on the wrong foot. I love science, but don’t make me angry.

🚨IBG is hiring for a Tenure Track Assistant Professor! Candidates should have a background in neurogenetics, high-content genomics, experience with iPSC-derived neurons and glia and neural organoids, and expertise in neurodegeneration. More details here: jobs.colorado.edu/jobs/JobDeta...

The final program for the conference is now up: events.columbia.edu/cal/event/ev...

Molly Przeworski@mollyprz.bsky.social · 2y ago

Stream or attend a conference on Frontiers in Human Genetics at Columbia University (Oct 10 & 11), by registering here: events.columbia.edu/cal/event/ev...

One more week to apply! We are recruiting a postdoc to work on the evolutionary genetics of admixture in maize and teosinte.

A log Galton board can give an intuition about the drivers of the skewed shape of income distributions. Every success can offer people subsequent opportunities to gain much more while early failures shrink future opportunities Excellent animation by @babeheim.bsky.social

The exome sequencing plus imputation pipeline developed by Regeneron is impressive in its efficiency for discovering genetic associations that are potential drug targets. But having whole genomes for the entire UKB is cool and will prove more useful in the long run www.nature.com/articles/s41...

Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank - Nature Genetics

Comparison of association signals in UK Biobank using different strategies for assessing genetic variation shows that whole-exome sequencing combined with array genotyping and imputation offers simila...

nature.com

I made some substantial updates to this blog post with the advice from Isabella Ghement. #rstats #stats

Matthew B. Jané@matthewbjane.bsky.social · 2y ago

Here is a blog post on using Generalized Additive Models (GAMs) for meta-analysis or, more specifically, meta-regression in {brms}: matthewbjane.com/blog-posts/b...