Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome. Beautiful cover art too! @jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social

Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.

science.org

Recently published work lead by the very talented @dvillarroelc.bsky.social. Lots of work has gone in to this and I have enjoyed seeing this story develop over the years. Congrats to all! @jamessleigh.bsky.social @joburrito.bsky.social @frattalab.bsky.social @uclqsion.bsky.social #axonaltransport

Life Science Alliance@lsajournal.org · 6mo ago

Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7. www.life-science-alliance.org/content/9/4/...

Do all #NTFs regulate #MotorNeuron axonal transport in vivo? Our new preprint shows they do not. #BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect. #AxonalTransport regulation is selective, not universal. @jamessleigh.bsky.social @uclqsion.bsky.social

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 10mo ago

CNTF specifically slows down the axonal transport of signalling endosomes https://www.biorxiv.org/content/10.1101/2025.10.09.681259v1

A wonderful collaboration. Congratulations to @nicolbirsa.bsky.social & @beccasimkin.bsky.social and all the co-authors #axonaltransport #FUS #MND #ALS #NMJ

Nicol Birsa@nicolbirsa.bsky.social · last yr.

Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model! www.biorxiv.org/content/10.1... @uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social

Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.sciencedirect.com/science/arti... @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age

A healthy nervous system is reliant upon an efficient transport network to deliver essential cargoes throughout the extensive and polarised architectu…

sciencedirect.com

James N. Sleigh@jamessleigh.bsky.social · 2y ago

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.biorxiv.org/content/10.1... Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al. @uclqsion.bsky.social #aging

🚨New @biorxivpreprint.bsky.social collab b/w Fisher, Cunningham, Gilthorpe & Schiavo Labs. @mrcharwell.bsky.social @uclqsion.bsky.social @umeauniversitet.bsky.social Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel humanised SOD1A4V mice. t.co/u01CG6ctTS

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.biorxiv.org/content/10.1... Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al. @uclqsion.bsky.social #aging

A little about me! 🦋 With help from Scholar Goggler scholargoggler.com

I will try to take on the challenge to highlight some of the cool bioimage analysis tools we use all the time. #BioimageTooloftheDay I will start with ijp-LaRoMe, a very nifty Fiji plugin that I use all the time to convert ROI to label images and vice versa github.com/BIOP/ijp-LaR...

Looking forward to AXON2025 - mark your calendars