What if a membrane protein’s movement is as important as what it does? Our latest work reveals the unrestricted lateral mobility of a rhomboid protease enables neuronal synapse remodelling tinyurl.com/yk6xfxzr All credit to @annabodzeta.bsky.social for this stunning work, who is on the job hunt!

Here it is my 1st preprint about synapse and rhomboid intramembrane protease: www.biorxiv.org/content/10.6... Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2

The unhindered lateral mobility of a rhomboid intramembrane protease enables synapse remodelling

Synapses must maintain their stable molecular organisation while retaining the capacity to remodel in response to changing demands. In order to flexibly change synaptic strength, the abundance of tran...

biorxiv.org

The unhindered lateral mobility of a rhomboid intramembrane protease enables synapse remodelling https://www.biorxiv.org/content/10.64898/2026.09.10.750656v1

While waiting for the manuscript to be uploaded on bioRxiv, here some sneak peek #FluorescenceFriday

#Neurons are amazing! #Actin is amazing! #FluorescenceFriday

One microscope to rule them all

Nature Methods@natmethods.nature.com · 4mo ago

MOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @supgokul.bsky.social www.nature.com/articles/s41...

One of the best, most inspiring imaging conference I've ever attended. Great science, great scientists, great location and great ... food. Big thanks to all people involved.

Journal of Cell Science@jcellsci.bsky.social · 5mo ago

That’s a wrap for #JCSimaging, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti. Thanks to everyone who joined us and made the conference such a wonderful community event. journals.biologists.com/jcs

Kinase-gated coincidence detection controls kinesin-driven lysosome transport https://www.biorxiv.org/content/10.64898/2026.03.27.714776v1

Exciting conference alert! The 93rd Biochemical Society Harden Conference will be on "Endosomal-lysosomal network dysfunction in neurodegeneration" on the South coast of England (1st to 4th of September 2026). Lots of speaker slots available from submitted abstracts so do come and join us!

Add our first pre-print to your reading list? Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social! Please share: tinyurl.com/3h8r7f5y

''Understanding how techniques work is essential to getting good images in the first place.'' 100% agree.

Elisabeth Bik@elisabethbik.bsky.social · last yr.

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. @sarareardon.bsky.social reports www.nature.com/articles/d41...

Come and join us in solving mystery of plasma membrane proteostasis in beautiful neurons.

adam grieve@adamgrieve.bsky.social · last yr.

Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!