Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract | NEJM

In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infectio...

nejm.org

𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘: 𝗖𝗠𝗙𝗜 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 2027 📍 Tübingen, Germany 🗓️ February 17–19, 2027 The CMFI Conference returns in 2027, bringing together researchers from microbiology… | CMFI - Cluster of Excellence

𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘: 𝗖𝗠𝗙𝗜 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 2027 📍 Tübingen, Germany 🗓️ February 17–19, 2027 The CMFI Conference returns in 2027, bringing together researchers from microbiology, infection biology, metabolomics a...

linkedin.com

mSphere Legacy: Fritz about Fritz | mSphere

I began my research career in the late 1970s with my doctoral thesis at LMU Munich under Karl Heinz Schleifer in the Department of Microbiology. At the time, the department was a hotspot for bacterial...

journals.asm.org

Olymvax：Did a Chinese Biotech Just Solve One of the Toughest Problems in Vaccine Development?

For more than two decades, Staphylococcus aureus vaccines have been considered one of the most frustrating challenges in vaccinology. The rationale seemed straightforward.

linkedin.com

A broadly conserved gram-positive lipoprotein regulates cell elongation | PNAS

The cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carr...

pnas.org

Genetic basis of glycine and L-serine toxicity in Staphylococcus aureus and the case for glycine as an antibiotic adjuvant

The toxicity of the amino acids glycine and L-serine at high concentrations in bacteria was discovered decades ago. In this work, we used deep transposon insertion sequencing (Tn-seq) experiments to d...

biorxiv.org

Viruses against bacteria: EU funds phage therapy with €15 million | German Center for Infection Research

Bacteria are becoming increasingly resistant to antibiotics. One alternative is treatment with viruses that exclusively infect bacteria, known as phages.

t1p.de

Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field

rdcu.be

Metabolic reprogramming promotes Staphylococcus aureus serum resistance

Staphylococcus aureus is a leading cause of bloodstream infections causing an estimated 300,000 deaths worldwide. Using a functional genomics approach, our group previously identified that adaptation ...

microbiologyresearch.org

biorxiv.org

FabF and FadM cooperate to recycle fatty acids and rescue ∆plsX lethality in Staphylococcus aureus

Author summary Phospholipids are vital cell membrane components. The essential Staphylococcus aureus phospholipid synthesis enzyme PlsX uses acyl-ACP, the end-product of fatty acid (FA) synthesis (FAS...

dx.plos.org

Targeting phenol-soluble modulin α3-driven M1 macrophage polarization and necroptosis mitigates MRSA infection in mice - Nature Communications

Methicillin-resistant Staphylococcus aureus (MRSA) is a key pathogenic bacterium and poses a significant therapeutic challenge due to its developing resistance to therapeutics. Here the authors establ...

nature.com

Independent Junior Research Group Leaders (m/f/d) - Tübingen, Baden-Württemberg (DE) job with Eberhard Karls Universität Tübingen | 12858473

The Cluster of Excellence EXC 2124 “Controlling Microbes to Fight Infections” (CMFI) at the University of Tübingen invites applications for Indepen...

nature.com

Genetic modification of intractable bacterial clones by heat shock-facilitated phage transduction

Increasing recognition of commensal bacteria as essential for microbiome integrity and pathogen exclusion underscores the urgency of molecularly chara…

sciencedirect.com

Transposable elements are driving rapid adaptation of Enterococcus faecium - Nature

Over three decades, rapid expansion of the transposable element ISL3 has reshaped Enterococcus faecium, which helps to explain this pathogen’s growing clinical threat.

nature.com

Transposable elements are driving rapid adaptation of Enterococcus faecium - Nature

Over three decades, rapid expansion of the transposable element ISL3 has reshaped Enterococcus faecium, which helps to explain this pathogen’s growing clinical threat.

nature.com

Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia

Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!

keysym.us

A teichoic acid-like wall modification associated with immune suppression is socially regulated in Streptococcus pyogenes | mBio

Streptococcus pyogenes is a major human pathogen, responsible for diverse clinical manifestations of both superficial and invasive infections, and can lead to post-infection sequelae like rheumatic heart disease, whose prevalence on a global scale rivals that of the most serious pathogens. Invasive S. pyogenes infections are currently on the rise worldwide, notably correlating with increasing pediatric cases of scarlet fever and enhancing the concern for long-term complications. There is much that remains unknown about S. pyogenes virulence and pathogenicity, and studies focused on understanding basic systems regulating virulence factors could lead to better therapeutics and translational research. We show here one such example, where a bacterial communication system regulating a virulence mechanism relevant to in vivo infection confers the ability to alter the host’s innate immune response. We find that modifications to the cell wall arise when this virulence system is activated, which has a direct role in host-pathogen interactions. Further research into this system could provide a mechanism for disruption and serve to treat S. pyogenes infection.

journals.asm.org

Advancing microbiology through foundational science - Nature Microbiology

Microorganisms have tremendous potential to impact humanity, but such revelations are only possible in the light of foundational, discovery-based microbiology research.

nature.com

Planetary microbiome structure and generalist-driven gene flow across disparate habitats

A planetary-scale analysis of over 85,000 metagenomes establishes a framework for exploring the structure and drivers of global microbial habitats, revealing that generalist species bridge ecological boundaries to mediate gene flow across disparate habitats, including the dissemination of antimicrobial resistance.

cell.com

Frontiers | First genome sequence and functional profiling of Psychrobacter SC65A.3 preserved in 5,000-year-old cave ice: insights into ancient resistome, antimicrobial potential, and enzymatic activi...

IntroductionAncient cryospheric environments may preserve overlooked reservoirs of antimicrobial resistance (AMR) and bioactive potential. This study reports...

frontiersin.org

Polygenic, cell-envelope adaptations drive high-frequency daptomycin resistance in Staphylococcus capitis NRCS-A from neonatal sepsis and NEC | Antimicrobial Agents and Chemotherapy

The increasing incidence of bloodstream infections caused by multi-resistant bacteria presents a major global health burden, complicating the treatment of patients facing sepsis and resulting in incre...

journals.asm.org

The anatomy and molecular inventory of Staphylococcus aureus abscesses

Staphylococcus aureus is an opportunistic pathogen that infects practically every body site despite differences in nutritional environment, immune milieu, and mode of inoculation. S. aureus abscesses are pathophysiological structures wherein host-derived extracellular matrix and immune cells form layers surrounding a S. aureus colony. Staphylococcal abscess communities seed staphylococcal abscesses, which are associated with worse S. aureus infection outcomes. Abscesses are also an example of the host–S. aureus interface, wherein host and pathogen adaptations define the spatial and temporal features of pathogenesis as well as the outcomes of infection. This review discusses recent discoveries in abscess formation made across organ systems and highlights findings involving host and pathogen determinants of abscess formation that improve our understanding of S. aureus pathogenesis.

dlvr.it