Beyond wrinkles

Can the skin microbiome shape healthy aging?

science.org

Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation

Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...

cell.com

A genome-wide genetic interaction platform for MRSA reveals connections between cell division and the cell envelope

The bacterial cell cycle is an ensemble of integrated pathways that coordinates cell growth and division. Although these pathways contain a suite of promising antimicrobial targets, their functional o...

biorxiv.org

A c-di-AMP-controlled glutamine synthesis pathway promotes persistence of Staphylococcus aureus thymidine-dependent small colony variants in the lung

Children with cystic fibrosis (CF) commonly harbor Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs), which are associated with reduced lung function and increased respiratory ...

biorxiv.org

Cyclic di-AMP signaling and regulation in Staphylococcus aureus | mSphere

Bacteria are continuously exposed to diverse environmental changes and stresses. They are especially susceptible to such stimuli and therefore rely on efficient regulatory systems to sense and adapt r...

journals.asm.org

Staphylococcus aureus Mnh1 cation–proton antiporter promotes phagocytic uptake and intracellular survival in human monocytes

While Staphylococcus aureus is predominantly an extracellular human commensal, it can also exhibit an intracellular lifestyle that enables its persistence within diverse host cell types, including mon...

biorxiv.org

A hierarchical regulatory cascade defines the temporal window of natural transformation in Staphylococcus aureus

Natural transformation (NT), a major mechanism of horizontal gene transfer, promotes bacterial genome plasticity and contributes to the dissemination of antibiotic resistance. NT requires the developm...

biorxiv.org

Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract | NEJM

In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infectio...

nejm.org

𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘: 𝗖𝗠𝗙𝗜 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 2027 📍 Tübingen, Germany 🗓️ February 17–19, 2027 The CMFI Conference returns in 2027, bringing together researchers from microbiology… | CMFI - Cluster of Excellence

𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘: 𝗖𝗠𝗙𝗜 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 2027 📍 Tübingen, Germany 🗓️ February 17–19, 2027 The CMFI Conference returns in 2027, bringing together researchers from microbiology, infection biology, metabolomics a...

linkedin.com

mSphere Legacy: Fritz about Fritz | mSphere

I began my research career in the late 1970s with my doctoral thesis at LMU Munich under Karl Heinz Schleifer in the Department of Microbiology. At the time, the department was a hotspot for bacterial...

journals.asm.org

Olymvax：Did a Chinese Biotech Just Solve One of the Toughest Problems in Vaccine Development?

For more than two decades, Staphylococcus aureus vaccines have been considered one of the most frustrating challenges in vaccinology. The rationale seemed straightforward.

linkedin.com

A broadly conserved gram-positive lipoprotein regulates cell elongation | PNAS

The cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carr...

pnas.org

Genetic basis of glycine and L-serine toxicity in Staphylococcus aureus and the case for glycine as an antibiotic adjuvant

The toxicity of the amino acids glycine and L-serine at high concentrations in bacteria was discovered decades ago. In this work, we used deep transposon insertion sequencing (Tn-seq) experiments to d...

biorxiv.org

Viruses against bacteria: EU funds phage therapy with €15 million | German Center for Infection Research

Bacteria are becoming increasingly resistant to antibiotics. One alternative is treatment with viruses that exclusively infect bacteria, known as phages.

t1p.de

Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field

rdcu.be

Metabolic reprogramming promotes Staphylococcus aureus serum resistance

Staphylococcus aureus is a leading cause of bloodstream infections causing an estimated 300,000 deaths worldwide. Using a functional genomics approach, our group previously identified that adaptation ...

microbiologyresearch.org

biorxiv.org

FabF and FadM cooperate to recycle fatty acids and rescue ∆plsX lethality in Staphylococcus aureus

Author summary Phospholipids are vital cell membrane components. The essential Staphylococcus aureus phospholipid synthesis enzyme PlsX uses acyl-ACP, the end-product of fatty acid (FA) synthesis (FAS...

dx.plos.org

Targeting phenol-soluble modulin α3-driven M1 macrophage polarization and necroptosis mitigates MRSA infection in mice - Nature Communications

Methicillin-resistant Staphylococcus aureus (MRSA) is a key pathogenic bacterium and poses a significant therapeutic challenge due to its developing resistance to therapeutics. Here the authors establ...

nature.com

Independent Junior Research Group Leaders (m/f/d) - Tübingen, Baden-Württemberg (DE) job with Eberhard Karls Universität Tübingen | 12858473

The Cluster of Excellence EXC 2124 “Controlling Microbes to Fight Infections” (CMFI) at the University of Tübingen invites applications for Indepen...

nature.com

Genetic modification of intractable bacterial clones by heat shock-facilitated phage transduction

Increasing recognition of commensal bacteria as essential for microbiome integrity and pathogen exclusion underscores the urgency of molecularly chara…

sciencedirect.com

Transposable elements are driving rapid adaptation of Enterococcus faecium - Nature

Over three decades, rapid expansion of the transposable element ISL3 has reshaped Enterococcus faecium, which helps to explain this pathogen’s growing clinical threat.

nature.com

Transposable elements are driving rapid adaptation of Enterococcus faecium - Nature

Over three decades, rapid expansion of the transposable element ISL3 has reshaped Enterococcus faecium, which helps to explain this pathogen’s growing clinical threat.

nature.com