ANDCS
@andcs-asso.bsky.social
Promotes #scientific training programs for #health #students in France, encourages interaction between #MD_PhD trainees and provides them support and networking
[𝗜𝗻𝘁𝗲𝗿𝘃𝗶𝗲𝘄 : 𝗙𝗮𝗻𝗻𝗶𝗲 𝗗𝘂𝗽𝘂𝘆 - 𝗗𝗼𝗰𝘁𝗼𝗿𝗮𝗻𝘁𝗲 𝗮̀ 𝗹’𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁 𝗣𝗮𝘀𝘁𝗲𝘂𝗿] L’ANDCS revient sur youtube pour une 𝗶𝗻𝘁𝗲𝗿𝘃𝗶𝗲𝘄 𝗱𝗲 𝗙𝗮𝗻𝗻𝗶𝗲 𝗗𝘂𝗽𝘂𝘆, étudiante en 𝗱𝗲𝘂𝘅𝗶𝗲̀𝗺𝗲 𝗮𝗻𝗻𝗲́𝗲 𝗱𝗲 𝘁𝗵𝗲̀𝘀𝗲 𝗽𝗿𝗲́𝗰𝗼𝗰𝗲. Elle présente son 𝗽𝗮𝗿𝗰𝗼𝘂𝗿𝘀 en médecine-science et son travail au sein de l’𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁 𝗣𝗮𝘀𝘁𝗲𝘂𝗿. www.youtube.com/@andcs_asso
Nature research paper: Non-invasive profiling of the tumour microenvironment with spatial ecotypes go.nature.com/42USyMo
Non-invasive profiling of the tumour microenvironment with spatial ecotypes - Nature
Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via liquid biopsy and used to profile individual cancers and target treatments.
go.nature.com
Rejoignez-nous le mardi 5 mai 2026 à 19h30, à l’Ecole Normale Supérieur pour écouter le Pr Alain Puisieux, président du directoire de l’Institut Curie et membre de l’académie nationale de médecine et de pharmacie. Inscrivez-vous ici : meet.google.com/puw-bsrn-ywp
A coat of sialylated protein protects human leukemia cells from destruction. Learn more in a new #SciencePerspective: https://scim.ag/48KjX73
The sialic shield of leukemia cells
A coat of sialylated protein protects human leukemia cells from destruction
scim.ag
Le jeudi 16 avril, à l' @normalesup.bsky.social, nous aurons le plaisir d’accueillir nous aurons l’honneur d’accueillir en tandem Julien Guihaire, chirurgien cardiaque, spécialisé en transplantation, et Charles Dariane, chirurgien urologue. Inscrivez-vous ici : meet.google.com/gjy-shut-pww
☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production. bit.ly/40US4Vy
An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis - Nature Cell Biology
Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The e...
bit.ly
Le lundi 16 mars 2026 à 19h30, à l’ @ibensens.bsky.social, nous aurons le plaisir d’accueillir Ghislaine Dehaene-Lambertz, pédiatre et directrice d'une équipe de recherche spécialisée en neurosciences du développement. Inscrivez-vous ici : forms.gle/h9DAsRW2VyGV...
Two new animal studies in #ScienceImmunology show that B cell priming is key to induce broadly neutralizing antibodies (bNAbs) against HIV and demonstrate that a single immunization that targets bNAb precursors can induce potent neutralization. 📃: https://scim.ag/4ahapC0 📃: https://scim.ag/4raNMVz
Zombosomes, large vesicles with cell-like qualities, can spread alpha-synuclein protein clumps from astrocytes to other astrocytes, neurons, and lab-grown brain tissues. Learn more: https://scim.ag/4qSd1vP
An intranasal flu antibody can protect against both influenza A and B in mice and nonhuman primates and is safe in humans, according to new preclinical experiments and two phase one clinical trials published in #ScienceTranslationalMedicine. https://scim.ag/3O5gHM7
Phase 1 and preclinical studies reveal safety, pharmacokinetics, and efficacy of intranasal delivery of the influenza antibody CR9114
Intranasal CR9114 is safe in humans, and twice-daily dosing confers protection against influenza virus challenge in macaques.
scim.ag
Après plusieurs années d'absence, l'𝐀𝐍𝐃𝐂𝐒 𝐞𝐭 𝐥𝐞 𝐌𝐈𝐓 reviennent pour leur 𝐇𝐚𝐜𝐤𝐚𝐭𝐡𝐨𝐧 interdisciplinaire en santé ! 📅 du 𝐯𝐞𝐧𝐝𝐫𝐞𝐝𝐢 𝟏𝟕 𝐚𝐮 𝐝𝐢𝐦𝐚𝐧𝐜𝐡𝐞 𝟏𝟗 𝐚𝐯𝐫𝐢𝐥 𝟐𝟎𝟐𝟔 📍 𝐄𝐩𝐢𝐭𝐞𝐜𝐡 𝐏𝐚𝐫𝐢𝐬, 𝟐𝟒 𝐫𝐮𝐞 𝐏𝐚𝐬𝐭𝐞𝐮𝐫 𝐚𝐮 𝐊𝐫𝐞𝐦𝐥𝐢𝐧-𝐁𝐢𝐜𝐞̂𝐭𝐫𝐞 Voici le lien pour s’inscrire : www.helloasso.com/associations...
