Bharathan, Kowalczyk et al. provide the first comprehensive description of the 3D desmosome in A431 epidermoid carcinoma, human mammary epithelial cells, and airway epithelia in volume electron microscopy datasets. rupress.org/jcb/article/... #Adhesion #StructuralBiology

Olivia P.L. Dalby, Sabrina Simoncelli et al. @ucl.ac.uk use super-resolution imaging and reveal that CAR-T cells assemble immunological synapses with distinct actin architectures, including reduced central clearance and enhanced protrusions. rupress.org/jcb/article/... #Cytoskeleton #Immunology

Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 ubiquitination, From Jianlan Gu, Mingming Yang, Liti Zhang, Chen Hu, Fei Liu, Hengxiang Cui et al.: rupress.org/jcb/article/... 📕 From "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

PARP1 hyperactivity stalls translation and triggers #stressgranule formation following DNA damage. New study from Maria Tereshchenko, Rebecca Earnshaw Hyun O. Lee @utoronto.ca: rupress.org/jcb/article/... #Physiology #CellSignaling #Biochemistry #DNAbiology #DNAdamage

Excited to share our paper, now out in @jcb.org! 🎉 Co-led with @georgegalea.bsky.social at embl.org, we uncover a new layer of spatiotemporal regulation of the #DNADamageResponse between the Golgi and the nucleus, revealing an active role of the Golgi in #DNArepair. doi.org/10.1083/jcb.... 📷by me ❤️

Myeong and Klyachko demonstrate that astrocytic cholesterol release modulates synaptic transmission in an activity-dependent manner to fine-tune the balance and spatial organization of different forms of synaptic exo- and endocytosis. rupress.org/jcb/article/... #CellSignaling #Neuroscience

#Fibroblasts promote osmotic surveillance by wound-induced unique calcium patterns. From László Fazekas, Diána Kaszás, Boldizsár Vámosi, Balázs Enyedi @enyedilab.bsky.social et al. rupress.org/jcb/article/... 📕 From "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

Spatiotemporal regulation of #DNArepair proteins between #Golgi and nucleus maintain genome stability. New study from George Galea @georgegalea.bsky.social, Karolina Kuodyte @kuodyte.bsky.social, Rainer Pepperkok @embl.org and colleagues: rupress.org/jcb/article/... #DNAbiology #Organelles

Liffner, @sabsalon.bsky.social et al. apply Mosquito Tissue Ultrastructure Expansion Microscopy to reveal previously inaccessible details of #Plasmodium sporozoite formation and salivary gland invasion. rupress.org/jcb/article/... #Organelles #Microbiology #CelDivision #Malaria

Are you attending the #FASEB meeting on #Cilia and #Centrosomes and interested in submitting your research to JCB? Get in touch with our Scientific Editor Dan Simon, who will be there! 👉 Email Dan: rupress.org/jcb/pages/ed... @faseborg.bsky.social #CiliaSRC

Autoinhibitory calcium ATPases regulate the calcium gradient required for rapid polarized growth. From Samantha Ryken, Magdalena Bezanilla and colleagues: rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

Mechanical forces stimulate #Golgi export. New study from Chandini Bhaskar Naidu, Javier Vera Lillo, Jean-Baptiste Manneville @upcite.bsky.social, Stéphanie Miserey @institutcurie.bsky.social, Felix Campelo @felixmendu.bsky.social @bist.eu and colleagues: rupress.org/jcb/article/... #Membrane

Our August cover (rupress.org/jcb/issue/22...) shows an immunofluorescence image of LX-2 cells acquired using a Leica Stellaris confocal microscope. Blue, DAPI (DNA); green, type-I collagen, α-1 chain; magenta, TANGO1 (ER exit sites). From Bhattacharyya et al. @crg.eu: rupress.org/jcb/article/...

Nanoscale junctional membrane curvatures recruit BIN1 and SNX9 for endothelial collective migration. New study by Vera Janssen @verajanssen.bsky.social, Ana Angulo-Urarte @aangulou.bsky.social, Stephan Huveneers @huveneerslab.bsky.social et al. @amsterdamumc.bsky.social: rupress.org/jcb/article/...

3D super-res microscopy reveals ultrastructure of asymmetric adherens junctions between leader & follower cells in angiogenesis – BIN1 & SNX9 are regulators 📹 Vera Janssen et al University of Amsterdam in @jcb.org ➡️ bpod.org.uk/archive/2026...

You can dive into the structural details of this composite biomaterial in “Actomyosin cortex integration with complex plasma membrane topography in the early Drosophila embryo.” from @jcb.org doi.org/10.1083/jcb....

