When You Don’t Feel Pain: Why the Ability to Hurt Actually Saves Your Life Not feeling pain might sound like a dream—especially if you live with chronic pain—but pain is one of the body’s most important protective systems. People with congenital insensitivity to pain often break bones, burn…

Epic Sunset in Playa Grande, Costa Rica. #travel #travelphotos #puravida #sunset #paradise #vacation #costarica

When Your Nerves Get Trigger-Happy: Understanding Peripheral Sensitization Lingering pain, despite healing, may stem from peripheral sensitization, where nerves become overly sensitive. This can lead to pain from stimuli that typically wouldn't hurt, known as allodynia and hyperalgesia. Strategies…

When Your Nerves Get Trigger-Happy: Understanding Peripheral Sensitization

Lingering pain, despite healing, may stem from peripheral sensitization, where nerves become overly sensitive. This can lead to pain from stimuli that typically wouldn't hurt, known as allodynia and hyperalgesia. Strategies for relief include graded movement, stress reduction, adequate sleep, addressing fear, and certain medications, which can help recalibrate the nervous system.

docnessmonster.com

3 Myths About Chronic Pain and the Power of Movement Living with chronic pain can feel like walking through a maze of misinformation. Let’s clear the path by busting three common myths and showing how movement can help you reclaim your life. Myth #1: “If it hurts, you should stop moving.” Reality:…

3 Myths About Chronic Pain and the Power of Movement

Living with chronic pain can feel like walking through a maze of misinformation. Let’s clear the path by busting three common myths and showing how movement can help you reclaim your life. Myth #1: “If it hurts, you should stop moving.” Reality: Mild discomfort ≠ harm In many chronic pain conditions, peripheral sensitization occurs—your peripheral nerves become overly reactive. This means things that shouldn’t hurt (like a light breeze) can feel painful, and mildly painful things can feel severe.

docnessmonster.com

“It's supernatural Extraterrestrial I know a bar out in Mars Where they drivin' spaceships instead of cars” #KatyPerry #halloween

@ninaluong.bsky.social is really upping her costume game this year. And she can still work in it!

We lost an icon today! Activist, scientist, and a difficult woman! #JaneGoodall

Our final contribution to this collaboration is now online. We obtained electrophysiological recordings of DRG/TG neurons and Fos+ neurons of spinal dorsal horn & vlPAG in 2 models of neuropathic pain to study the actions of a humanized P2X4R scFv #PainResearch www.sciencedirect.com/science/arti...

Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain

Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an A…

sciencedirect.com

⚡We are finally electrocuting DRG neurons in the @alleslab.bsky.social since moving to @cincychildrens.bsky.social! #PainResearch #ephys #NeuroSkyence

🧪Biomarkers in a clinical setting for Alzheimer’s! Scientific work in identifying biomarkers for all sorts of health conditions leads to faster diagnosis, informs treatment, and improves health!

The Dementia League@dementialeague.bsky.social · 12mo ago

🧠Guideline Alert for use of Dementia Blood Markers Alzheimer's Association emphasizes use of blood-based biomarkers (BBMs) with ≥90% sensitivity as triage testing and can serve as substitute tests for Amyloid PET imaging or CSF biomarker testing in Alzheimer's diagnosis. 1/2

🧪Word of the Week: Biomarker A measurable signal in the body, like a molecule in the blood, that tells us something about health, disease, or response to treatment. For pain, biomarkers could help make the invisible visible, giving us ways to track or predict pain. #SciComm #PainResearch

A blood test for pain? New work in Nature identifies circulating biomarkers that distinguish chronic pain states—offering a path toward objective, biologically grounded diagnostics. #PainResearch #Neuroskyence #Biomarkers #ScienceWatch #SciComm #ScienceInTranslation #ChronicPain

Next-generation precision medicine for pain - Molecular Psychiatry

Molecular Psychiatry - Next-generation precision medicine for pain

nature.com

Doing my best to get better at this! You will see more and more from me as I try to communicate what we do, how we do it, and what it all means! Hoping to reach not just the science folks here on BS but non-scientists as well!

Nicole Rust@nicolecrust.bsky.social · last yr.

