Alex Eve

@amjeve.uk

Developmental biologist and Executive Editor of Development @dev-journal.bsky.social. Part of the Node @the-node.bsky.social and The Company of Biologists @biologists.bsky.social. Own views.

Stalked jellyfish are a super rare group of jellies that don't float, but instead anchor themselves to the seafloor using a special 'foot.' To move, they do cartwheels, holding onto the seafloor using sticky pads between their pompom tentacles. 🧪🌿🌊

Pompom tentacles of a staurozoa, by Wkaela robinson from Wikimedia commons Photo by Minette Layne from wikimedia commons, showing the pompom tentacles up close

Mo Weng studies how epithelial cell sheets undergo folding morphogenesis through strong cell-cell connections (adherens junctions), which form 'anchors' that allow cells to contract their surfaces, constricting their shape on one side and thereby bend tissues. #2026SDB Preprint⤵️

gilgamesh, Drosophila casein kinase 1g, is required for myosin-dependent junction strengthening and epithelial folding

Adherens junctions, which serve as the primary physical link between cells, undergo remodeling in response to tension forces to maintain tissue integrity and promote tissue shape changes. However, the in vivo mechanisms driving this process remain poorly understood. Here, we identified Gilgamesh (Gish), the conserved fly homolog of casein kinase 1g as essential for myosin-dependent junction strengthening and tissue folding during apical constriction of Drosophila mesoderm. We show that Gish is recruited to spot adherens junctions in a contractile myosin-dependent manner. During apical constriction, Gish is required for junction strengthening by promoting growth and merging of small junction puncta, as well as stabilizing junction puncta at cell edges. The junction defects in Gish-depleted mesoderm result in breakage of the tissue-scale apical actomyosin network during apical constriction, and ultimately failure in mesoderm infolding. Our data show that Gish is a mechanosensitive kinase required for the integrity of adherens junctions during apical constriction. ### Competing Interest Statement The authors have declared no competing interest.

doi.org

Neha Ahuja studies how pancreatic cell types develop and simultaneously organise and shape into a complex organ, revealing a role for Merlin - a protein that links the cell membrane to intracellular scaffold proteins - in luminogenesis and exocrine acinar cell differentiation. #2026SDB Preprint⤵️

Transient architecture of the embryonic pancreas determines endocrine mass

During organogenesis, epithelial tissues undergo extensive three-dimensional (3D) remodeling while simultaneously generating specialized cell types. Whether these transient architectural states active...

biorxiv.org