🚨 Publication Our letter to the editor is published in Alzheimer's and Dementia DADM @alzdemjournals.bsky.social A French qualitative study on GPs' perceptives on AD BBM ! alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Thank you so much for highlighting our recent work on #Parkinson synuclein SAA, DAT and MRI scans!

The Science of Parkinson's@scienceofpd.bsky.social · 6mo ago

Lot of a-syn seeding amplification assay status research today - new imaging report finds positive cases exhibit more dopaminergic deficit, whereas negative cases have more subcortical atrophy across both sporadic & genetic #Parkinsons movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Honored to share our work on #Parkinsons in the journal Movement Disorders! In sporadic and genetic PD, patients with synuclein SAA+ PD have more striatal DAT deficit relative to atrophy while those with synuclein SAA- PD have more striatal atrophy relative to DAT deficit. doi.org/10.1002/mds....

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neuropathology patterns https://www.biorxiv.org/content/10.64898/2025.12.30.697140v1

Official release 4.4.0 announced today 😌 Download: www.itksnap.org/download Graphical overview: www.itksnap.org/new440 Happy segmenting!

Hello Bluesky! Welcome to the official Penn ADRD Trajectories, Copathology, and Heterogeneity (PATCH) Lab account for the labs of Drs. Paul Yushkevich, Sandhitsu Das, and David Wolk at the University of Pennsylvania. Stay tuned for updates about our presentations at AAIC25!

youtu.be/gpQ19OPUm34 New integration with nnInteractive (github.com/MIC-DKFZ/nnI...) in ITK-SNAP 4.4.0-alpha2 (itksnap.org) lets you turn scribbles into 3D segmentations in seconds. All thanks to an amazing new model from Fabian Isensee and colleagues at @helmholtzimaging.bsky.social!

Demo of new Deep Learning Segmentation in ITK-SNAP 4.4

YouTube video by ITK-SNAP

youtu.be

Thrilled to see our team's work on the AInSights platform featured! Two years since we went live, and more exciting apps on the way. #AIinHealthcare #ClinicalDecisionSupport #HealthTech #AInSights #AIinHealthcare #ClinicalDecisionSupport #HealthTech www.hcinnovationgroup.com/imaging/arti...

Innovator Awards Winning Team: Penn Medicine’s PennAInsights

Automated solution extracts quantitative measures from existing imaging studies to improve diagnostic accuracy, reduce physician burden

hcinnovationgroup.com

ITK-SNAP (itksnap.org) is now on BlueSky!

🚨Paper alert Very happy to share our last work on #IntrinsicCapacity (IC) in dementia with Lewy bodies #DLB (n=154), compared AD (n=644) 👉DLB patients showed lower IC in all domains (locomotion, vitality, psychology, audition), requiring personalized interventions ! 🔓 shorturl.at/EfrCX

SUPER BOWL CHAMPIONS! THIS ONE’S FOR YOU PHILLY!

The mimicker of Alzheimer’s disease. Progressive amnestic syndrome with: 1) Hippocampal atrophy 2) Older age ~ 80+ 3) Negative AD biomarkers • Caution with amyloid positivity common with aging • Tau PET ideal but not covered • FDG-PET medial > lateral Temporal hypometabolism = supportive

Ian Kremer@wolverinebear.bsky.social · 2y ago

Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy (LATE) alz-journals.onlinelibrary.wiley.com/doi/full/10.... #dementia #neuroscience #NeuroSky #MedSky #neurology

Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy (LATE) alz-journals.onlinelibrary.wiley.com/doi/full/10.... #dementia #neuroscience #NeuroSky #MedSky #neurology

Thank you for the highlight and example case! With #LewyBody disease, posterior hypometabolism is often more prominent than atrophy. This could be related to changes in neuronal integrity of posterior networks by a-synuclein. academic.oup.com/brain/advance-article/doi/10.1093/brain/awae352/7906681

Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer and Lewy body disease

By assessing imaging and CSF biomarkers of amyloid, tau, α-synuclein and neurodegeneration, Duong et al. demonstrate that patients with mixed Alzheimer’s a

academic.oup.com

Ryan Townley@drtfromkc.bsky.social · 2y ago

This is excellent use of multimodal imaging that is available clinically. Both Alzheimer’s disease and Lewy body disease can involve posterior regions on FDG PET but LBD by itself doesn’t cause significant MRI atrophy. See also example of an MTA co-path case too academic.oup.com/brain/advanc...