Thrilled to have been awarded a BBSRC Fellowship! 🎉 An exciting new chapter, continuing in the @carter-lab.bsky.social at @mrclmb.ac.uk – studying how molecular motor function is rewired during cell division. Hugely grateful to Andrew for his support and mentorship 👇 www.ukri.org/news/bbsrc-i...

BBSRC invests in 21 new Fellows

BBSRC invests £10 million in 21 new Fellows as part of its ongoing commitment to develop the next generation of independent research leaders across the UK.

ukri.org

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

@bscb-official.bsky.social Beautiful Cryo-ET talk by Kashish Singh on cytoplasmic lattices in mammalian embryos from @mrclmb.ac.uk at the #DynamicCellVI conference

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

Carter Lab@carter-lab.bsky.social · 5mo ago

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

Today in #journalclub - An isoform of my favourite mitotic adaptor Spindly is repurposed to regulate lipid droplet localisation in interphase. Worth a look 👇 advanced.onlinelibrary.wiley.com/doi/10.1002/...

Excited to share our new paper! 🎉 The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona www.science.org/doi/10.1126/... Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona

The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

science.org

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona

The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

science.org

The power of collaboration (and of in vitro reconstitution)!

Journal of Cell Biology@jcb.org · last yr.

Schweighofer, Mulay, @andrea-musacchio.bsky.social et al. reconstitute direct interactions between FAcilitates Chromatin Transcription and the 16-subunit constitutive centromere–associated network core of the chromatin-proximal #kinetochore rupress.org/jcb/article/... #mitosis

New: Colombo et al. @surreylab.bsky.social show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles https://buff.ly/41aj9F9

Excited to share the first published paper of my postdoc - a collaboration with Yildiz and Dumont groups led by Merve Aslan, on the fascinating dynein adaptor NuMA. Lots of super cool insights on how NuMA can activate dynein during mitosis. Thanks to @carter-lab.bsky.social for the support!

Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo. #CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science

Brilliant and supportive mentor, great location, exciting project - what's not to love? Plus a unique opportunity to really learn from the best at figuremaking!

Ferdos Abid Ali@abidalilab.bsky.social · 2y ago

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

First #JournalClub on the blue side: an exciting story about dynein at the kinetochore and its role in biorientation! www.nature.com/articles/s41...

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore - Nature Communications

Mitotic chromosomes recruit multiple microtubule-directed activities to ensure their faithful segregation. Using an approach where only one major activity is present, the authors reveal sufficiency of...

nature.com