Tessera

Anubhav Dhar @anubhavdhar.bsky.social · 4mo ago

Expansion microscopy is revolutionary but application to actin cytoskeleton has been challenging. Not anymore....we combine IntAct + U-ExM to get an unprecedented 3D nanoscale view of actin isoforms in expanded cells. Read the full revised paper here: plos.io/4vansgr

IntAct-U-ExM enables super-resolution imaging of isoform-specific actin networks across species

A previous study in PLOS Biology developed IntAct, a tool to study isoform-specific actin localization, dynamics and molecular interactions across species. In this Update Article, IntAct is coupled wi...

plos.io

Saravanan Palani@syncellbiolab.bsky.social · 4mo ago

Our new paper in @plosbiology.org introduces IntAct-U-ExM enabling isoform-specific imaging of actin at nanoscale across yeast, mammalian cells & primary neurons. Fabulous work spearheaded by @anubhavdhar.bsky.social along with an amazing team! #actin #U-ExM journals.plos.org/plosbiology/...

Nature Cell Biology @natcellbio.nature.com · 9mo ago

☕Shen, @zgelashvili.bsky.social and Niethammer developed an inner #NuclearMembrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer. bit.ly/3MZM6PF

Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction - Nature Cell Biology

Shen, Gelashvili and Niethammer developed an inner nuclear membrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer.

bit.ly

Anubhav Dhar @anubhavdhar.bsky.social · 10mo ago

Congratulations @syncellbiolab.bsky.social for this remarkable achievement and well-deserved recognition! 🎉🔥

EMBO@embo.org · 10mo ago

Twelve scientists from Chile, India, Nigeria, Singapore and Taiwan have been selected as new EMBO Global Investigators – Congratulations to the new cohort! 🧪 Read the press release: https://www.embo.org/press-releases/twelve-scientists-become-embo-global-investigators/ #funding #training

Raghav Agrawal @impactology@mastodon.social @impactology.bsky.social · last yr.

I don't think anybody has described the value of open source in the way Andrew Huang has, that essentially its to demystify the prestige around knowledge that comes with labels and preconceptions on how hard something is supposed to be www.youtube.com/watch?v=aFrT...

"One of the reasons I am so passionate about open source is that I worry that if people believe that technology is magic, then we find ourselves in a dangerous situation. We essentially become slaves to tech.

The people behind these companies, the people who make these rules, they’re also people. You’re a person, too. You have as much intelligence and capability as these other people have. They just haven’t revealed to you that you could do it. They’ve tried hard to hide it from you, and so you think it’s magic and you have to consent to these things. It’s very important for me to make sure that people who are using technology, if they ever feel trapped or if they feel lost or if they don’t feel that they have ownership of their life again, there’s a path they can walk. I really value free will

A lot of times at the end of the day part of the idea of seeing the world as a hacker and not seeing the labels on things and seeing things for the, that’s kind of the essence of free will. Like, you don’t tell me what this is. I see it. And a lot of the idea behind open source and sharing and sharing the idea of hacking is teaching people how to have that sense of free will and independence that ability to control their destiny"

@xipeng1.bsky.social · last yr.

I am very glad to see that our PolarSIM helps the leading scientists to observe richer dynamics and get more discovery! Congratulations to Zhixing team for this brand new palette of fluorescent dyes named after BeiDa! www.nature.com/articles/s41... @pku1898.bsky.social @zhixingchen2.bsky.social

Zhixing Chen@zhixingchen2.bsky.social · last yr.

Here come our new palette of fluorescent dyes. The BD dyes endeaves to balance glowy brightness, robust photostability, and biocompatibility. Let's boost 4D dynamic super-resolution imaging!!! www.nature.com/articles/s41... @spirochrome.com

Anubhav Dhar @anubhavdhar.bsky.social · last yr.

🚨 New preprint alert! We used IntAct + Ultrastructure Expansion microscopy to map actin isoforms in 3D🤯 Check out this gorgeous 3D volume of U2OS cells - revealing diverse filament networks including the elusive nuclear actin filaments! #cytoskeleton #microscopy #actin

Saravanan Palani@syncellbiolab.bsky.social · last yr.

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...

Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦@dudinlab.bsky.social · last yr.

You did it @syncellbiolab.bsky.social !! Amazing . Congrats to the Team and what gorgeous imaging ... Wow

Saravanan Palani@syncellbiolab.bsky.social · last yr.

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...

Mara Duncan @mcduncanlab.bsky.social · last yr.

Lovely work from Saravanan and colleagues, they insert the 13aa alfa tag into actin and then use an Alexa-nanobody to monitor actin in expansion microscopy in yeast and human cells. This is an excellent tool for actin research, and the general principle can be applied to a variety of other proteins.

Saravanan Palani@syncellbiolab.bsky.social · last yr.

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...

Sophie G Martin @sophiemartinlab.bsky.social · last yr.

Beautiful images 🤩

Saravanan Palani@syncellbiolab.bsky.social · last yr.

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...

Thiago Carvalho @cyrilpedia.bsky.social · 2y ago

1, 2, 3, 4. "Electronic lab notebooks, despite their popularity, are stored in proprietary formats, incur a recurrent cost, tend to become defunct over time, and have poor interoperability with each other" journals.plos.org/plosbiology/...

GitHub enables collaborative and reproducible laboratory research

GitHub, a platform widely used in software development, offers a robust framework for documenting all activities of laboratory research projects. This Community Page highlights the benefits of, and pr...

journals.plos.org