Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience

Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...

nature.com

Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms

Sensory neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are critical for transmitting somatosensory information, including pain, to the central nervous system. In these neurons, a...

jneurosci.org

A Podcast by Neuroverse: Tools for Looking into the Brain -…

Explore what pain really is and why it’s so complex. In this podcast, Prof. Sascha Alles unpacks how chronic pain develops and how the brain processes it.

scientifica.uk.com

Potential role for immune cell signatures as predictors of acute and chronic pain in adolescents post major musculoskeletal surgery - PubMed

Our findings suggest that immune cell signatures are potentially useful as biomarkers, prognostic indicators, and guides for personalized surgical recovery in youth.

pubmed.ncbi.nlm.nih.gov

Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain

Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an A…

sciencedirect.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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A combined activity of peripheral nociceptive and... : PAIN

eptors. Using electrical and optogenetic approaches, we selectively activated different fiber subtypes without causing neuronal injury. Our findings demonstrate that only simultaneous activation of bo...

journals.lww.com

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

nature.com

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications

Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

nature.com

EXPRESS: Gabapentin's effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles - Pain Research Forum

Source: Molecular pain Authors: Jenna B Demeter, Nesia A Zurek, Maddy R Koch, Aleyah E Goins, Cristian O Holguin, Mark W Shilling, Michael S Davis, Reza Ehsanian, Sascha Ra Alles, June Bryan de la Peñ...

painresearchforum.org

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons - Communications Biology

Single cell RNA-sequencing, spatial transcriptomics and chromatin analyses of sensory neurons provide insights into cell type organization of the dorsal root ganglion and the enhancer-driven co-regula...

nature.com

A robust expression system reveals distinct gating mechanisms and calmodulin regulation of NaV1.9 channels

An expression system enables detailed study of NaV1.9 channel gating and its regulation by calmodulin.

science.org

Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine - PubMed

Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating ac...

pubmed.ncbi.nlm.nih.gov

Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo

Voltage-gated CaV2.2 channels underlie the N-type current, and they regulate calcium entry at many presynaptic nerve endings to control transmitter release. A role for CaV2.2 channels has been well-es...

biorxiv.org

Human assembloid model of the ascending neural sensory pathway - Nature

A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to s...

nature.com

Frontiers | Pharmacological Perspectives into Transient Receptor Potential Channels

Transient Receptor Potential (TRP) channels constitute a diverse family of ion channels found in various cell types and tissues throughout the body. These ch...

frontiersin.org

Cholecystokinin in nociception and pain

The neuropeptide, cholecystokinin (CCK), and its receptors, CCK1R and CCK2R, are involved in nociception and pain. CCK1R and CCK2R are Gq-coupled GPCR…

sciencedirect.com