What if the segmentation clock does more than tell an embryo when to make a segment? In our new paper in @cp-devcell.bsky.social, we show that it also helps coordinate tissue growth with segmentation, promoting robust somite formation! 🧵👇 www.cell.com/developmenta...

Very saddened by the lost of Marta. Seconds after talking to her for the first time, my initial intimidation became permanent admiration. Marta was kind, intelligent, and passionate about science and her family. She brought a lot of us together, together we remain ❤️ ileon.eldiario.es/actualidad/l...

Las autoridades confirman la muerte de la bióloga molecular leonesa, Marta Shahbazi, en el accidente de Urda

La científica de 41 años en Cambridge, hija de un refugiado iraní de los ayatolás y vinculada a Carrizo de la Ribera por su madre, es sobrina de la biofarmacéutica de León y premio nacional de Ciencia...

ileon.eldiario.es

Why do big dogs have short lifespans than little dogs? @science.org www.science.org/doi/10.1126/...

Epigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs

The extraordinary lifespan variation in domestic dogs provides a natural experiment for testing how intrinsic rates of biological aging shape lifespan. Using 1640 methylomes from 894 dogs, we develope...

science.org

my heart lies in academia... but omg this job can be difficult.

How do DNA sequence features tune the timing, level or duration of gene expression? Join us for a 4 year PhD @mrc-lms.bsky.social with @perez-carrasco.bsky.social @jamesware.bsky.social to build models and help us better predict the impact of non-coding sequence variation #devbio #quantitativebio👇

Ruben Perez-Carrasco@perez-carrasco.bsky.social · 4w ago

📣 New PhD position in our lab with @vmetzis.bsky.social zis.bsky.social and @jamesware.bsky.social. Join us to uncover how regulatory elements control the timing and dynamics of gene expression. Interested in gene regulation, development and quantitative biology? 👇 www.findaphd.com/phds/project...

Did you ever want to sequence that one interesting cell you observed in your microscopy experiment? We have a new pre-print out today that describes a genetic barcoding method, Waldo, to perform live-cell imaging and single-cell sequencing on the same single cells. www.biorxiv.org/content/10.6...

Linking live-cell imaging to single-cell sequencing using genetic barcoding

Linking cellular phenotype to genotype and gene expression is a central goal in biomedical research. Live-cell imaging captures dynamic cellular phenotypes, whereas single-cell sequencing measures gen...

biorxiv.org

In preprints – the embryo, the placenta and lessons from developmental metabolism @bernasozen.bsky.social explores how recent #preprints by Aguilera-Castrejon et al. & Xu et al. reveal metabolic roles for embryonic and extra-embryonic tissues during mid-gestation. doi.org/10.1242/dev....

In preprints – the embryo, the placenta and lessons from developmental metabolism

This article discusses the preprinted work of Lokshtanov and colleagues (Lokshtanov et al., 2026 preprint) as well as that of Xu and team (Xu et al., 2026 preprint). As preprints, these works have…

doi.org

‼️ Postdoc position open. We study how protein metabolism controls time. If you’re excited by this question, we’d love to hear from you! We’re looking for a motivated & collaborative researcher with a strong track record. 📅 30 September 2026 📢 Please share Apply here 👇👇

Postdoctoral Research Scientist - Babraham

The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...

babraham.current-vacancies.com

🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇

Noncoding transcription controls the developmental dynamics of long-range gene regulation

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

science.org

Our Special Issue on the Extracellular Environment is now complete! #DevSIextracellular. Guest-edited by @hugheslabpenn.bsky.social & @rashmi-priya.bsky.social, it contains 34 articles in total. Explore more here: tinyurl.com/bdr4ymvr

OpenAI claims it has solved the Navier-Stokes problem. Here’s a quick rundown of what’s known so far about this apparent breakthrough—and the surrounding controversy: https://scim.ag/4ytDoM0

Pre-print alert!! Did you know that exploration of loss and gain of eQTL regulation in normal versus disease condition from scRNAseq can reveal pos-transcriptional regulatory mechanisms (e.g. miRNA)? Have a look at our work, led by awesome @tdwinter.bsky.social, in which we focus on human islets.

bioRxiv Genetics@biorxiv-genetic.bsky.social · 2y ago

Cell type-specific eQTL detection from single-cell RNA-seq reveals post-transcriptional regulatory mechanisms in human islets https://www.biorxiv.org/content/10.1101/2025.01.21.633530v1