Cerebrovascular Complications of COVID-19 | Stroke

Background and Purpose: Coronavirus disease 2019 (COVID-19) evolved quickly into a global pandemic with myriad systemic complications, including stroke. We report the largest case series to date of ce...

ahajournals.org

Neurological infection with SARS-CoV-2 — the story so far - Nature Reviews Neurology

As the COVID-19 pandemic developed and neurological manifestations were reported, concern grew that SARS-CoV-2 might directly invade neuronal cells. However, research throughout the year to address th...

doi.org

Neurological consequences of COVID-19 - Pharmacological Reports

In December 2019, cases of pneumonia caused by infection with the previously unknown severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to coronavirus disease 2019 (COVID-19), were identified. Typical manifestations of COVID-19 are fever, cough, fatigue and dyspnoea. Initially, it was thought that the mechanism of action of SARS-CoV-2 was only associated with respiratory tract invasion, but it was later revealed that the infection might involve many other organs and systems, including the central and peripheral nervous systems. Neurological complications associated with SARS-CoV-2 infection include encephalopathy, encephalitis, meningitis, acute disseminated encephalomyelitis (ADEM), ischaemic and haemorrhagic stroke and cerebral venous sinus thrombosis. In cases of peripheral nervous system involvement, smell and taste disorders, myopathy or the signs and symptoms of Guillain‒Barré syndrome are observed. The most common early neurological complications, particularly during the first year of the epidemic, were anosmia and taste disorders, which, according to some studies, occurred in over 80 percent of patients with COVID-19. The proportion of patients with serious neurological manifestations was small compared to the global number of patients, but the numbers of SARS-CoV-2 infections and critical patients increased substantially. The experience from 2 years of the pandemic has shown that approximately 13% of infected patients suffer from severe neurological complications. The relationship between SARS-CoV-2 and the nervous system is not only a cause of neurological complications in previously healthy individuals but also directly and indirectly affects the courses of many nervous system diseases.

doi.org

Neurological Involvements of SARS-CoV2 Infection - Molecular Neurobiology

COVID-19 is a pandemic viral infection caused by a novel coronavirus, SARS-CoV2, which is a global concern of the twenty-first century for its rapid spreading in a short period. Apart from its known a...

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SARS-CoV-2 and the nervous system: current perspectives - Archives of Virology

SARS-CoV-2 infection frequently causes neurological impairment in both adults and children. Recent publications have described significant aspects of the viral pathophysiology associated with neurolog...

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Europäische Kommission genehmigt Marktzulassung des an XFG angepassten COVID-19-Impfstoffs von Pfizer und BioNTech in der Europäischen Union

biontech.com

SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed the interest in the correlation between viral infections and neurodegenerative brain disorders. While many viruses can reach the central nervous system (CNS) causing acute or chronic infections (such as herpes simplex virus 1, HSV-1), the lack of a clear mechanistic link between viruses and protein aggregation into amyloids, a characteristic of several neurodegenerative diseases, has rendered such a connection elusive. Recently, we showed that viruses can induce aggregation of purified amyloidogenic proteins via the direct physicochemical mechanism of heterogenous nucleation (HEN). In the current study, we show that the incubation of HSV-1 and SARS-CoV-2 with human cerebrospinal fluid (CSF) leads to the amyloid aggregation of several proteins known to be involved in neurodegenerative diseases, such as: APLP1 (amyloid beta precursor like protein 1), ApoE, clusterin, α2-macroglobulin, PGK-1 (phosphoglycerate kinase 1), ceruloplasmin, nucleolin, 14-3-3, transthyretin and vitronectin. Importantly, UV-inactivation of SARS-CoV-2 does not affect its ability to induce amyloid aggregation, as amyloid formation is dependent on viral surface catalysis via HEN and not its ability to replicate. Additionally, viral amyloid induction led to a dramatic drop in the soluble protein concentration in the CSF. Our results show that viruses can physically induce amyloid aggregation of proteins in human CSF and result in soluble protein depletion, and thus providing a potential mechanism that may account for the association between persistent and latent/reactivating brain infections and neurodegenerative diseases. Significance Statement Viruses have generally been excluded from the etiology of amyloid pathologies based on the assumption that amyloid formation requires a proteinaceous conformational template (a prion) to form. Here we show that neuroinvasive viruses induce amyloid aggregation of a plethora of proteins in human CSF even after UV inactivation. Our work illustrates that viruses can induce amyloid aggregation of endogenous human proteins in their native environment by acting as physical catalysts of amyloid nucleation and phase transition. Demonstrating this direct mechanistic link, which is independent of templating, can help better understand the link between viruses and neurodegenerative disorders, especially in the post-COVID-19 era. ### Competing Interest Statement Competing interests statement: KE, AS, AJE, SA, and TM are cofounders of REGAIN Therapeutics and co-inventors of some of the company's patents.

