If you're looking to do a postdoc or a PhD, check out our exemplar publications and feel free to get in touch: www.inouyelab.org/home/publica...

Just got our @genomeresearch.bsky.social article by Margarita Geleta. 📬 I love hard copies...still here's a link genome.cshlp.org/content/36/2... Rita's article was a tour de force of genomic uses for the autoencoder architecture: compression, dim reduction, ancestry, synthetic genomes.

Excited to share our work on "Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions" @genomestake.bsky.social @natgenet.nature.com - www.nature.com/articles/s41...

We’re looking for a Statistical Geneticist to join our team at @humantechnopole.bsky.social. The role offers the opportunity to work across a wide range of projects, supporting research groups throughout Human Technopole while developing and implementing new statistical methods tinyurl.com/44uyt8u2

Come and join our dream team! We’re recruiting a PhD candidate with a strong background in statistics, machine learning and (human) genetics to work at the interface of biological sequence foundational models and scores polygenic score methods.

New preprint: genetic variation and healthcare spending Across ~1.43M people, we identify hundreds of cost-associated variants, strong HLA signals, and higher costs among carriers of rare pathogenic variants in genes including BRCA1/2 and APC. www.medrxiv.org/content/10.6...

Quantifying the contribution of genetic variation to healthcare expenditure across diverse healthcare systems

Healthcare systems must balance rising costs with the delivery of effective care, yet the factors underlying large inter-individual differences in healthcare expenditure remain incompletely understood...

medrxiv.org

Scaling genetic clustering (ADMIXTURE/STRUCTURE-style unsupervised clustering) is now easy. Out in Bioinformatics, our ADAMIXTURE method clusters all of UK Biobank (500k genomes) in just over a hour with likelihoods as good as ADMIXTURE, which would take weeks. doi.org/10.1093/bioi...

ADAMIXTURE: adaptive first-order optimization for biobank-scale genetic clustering

AbstractMotivation. Estimating genetic clusters from sequencing data is a fundamental task in population and medical genetics, enabling demographic inferen

doi.org

Excited to share 2 important milestones in my academic journey- Our work on “Pervasive interactions between exposures & polygenic risk can inform more effective clinical & behavioral interventions,” showing PGSxC interactions & their utility, is out in #NatureGenetics @genomestake.bsky.social

A meta-science thought. There are >11k papers on PubMed on polygenic scores. It's a huge waste of resources. It's mostly one question that matters. When reporting to people either their real PRS or a random PRS, do people in the real PRS group have better health outcomes years later?

Pre-print on the impacts of the second plague pandemic and concurrent historical processes in 529 human genomes (mean 8.8x) from @ucph.bsky.social, Amgen/deCODE genetics, and many collaborators. We'd be grateful for any feedback before publication, so please share!

bioRxiv Genomics@biorxiv-genomic.bsky.social · last mo.

Genomic impact of the second plague pandemic on three human populations https://www.biorxiv.org/content/10.64898/2026.06.29.730585v1

The UK Biobank being inaccessible for half a year is annoying but also a great natural experiment. I'm wondering if in 3-4 years scientists could see the impact. Could teach us a lot about the scientific process and the value of biobanks.

All talks are now available including mine: www.youtube.com/watch?v=zZmF... Luckily the video became online on the same day as the paper I talked about at the end of my talk "confidentially" 😅

Du Paléolithique moyen au Paléolithique supérieur... (4) - Jean-Jacques Hublin (2025-2026)

YouTube video by Sciences de la vie - Collège de France

youtube.com

Collège de France@college-de-france.fr · last mo.

#Science #Paléoanthropologie 💀 « Sapiens remplace Néandertal » 🖥️ Les vidéos du colloque organisé par le  Pr Jean-Jacques Hublin, titulaire de la chaire Paléoanthropologie, sont disponibles. 👉 https://tinyurl.com/4pkf3nty

Family history has been recognised as a risk factor for psychiatric disorders since the late 18th century. In this new preprint, we leverage family history of psych and neurodev diagnoses to estimate family-genetic risk scores (PA-FGRSs) in the Norwegian population🧵 doi.org/10.31234/osf...

From Nuisance to Signal: Leveraging Close Relatives in Biobank-Scale Demographic Inference https://www.biorxiv.org/content/10.64898/2026.06.15.729614v1

Accepted a review request two weeks ago for a Springer journal. Reminder emails on days 6, 9, 13, and again on day 13. Spent a day reading and preparing the review. On day 14, just before sending out the review, received a message that my review is no longer needed. Why do we agree to this???

