Pre-existing cross-subtype serological responses against H5Nx in health care workers journals.asm.org/doi/10.1128/...
Pre-existing cross-subtype serological responses against H5Nx in health care workers | Journal of Virology
Influenza A viruses (IAVs) are endemic in the human population and responsible for hundreds of thousands of deaths every year, occasionally leading to influenza pandemics. Since 2023, there has been a rise in avian IAV infections in humans, with some deaths reported, mostly related to the H5N1 subtype clade 2.3.4.4b. Seasonal vaccines against IAVs are effective, but their efficacy against avian IAVs is not well known. Here, following influenza seasonal vaccination in a cohort of adults, we report highly heterogeneous serological responses, possibly due to pre-existing immunity and HA sequence similarity. These findings provide insight into the breadth of pre-existing and vaccine-induced immunity against H5 influenza viruses and may inform the development of vaccination strategies aimed at providing broader protection against emerging influenza viruses.
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