A new #ScienceSignaling study connects severe chronic pain and opioid tolerance in #OralCancer to the EGFR signaling pathway, suggesting that repurposing EGFR inhibitors could dampen pain signaling and augment pain relief. https://scim.ag/4k2LQfb
EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer
EGFR signaling in the tissue around oral cancers increases nerve sensitivity and impairs opioid efficacy.
scim.ag
How does ageing influence the way our bodies handle infection? go.nature.com/4sMZuqW
Ageing rewires the body’s tolerance to infection
In life-threatening sepsis, the same signalling pathway that protects young mice from succumbing to organ dysfunction exacerbates damage and lethality in older animals.
go.nature.com
☕Zhang et al. characterize the #mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner #mitochondria membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation. 👉https://rdcu.be/eXjMB bit.ly/3YZ0PNj
MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains - Nature Cell Biology
Zhang et al. characterize the mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner mitochondrial membrane stress by inducing membrane subdomains promoting homeostat...
bit.ly
Inside #macrophages, #Salmonella faces Mg2+ scarcity that disrupts cAMP synthesis & metabolism. @npokorzynski.bsky.social @microbelab.bsky.social &co show that PhoP restores control by promoting Mg2+ uptake & directing cAMP production to sustain growth via CRP @plosbiology.org 🧪 plos.io/3Lcav3T
A paper in Nature presents a detailed map of human chromosomes within the nucleus. This resource provides a foundation for an improved understanding of how the physical layout of human DNA is associated with biological expression. go.nature.com/4pI8knB 🧬 🧪
Astrocytes make up one-quarter of the brain. Nature reports how researchers are learning their value in shaping our behaviour, memory, and health. #Neuroskyence 🧪
The ‘silent’ brain cells that shape our behaviour, memory and health
Astrocytes make up one-quarter of the brain, but researchers are only now realizing their true value.
go.nature.com
Nature research paper: Inhibitors supercharge kinase turnover through native proteolytic circuits go.nature.com/3JWgIk4
Inhibitors supercharge kinase turnover through native proteolytic circuits - Nature
Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.
go.nature.com
Nature research paper: Thalamocortical transcriptional gates coordinate memory stabilization go.nature.com/48CjZy8
Thalamocortical transcriptional gates coordinate memory stabilization - Nature
The sequential recruitment of a thalamocortical transcriptional cascade enables memory maintenance over long timescales.
go.nature.com
The method might one day overcome a key stumbling block faced by gene-editing therapies: the need to design a bespoke treatment for each disease go.nature.com/4a0QoQ6
How to fix genetic ‘nonsense’: versatile gene-editing tool could tackle a host of diseases
Synthetic RNA molecules can program cells to ignore DNA mutations that interfere with protein production.
go.nature.com
L’ANDCS est heureuse de vous proposer un évènement inédit : une soirée de découverte de l’Institut Pasteur se déroulant le jeudi 23 novembre ! Voici le formulaire d'inscription : forms.gle/v8QYsYz7s2q8...
Nature research paper: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death go.nature.com/4hSSG5Q
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death - Nature
CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a therapeutic target.
go.nature.com
Human biomass movement may be up to 40 times greater than that of all land animals combined, according to research in Nature Ecology & Evolution. A second Nature Communications paper finds that wild mammal biomass has more than halved since 1850. go.nature.com/4oID33i go.nature.com/3LhSD7n 🧪
In a meta-analysis of 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full results: nej.md/43U5Ppo #AHA25
Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors, according to a paper in Nature Materials. go.nature.com/4ouOWds 🧪
Le lundi 17 novembre 2025 à 19h30, à l’ @ibensens.bsky.social, nous aurons le plaisir d’accueillir @lacombekarine.bsky.social , professeure des universités - practicienne hospitalière (PUPH) en infectiologie à @sorbonne-universite.fr. Inscrivez-vous ici : forms.gle/iguhqmQndjw1...
A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors. #medsky 🧪
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
go.nature.com
Researchers in #ScienceTranslationalMedicine present a new method to generate stable, antigen-specific regulatory #Tcells in large quantities using the body’s own conventional T cell pool, and show the resulting cells can treat IBD and GvHD in mouse models. https://scim.ag/47dDYBm
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
scim.ag
In low-risk patients with severe aortic stenosis, transcatheter and surgical aortic-valve replacement had similar 7-year survival and valve durability outcomes, with no evidence of differences in composite end points. Full PARTNER 3 trial results: nej.md/4nieHfx #TCT2025 | @crfheart.bsky.social
Nature research paper: Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion go.nature.com/4nlQFQK
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled in the faeces.
go.nature.com