Estimating the time course of biomarker changes in Alzheimer’s disease academic.oup.com/brain/articl...
Antoine Garnier-Crussard
@antoinegc.bsky.social
Geriatrician (memory clinic physician, Hospices Civils de Lyon, France) and researcher (associate professor, Université Lyon 1). MD PhD #Alzheimer #LewyBody #WMH #Neuropsychology #Biomarkers #Frailty #IntrinsicCapacity
🗣️🎙️🖥️🧠Automated Speech Analysis to Identify Clinical, Anatomical, and Pathological Variants of Primary Progressive Aphasia 👉AUC 0.90 to distinguish speech profiles & discriminate neuropathology interesting, 'in settings where specialized speech-language assessment is limited' shorturl.at/W1CWv
Automated Speech Analysis in Primary Progressive Aphasia
This cross-sectional study investigates if automated analysis of connected speech can distinguish primary progressive aphasia variants and reflect neuroanatomical and neuropathologic substrates.
shorturl.at
👉Déprescrire chez les personnes âgées cognitivement vulnérables : adaptation française des critères STOPPCog 🧠💊 Bravo 🙏👏 @teddynovais.bsky.social et l'équipe ! www.jle.com/fr/revues/gp...
🚨 Paper alert 👉 White matter hyperintensities in Alzheimer's disease in the era of anti-amyloid therapies 🔓 Link to the (open access) paper = lnkd.in/dGx6hh9g 🧵👇 (1/)
Breakpoints in Alzheimer's disease biomarkers and cognition across the aging spectrum: The Mayo Clinic Study of Aging alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
ICYMI: New online! The potential of low-field MRI for global dementia care
The potential of low-field MRI for global dementia care
Nature Reviews Neurology, Published online: 07 April 2026; doi:10.1038/s41582-026-01199-7The prevalence of dementia is rising in low-income and middle-income countries, but access to advanced diagnostic and research tools such as neuroimaging remains severely restricted in these regions. This Review highlights the potential of low-field MRI as an accessible alternative to conventional imaging in resource-limited settings.
dlvr.it
🚨Paper Alert Happy to share this paper led by A. Flaus & C. Gayor on dual isotope SPECT in dementia with Lewy bodies : one exam, two informations !! With dopamine transporter and perfusion imaging in a single session (CZT SPECT) 🔓 Open access paper shorturl.at/RhvtF
Spatial navigation in preclinical Alzheimer's disease: A review New review from @antoinegc.bsky.social and @antoinecoutrot.bsky.social labs, on which I am a co-author, and first author is the amazing Syrine Salouhou arxiv.org/abs/2603.23082
⚠️New review straight out of the oven! "Spatial navigation in preclinical Alzheimer's disease: A review" arxiv.org/abs/2603.23082 We focus on spatial navigation as a sensitive cognitive marker in preclinical AD, compiling evidence from cognitively unimpaired individuals with positive AD biomarkers.
🚨Happy to share this paper "Associations between frailty, biomarkers of cerebral pathology, cognitive and neuropsychiatric symptoms: a memory clinic study" 👉 Dementia is a complex syndrome : both brain lesions and general state of frailty are associated with clinical phenotype shorturl.at/Tz4Xy
Why do many folks lose weight with Parkinson’s disease? The biology is more complex than eating less. New paper in Movement Disorders how multiple biological pathways combine to drive weight loss in Parkinson’s disease.
Honored to share our work on #Parkinsons in the journal Movement Disorders! In sporadic and genetic PD, patients with synuclein SAA+ PD have more striatal DAT deficit relative to atrophy while those with synuclein SAA- PD have more striatal atrophy relative to DAT deficit. doi.org/10.1002/mds....
🚨 Publication Our letter to the editor is published in Alzheimer's and Dementia DADM @alzdemjournals.bsky.social A French qualitative study on GPs' perceptives on AD BBM ! alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
www.nature.com/articles/s41...
The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial - Nature Medicine
In this phase 2, randomized trial in early Alzheimer’s disease, the TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical De...
nature.com
📢 New Preprint “Cardiac amyloidosis and the risk of Alzheimer’s disease: a population-based nested case–control study”, using the French National Health Data System #SNDS N=96000 ⚡individuals with ATTR-CM had a lower likelihood of AD aOR: 0.65, 99% CI: 0.56–0.75 🔗 lnkd.in/d7GGYNQH
This link will take you to a page that’s not on LinkedIn
lnkd.in
In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer's disease continuum www.nature.com/articles/s41...
In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuum - Molecular Psychiatry
Molecular Psychiatry - In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuum
nature.com
🚨 Paper Alert 🚨 💡If you are interested in the locus coeruleus and dementia with Lewy bodies, this systematic review, led by @sophiedautricourt.bsky.social 👏, is for you! 🔓 shorturl.at/b3ws2 @robindeflores.bsky.social @claireandre.bsky.social @hcl-recherche.bsky.social @neuropresage.bsky.social
🚨 I share this case report, describing a case of late-onset dementia, associated with a likely pathogenic COL4A2 variant 👉 Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report www.sciencedirect.com/science/arti...
Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report
Cerebral small vessel disease can manifest as vascular dementia, typically associated with vascular risk factors or cerebral amyloid angiopathy, and m…
sciencedirect.com
🧠 🚨 New publication in Scientific Reports ! 👉 Heterogeneity of white matter hyperintensities in Alzheimer’s disease captured by multimodal neuroimaging www.nature.com/articles/s41... 👉 We studied MRI (T1w, T2w) and PET (18F-florbetapir and 18F-FDG) signals within WMH in 142 older adults
🚨Postdoc position open at @BarcelonaBeta🚨 We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠 Fully funded position!!! More details: www.imim.cat/media/upload... Please share! #Alzheimer's #ENDALZ
imim.cat
🚨 Happy to share our commentary, on Sacubitril/Valsartan, Heart Failure and Risk of Dementia 🧠💊❤️ link.springer.com/article/10.1... The original paper link.springer.com/article/10.1... Our review in 2024 on this topic: alzres.biomedcentral.com/articles/10.... 🆘Brain & Heart health are connected 🧠❤️
🚨VasCog-2🚨 👉 Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria 🧠🩸🧠 jamanetwork.com/journals/jam...
Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia
This Delphi study aimed to reach international consensus on the diagnosis of cognitive impairment and dementia via a revision of the International Society for Vascular Behavioural and Cognitive Disord...
jamanetwork.com
🚨 Paper Alert Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠 🔓 www.sciencedirect.com/science/arti...
🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders 🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD 💥 program online lnkd.in/dhhaAytZ @hcl-recherche.bsky.social
🧠🩺Comorbidities and comorbidity burden in patients with neurocognitive disorders 👉A detailed, in-depth study of comorbidities (individual comorbidities and comorbidity indices) in >3000 real-life patients seen in memory clinics💡 @hcl-recherche.bsky.social link.springer.com/article/10.1...
⛲💦🚰 👉"In this cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days."
Whether lactated Ringer’s solution is clinically superior to normal saline for routine intravenous administration of fluids to hospitalized patients is unclear. Research findings from the FLUID trial are summarized in a new Quick Take video. nej.md/4oCRgQ4 #MedSky #CriticalCare
🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders 🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD 💥 program online lnkd.in/dhhaAytZ @hcl-recherche.bsky.social
🧠🩸Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis www.sciencedirect.com/science/arti...
Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
Plasma phosphorylated tau (p-tau) biomarkers show promise to transform the clinical management of Alzheimer's disease by providing more accessible and…
sciencedirect.com
🚨 Paper Alert Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠 🔓 www.sciencedirect.com/science/arti...