@ansarilab.bsky.social
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
New JACS paper from the Blair Lab! pubs.acs.org/doi/10.1021/... @stjuderesearch.bsky.social
Direct-to-Biology Enabled Molecular Glue Discovery
Molecular glues powerfully control protein proximity but have largely eluded direct screening. A promising avenue for addressing this challenge lies within pinpointing the fundamental features for function-first identification of molecular gluing events. In the widely accepted mechanism, a molecular glue stabilizes two proteins within a ternary complex─here, we show how differences in affinity for ternary and binary complexes directly categorize glues from nonglues. We leverage these differences together with high-throughput chemical synthesis and affinity-selection mass-spectrometry to discover a molecular glue from a suite of over 20,000 crude chemical reaction mixtures. Orthogonal assays robustly support the identification of molecular glues via ternary complex stability. Our findings suggest that a roadmap for de novo molecular glue discovery lies within kinetic profiling of unpurified mixtures of small organic molecules against protein pairs.
pubs.acs.org
Another new paper alert fro CBT! Andrew Huber in the Chen Lab published work on degradation of nuclear receptors. nature.com/articles/s41... @StJudeResearch #DrugDiscovery
PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors - Nature Communications
Chemically induced protein degradation is a powerful alternative to classical inhibition, but some proteins have deeply masked binding pockets that make the development of degrader molecules difficult...
nature.com
Excellent research out of the Lee Lab by @stjudegraduate student Hannah Snoke! bit.ly/SnokeACSID25 @stjuderesearch.bsky.social #infectiousdiseases #DrugDiscovery
Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
bit.ly
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab! bit.ly/Dabas_Pol2
Kinase atlas uncovers hidden layers of cell signaling regulation
See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.
bit.ly
Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.
St. Jude is hosting its annual Bringing Chemistry to Medicine Symposium October 2-3, 2025, in Memphis, TN. In collaboration with @cellpress.bsky.social, the event features global experts sharing cutting-edge advancements at the intersection of chemical and biomedical sciences.
Are you a #drughunter looking to have a direct impact on patients? The Department of Chemical Biology and Therapeutics is seeking a Principal Scientist in Chemical Induced Proximity to lead a new group. talent.stjude.org/careers/jobs...
Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!
talent.stjude.org
Are you a #drughunter looking to have a direct impact on patients? The Department of Chemical Biology and Therapeutics is seeking a Principal Scientist in Chemical Induced Proximity to lead a new group. talent.stjude.org/careers/jobs...
Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!
talent.stjude.org
We're hiring! CBT is seeking a principal scientist to led efforts in induced proximity strategies for drug discovery. Join our highly collaborative team! talent.stjude.org/careers/jobs...
Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!
talent.stjude.org
Had a blast writing this piece celebrating the latest paper in @pubs.acs.org from @ellensletten.bsky.social and Ellen’s general awesomeness. My 11-year old daughter was my coauthor! (try to find all the Easter Eggs) pubs.acs.org/doi/10.1021/...
Stars by the Pocketful
SWIR dyes─The Eras Tour. This love story between chemistry and biology shines.
pubs.acs.org