Nice paper studying the extent to which an individual with known traits can be linked to their genome. Authors argue that the practical risk is minimal, except in specific settings where the number of candidate genomes is very small.

bioRxiv Genetics@biorxiv-genetic.bsky.social · 2mo ago

Evaluating anonymized genome re-identification using polygenic predictions and its implications for data privacy https://www.biorxiv.org/content/10.64898/2026.06.10.731306v1

Our preprint on the genetic regulation of mtDNA gene expression in collaboration with @shwetaramdas.bsky.social and @rajivmccoy.bsky.social .

Great to see @annikafreudiger.bsky.social paper published! 🎉 We analyzed how genetic markers are used to estimate relatedness in wild animals - a big field with 2861 relevant publications. 📈🧬 Even in 2026 mainly STRs are used - and we argue for low coverage WGS data and a simple aDNA estimator.

Molecular Ecology@molecology.bsky.social · 2mo ago

New in MEC! @annikafreudiger.bsky.social et al. assess genetic relatedness on rhesus macaques and find that low-coverage whole-genome sequencing offers an accurate, cost-effective alternative to widely used methods. @wileyecology.bsky.social 📷 Caribbean Primate Research Center 🔗 buff.ly/pPOONsu 1/3

Happy to present our perspective on how to think about group-differences in genetic risk. With @nicole-kleman.bsky.social , Meng Lin, and Chris Gignoux.

Tread lightly interpreting group differences in genetic risk

Observed differences in mean phenotypic values across human groups have attracted renewed interest with the rise of large-scale genomic studies and polygenic risk prediction. However, the genetic basi...

arxiv.org

Just published our new paper: “The reliability of inferred archaic segments” 🎉🧬💀 www.pivotscipub.com/hpgg/6/2/000... We systematically compare several published methods and our new method "cp-archaic" using simulations and 1000 Genomes data

Very excited about this preprint that we just posted. It introduces the Genomic-Relatedness Matched Association (GRMA) study. It’s an extension to family-based GWAS that uses extended relatives beyond only siblings in diverse-ancestry data with very little bias. (Link below.)

I'm thrilled to share our new paper out today in @currentbiology.bsky.social! I teamed up with researchers at @harvardmed.bsky.social and the Smithsonian to study another historical American population using the 23andMe genetic database. 🧵 [1/9] Read it here: www.cell.com/current-biol...

Nice review paper on the genetics of founder populations. Covers historical research, recent findings, and methods for studying founder populations in large biobanks. By @christacaggiano.bsky.social, @roohy.bsky.social, @eimearekenny.bsky.social www.annualreviews.org/content/jour...

Revisiting Founder Populations in an Age of Global Biobanks

Founder populations have played a pivotal role in human genetics, enabling the discovery of causal variants for disease and providing insight into population history and dynamics. The rapid expansion ...

annualreviews.org

Population geneticists! Come work at 23andMe! New role just posted. 23andme.wd5.myworkdayjobs.com/23/job/Palo-...

Just sharing our most recent preprint. Would welcome feedback. Sex differences in the genetic basis of human recombination within 190,000 parent-child pairs. www.biorxiv.org/content/10.6...

Finally an official publication of Pileupcaller. Please cite. Thanks to @joss-openjournals.bsky.social for the review process and publishing!

Journal of Open Source Software@joss-openjournals.bsky.social · 3mo ago

Just published in JOSS: 'PileupCaller: A command-line tool to sample genotypes from low-coverage sequencing data of ancient DNA' https://doi.org/10.21105/joss.08634

1/ New paper out in Nature Communications! We studied the salivary amylase gene, AMY1, in Indigenous Andean populations and found evidence that high AMY1 copy number rapidly increased in frequency, likely through recent positive selection. doi.org/10.1038/s414...

Rapid adaptive increase of amylase gene copy number in Indigenous Andeans - Nature Communications

The salivary amylase gene exhibits copy-number variation linked to dietary shifts. Here, the authors describe an adaptive expansion of the amylase gene in Indigenous Andean populations coinciding with...

doi.org

Highly efficient genotype compression leveraging genealogical relatedness https://www.biorxiv.org/content/10.64898/2026.04.29.721594v1

New preprint! Introducing DIMPLE-GWAS - a new dimensionality-reduction method to capture latent endophenotypes. Applied to pleiotropic brain imaging data in UK Biobank, we developed a new brain atlas composed of 25 core "clusters" Details below and at my #SOBP talk Sat 3pm

Nice piece on today’s eugenics for the rich, polygenic risk scores in embryos. This article is unusually strong in its thoughtful discussion of the underlying science, with contributions by @shaicarmi.bsky.social and others. nymag.com/intelligence...

Can You Really Choose Your ‘Best Baby’?

Anxious parents are buying $50,000 genetic tests that might not be worth much of anything.

nymag.com