Some scientists haven't yet internalized the "why" behind science writing for the public - not just as a service, but for themselves. (I didn't always get it). In this piece for @natrevneuro.nature.com, I draw on the neuroscience of curiosity & decision making to unpack its value. rdcu.be/eCGr7

1/ Word of the Week: Dorsal Root Ganglia (DRG) Clusters of nerve cell bodies (soma) near the spinal cord that relay sensory signals - including pain - from the body to the brain. Curious what they look like in real human tissue? See thread below #NeuroSkyence #PainResearch #ChronicPain #SciComm

One of our final papers from this collaborative effort involving collaborators at UNM, Mayo Clinic, & McGill. Here we validate a humanized scFv targeting hP2XR. Kudos to first-author @docnessmonster.bsky.social & former lab member Mark S. for making this happen! journals.sagepub.com/doi/10.1177/...

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🧠From Lab To Life Why do peripheral nerves suffer axonal loss in diabetes? A study led by @dianatavf.bsky.social from the @tedpricethepainguy.bsky.social lab showed how inflammation leads to neural fibrosis in diabetic peripheral neuropathy! #PainResearch #Neuroskyence #FromLabToLife 1/

📸 Big day in the lab! Our new electrophysiology rig is officially up and running — huge thanks to everyone who helped make this happen. Excited for the science ahead! 🧠⚡️ @alleslab.bsky.social @cincychildrens.bsky.social #PainResearch

This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research. By @claudia-lopez.bsky.social www.thetransmitter.org/community/ha...

Harvard University lays off fly database team

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

thetransmitter.org

🔬 Very cool work from @aubinmoutal.bsky.social, @khannalabuf.bsky.social, and team! These studies reveal how auto-antibodies—like those seen in autoimmune diseases—can directly target sensory neurons in the dorsal root ganglia, driving painful neuropathies. #PainResearch

Aubin Moutal@aubinmoutal.bsky.social · last yr.

I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41... This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes. #PainResearch

Gabapentin is widely prescribed for nerve pain, but it doesn’t work the same for everyone. We studied actual human sensory neurons from donors and found that some responded strongly - and others hardly at all. #fromlabtolife #neuroskyence #PainResearch 1/4

🧠 From Lab to Life New research shows Tylenol may quiet pain at its source by blocking Nav1.7 and Nav1.8, sodium channels critical for pain signaling. That’s a big deal for the most common active ingredient in U.S. meds. 1/4 #FromLabToLife #PainResearch #NeuroSkyence

Now online - our studies of mouse and human sensory neurons in the context of visceral pain! #PainResearch journals.sagepub.com/doi/10.1177/...

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Our collaborative study with the de la Peña lab is now online! Here we analyzed ephys & transcriptomic actions of gabapentin on hDRG neurons. Kudos to co-first authors Jenna & @docnessmonster.bsky.social. Special thks to our donors & their families #PainResearch journals.sagepub.com/doi/10.1177/...

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

In case anyone tells you “you aren’t worth anything,” your genetic data is worth $17 million. #23andMe #Regeneron #DNA #IAmNotForSale

Regeneron to buy bankrupt DNA testing firm 23andMe for $256 million | CNN Business

Drugmaker Regeneron Pharmaceuticals will buy genetic testing firm 23andMe for $256 million through a bankruptcy auction, the companies said Monday.

cnn.com

Cool history of #LLMs told by the experts! #ai

When ChatGPT Broke an Entire Field: An Oral History | Quanta Magazine

Researchers in “natural language processing” tried to tame human language. Then came the transformer.

quantamagazine.org

We are officially in Cincy! #neuroskyence #painresearch

Alles Lab@alleslab.bsky.social · last yr.

First day! @cincychildrens.bsky.social #PainResearch

We made it to St. Louis!!! #DogIsMyCopilot #STL #GatewayArch

In Oklahoma City we stayed at the Fordson Hotel. It used to be a Model T Assembly plant! Gorgeous hotel in a nice neighborhood west of downtown! Pierre and I finally felt like we could relax and breathe for the first time in days! #DogIsMyCopilot #Ford #ModelT #OKC #MovingOnUp

Hasta Luego Albuquerque! We are off on a new adventure to Cincinnati #NewBeginnings #CincinnatiBound