Actomyosin cortex integration with complex plasma membrane topography in the early Drosophila embryo

Schematics typically depict the actomyosin cortex below flat PM, but cells have complex PM topographies. Over the early Drosophila embryo, a composite of a

doi.org

Actomyosin cortex integration with complex plasma membrane topography in the early #Drosophila embryo, from Rowan Naidoo, Rebecca Tam, & Tony Harris @uoftcellsysbiol.bsky.social: rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

New review: Yamada, Cruz Walma, and Endo discuss the long nanotubular interconnections termed #cytonemes, #TunnelingNanotubes or #TumorMicrotubes formed by cells to exchange regulatory proteins and organelles for regulating #development, adult homeostasis, and #cancer. rupress.org/jcb/article/...

Zhenjie Wang, Zhe Feng et al. uncover the molecular basis of Ana1-driven #centriole elongation in #Drosophila #spermatogenesis, showing that Ana1/CEP295 promotes longitudinal centriole extension through direct interactions with both Cep135 and #microtubules. rupress.org/jcb/article/...

New paper from our group (Pepperkok Group, EMBL Heidelberg), led together with @kuodyte.bsky.social, where we show how the Golgi complex plays an active role in regulating homologous recombination DNA repair, pointing to DNA repair as a more cell-wide process than previously appreciated.

Journal of Cell Biology@jcb.org · last wk.

@georgegalea.bsky.social, @kuodyte.bsky.social, Pepperkok et al. reveal that RAD51C is anchored at the #Golgi by Giantin until DNA damage triggers ATM-dependent release & nuclear import, establishing the Golgi as a spatiotemporal regulator of nuclear #DNArepair rupress.org/jcb/article/...

Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting. From Dávid Kovács, Bruno Antonny @univcotedazur.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

Are you attending the #FASEB meeting on #Cilia and #Centrosomes and interested in submitting your research to JCB? Get in touch with our Scientific Editor Dan Simon, who will be there! 👉 Email Dan: rupress.org/jcb/pages/ed... @faseborg.bsky.social #CiliaSRC

The missing link: Piccolino is essential for tethering synaptic vesicles to rod #photoreceptor ribbons. New study from Kaspar Gierke, Michalina Gadomska, Johann Helmut Brandstätter and colleagues @fau.de: rupress.org/jcb/article/... #Membrane #lipid #Neuroscience

CAST/ELKS-Endophilin-A interaction ensures synaptic vesicle pool size. New study from Yasunori Mori, Toshihisa Ohtsuka (University of Yamanashi) and colleagues: rupress.org/jcb/article/... #Trafficking #Biochemistry #Neuroscience

In a recent JCB study, Izumi and Furuse (rupress.org/jcb/article/...) uncovered an unexpected signaling function for cell-cell #adhesion proteins in maintaining tissue homeostasis. More from the National Institute for Physiological Sciences, Japan:

Keeping Stem Cells in Check A New Mechanism by Which Cell Junction Proteins Regulate Tissue Homeostasis

Researchers have discovered that smooth septate junction proteins regulate intestinal stem cell prolifera

nips.ac.jp

Tereshchenko, Earnshaw, Lee et al. @utoronto.ca show that #DNAdamage activates cytoplasmic stress responses that promote cell survival. rupress.org/jcb/article/... #Physiology #CellSignaling #Biochemistry #DNAbiology

Endoplasmic reticulum patterns insect cuticle nanostructure. From Sachi Inagaki, Shigeo Hayashi @riken-bdr.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

GCL pruning of PIP3 establishes the soma-germline boundary. New study from Mariyah Saiduddin, Ruth Lehmann @remlehmann.bsky.social and colleagues @whiteheadinstitute.bsky.social @mit.edu: rupress.org/jcb/article/... #StemCells #CellSignaling #Drosophila

How do your cells hold hands when they move together? Find our new publication where the cell membrane, BAR proteins, cell-cell junctions, and the common cardinal vein all dance together to form a healthy vasculature

Journal of Cell Biology@jcb.org · last wk.

Janssen, Angulo-Urarte, et al. @huveneerslab.bsky.social @uva.nl show that nanoscale membrane curvatures at asymmetric endothelial cell–cell junctions serve as a scaffold to recruit BAR proteins, including BIN1 and SNX9, during collective migration. rupress.org/jcb/article/...

@georgegalea.bsky.social, @kuodyte.bsky.social, Pepperkok et al. reveal that RAD51C is anchored at the #Golgi by Giantin until DNA damage triggers ATM-dependent release & nuclear import, establishing the Golgi as a spatiotemporal regulator of nuclear #DNArepair rupress.org/jcb/article/...