Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
Ana Fiszbein
@anafiszbein.bsky.social
Molecular and computational biologist. Assistant professor at Boston University in Biology and Computing & Data Sciences. Argentinian www.fiszbeinlab.com
Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...
mRNA initiation and termination are spatially coordinated
Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...
science.org
Thrilled to share our vision of the future of splicing, out today in Nature Reviews Molecular Cell Biology! We think splicing-based therapeutics are ready to cut into the future of personalized medicine www.nature.com/articles/s41...
Visions of the future of molecular cell biology - Nature Reviews Molecular Cell Biology
To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field might look like in 2050. They consider how technological breakthroughs — for exampl...
nature.com
Very excited to share our new paper out now in @MolecularCell. We show how U1 snRNP -a well-known splicing factor- regulates the activity of alternative promoters in human cells www.cell.com/molecular-ce...
U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation
Kim et al. uncover a role for U1 snRNP in regulating internal promoter activity. Beyond its canonical role in splicing, U1 snRNP suppresses premature polyadenylation, enabling upstream transcription t...
cell.com
Proud to introduce our lab’s very first PhD graduate, Dr. Kim (@GyeungYun_Kim)! He defended his thesis today—the same day his first-author paper hit the cover of @MolecularCell. What a way to graduate!
Super excited to see our work on hybrid exon evolution out at @narjournal.bsky.social! academic.oup.com/nar/advance-... 1/6
Hybrid exons evolved by coupling transcription initiation and splicing at the nucleotide level
Abstract. Exons within transcripts are traditionally classified as first, internal or last exons, each governed by different regulatory mechanisms. We rece
academic.oup.com
Migrating here from x.com/anafiszbein. Check out all previous posts from the lab there!