doi.org

SARS-CoV‑2 and HSV‑1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

Abstract. The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed inte

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Ins Amt ohne Vereidigung: Merz agiert verfassungswidrig

'Skandalös': Verfassungsrechtler kritisiert Merz, weil die neu ernannten Minister nicht zeitnah in einer Sondersitzung des Bundestages vereidigt werden.

lto.de

Studie: Ölkonzerne verdienen Milliarden am Irankrieg

Die größten fossilen Energiekonzerne verdoppeln laut einer Studie der Entwicklungsorganisation Oxfam ihre Profite – und heizen die Klimakrise an.

taz.de

8.000 Jobs: BMW plant größten Stellenabbau der Konzerngeschichte

Die Stellen sollen bis Ende 2027 weltweit wegfallen, besonders an deutschen Standorten. BMW verspricht, auf betriebsbedingte Kündigungen zu verzichten, und setzt stattdessen auf Abfindungen.

l.euronews.com

Susumu Tonegawa Dies at 86; Nobel Laureate Showed How Antibodies Fight Infection

The first Japanese scientist to win the Nobel Prize in Physiology or Medicine, he went on to discover how memories are stored, advancing understanding of how the brain works.

nytimes.com

Rhein-Tiefstand hat mögliche Folgen für Millionen Haushalte

Der Rhein hat einen sehr niedrigen Wasserstand erreicht, der den Juli-Rekord für Dürrejahre bricht. Dies könnte die Wasserversorgung von Millionen Menschen gefährden.

focus.de

COVID-19 wave in Taiwan expected to peak in early August: CDC - Focus Taiwan

Taiwan's Centers for Disease Control (CDC) said Tuesday that the current COVID-19 wave in the country is expected to peak in early August, earlier than previously forecast.

focustaiwan.tw

Ebola cases in Congo top 3,200, nearing record of the country's worst outbreak

The Ebola outbreak in eastern Congo has surpassed 3,200 cases

abcnews.com

Thread by @SourceControl21 on Thread Reader App

@SourceControl21: 🧵 Viren wie HSV-1 und SARSCoV2 können die Aggregation von Amyloidproteinen im menschlichen Liquor induzieren Viren wirken dabei als Nukleationskatalysatoren für die Amyloidbildung, d...

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Krankenstand im ersten Halbjahr 2026 leicht gesunken

DAK-Gesundheit analysiert Fehlzeiten von 2,2 Millionen Beschäftigten

dak.de

Krankenstand im ersten Halbjahr 2026 leicht gesunken

DAK-Gesundheit analysiert Fehlzeiten von 2,2 Millionen Beschäftigten

dak.de

Trump confronts Carney at World Cup over wildfire smoke: ‘Our air’s being poisoned’

President Donald Trump says he took his Canadian counterpart Mark Carney to task at Sunday’s game between Spain and Argentina, demanding that he bring the natural disaster under control

independent.co.uk

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