Andrea Morandi

@andreamorandi.bsky.social

Full Professor of Molecular Biology and PI of the Tumour Biochemistry Lab @UNIFI | Head of the Breast Unit Translational Lab @AOUC https://www.sbsc.unifi.it/vp-326-gruppo-morandi.html https://www.ncbi.nlm.nih.gov/myncbi/1JM7xFr2A8y56/bibliography/public

๐Ÿ“ฃ Itโ€™s been a productive few days for our group! ๐Ÿ’กOur new paper in ๐˜Š๐˜ฆ๐˜ญ๐˜ญ ๐˜‹๐˜ฆ๐˜ข๐˜ต๐˜ฉ & ๐˜‹๐˜ช๐˜ด๐˜ฆ๐˜ข๐˜ด๐˜ฆ shows that lead nitrate drives NRF2-dependent metabolic reprogramming and proliferation in hepatocytes. With Universitร  di Cagliari & Universitร  di Torino, funded by MUR#PRIN2022. ๐Ÿ”— www.nature.com/articles/s41...

Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes - Cell Death & Disease

Cell Death & Disease - Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes

nature.com

๐Ÿšจ Our new paper is now out in ๐˜Š๐˜ข๐˜ฏ๐˜ค๐˜ฆ๐˜ณ ๐˜™๐˜ฆ๐˜ด๐˜ฆ๐˜ข๐˜ณ๐˜ค๐˜ฉ! ESR1 mutations in ERโบ breast cancer rewire lipid metabolism, creating a ferroptosis vulnerability ๐Ÿ”ฌ ACSL4 is a key biomarker & combo with SERDs offers a new strategy. ๐Ÿ‘ Congrats to the whole #TBTlab & collaborators! aacrjournals.org/cancerres/ar...

ESR1 Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer

Abstract. Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancer. Point mutations in the ligand-binding domain of the gene encoding the estrogen receptor (ES...

aacrjournals.org