James Briscoe

@jamesbriscoe.bsky.social

Developmental Biologist working at the Francis Crick Institute. Neural tube, morphogens, and gene regulatory networks. Editor-in-chief, Development. London · briscoelab.org

Check out my first preprint highlight with @prelights.bsky.social! How cells read the room - coordinated symmetry breaking and proportional cell fate allocation in neural organoids, from Hannah T Stuart et al. Lovely story with solid back-and-forth between modelling and perturbative experiments.

Minimal essential requirements for neural tube self-organisation - preLights

How cells read the room - coordinated symmetry breaking and proportional cell fate allocation in neural organoids

prelights.biologists.com

As Editor of @dev-journal.bsky.social I get asked "What are you doing about your impact factor?" In our new editorial we say: Ask not what Dev can do for the impact factor. Ask what you can do for Dev's IF The IF is about how we all cite, review & assess each other's work doi.org/10.1242/dev....

The elephant in the room: impact factor

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

doi.org

New Review: The notochord From transient embryonic source of morphogen for patterning the neural tube and somites to the cells that persist in intervertebral discs We bring together development, single-cell data and stem cell models of notochord formationn journals.biologists.com/dev/article/...

The notochord: development, disease and stem cell-based modelling

Summary: This Review discusses how developmental and stem cell studies of the notochord can reveal key insights into spine formation and intervertebral disc development and maintenance, providing new ...

journals.biologists.com

New Review: The notochord From transient embryonic source of morphogen for patterning the neural tube and somites to the cells that persist in intervertebral discs We bring together development, single-cell data and stem cell models of notochord formationn journals.biologists.com/dev/article/...

The notochord: development, disease and stem cell-based modelling

Summary: This Review discusses how developmental and stem cell studies of the notochord can reveal key insights into spine formation and intervertebral disc development and maintenance, providing new ...

journals.biologists.com

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org