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Applied Systems Biology

@appsysbio.bsky.social

Leibniz Institute: Hans Knöll Institute Jena The research group Applied Systems Biology is concerned with the mathematical modeling and computer simulation of infection processes caused by human-pathogenic fungi.

30 Posts1159 Follower983 Folgt
Applied Systems Biology @appsysbio.bsky.social · 6d ago

📄 New collaborative publication in *Gut Microbes*! Congrats to co-first author Parastoo Akbarimoghaddam and our colleagues Zoltán Cseresnyés and Marc Thilo Figge. The study uses intestine-on-chip technology to investigate inflammation in ulcerative colitis. 🔗 doi.org/10.1080/1949...

Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis

Ulcerative colitis (UC) is characterized by disruptions of the gut microbiome and an exaggerated mucosal immune response in genetically susceptible individuals. Alterations in the composition of th...

doi.org

Applied Systems Biology @appsysbio.bsky.social · last mo.

📄 New collaboration publication! Congratulations to our colleagues Mounir Zerdani, Marc Thilo Figge, and Carl-Magnus Svensson on their contribution to a new study published in Colloids and Surfaces B: Biointerfaces. www.sciencedirect.com/science/arti... #Collaboration #Biomaterials #Publication

Ethanol-Driven Structural Transitions of Human Serum Albumin and Surface-Assisted 2D Network Formation on Ti-6Al-4V: A Kinetic-Morphological Map

Ti-6Al-4V, a widely used titanium alloy for load-bearing implants, is rapidly conditioned by adsorbed proteins in vivo. Protein conditioning layers on…

sciencedirect.com

Applied Systems Biology @appsysbio.bsky.social · 2mo ago

📄 New publication! Congratulations to Parastoo Akbarimoghaddam, co-first author of a new study in Small. onlinelibrary.wiley.com/doi/10.1002/... #Publication #Candida #Microbiome #OrganOnChip

Human Colitis‐on‐Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

This study establishes a human immunocompetent colitis-on-chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS-induced injury. It...

onlinelibrary.wiley.com

Applied Systems Biology @appsysbio.bsky.social · 5mo ago

📄 New paper published! Our colleague Zoltán Cseresnyés contributed to a new study in Advanced Healthcare Materials. 🔗 advanced.onlinelibrary.wiley.com/doi/full/10.... Congrats to all authors! 👏 #Publication #Research #Biomaterials

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide-I (BIM-I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles imp...

advanced.onlinelibrary.wiley.com

Applied Systems Biology @appsysbio.bsky.social · 5mo ago

📄 New paper accepted! Our colleague Carl-Magnus Svensson co-authored a study on engineering NRPS specificity to design new bioactive peptides. 🔗 pubs.rsc.org/en/Content/A... #NRPS #SyntheticBiology #Publication

Mapping the nonribosomal specificity code through promiscuity-guided A-domain engineering

Nonribosomal peptide synthetases (NRPSs) assemble bioactive peptides from various building blocks. The binding pocket residues governing building block specificity have allowed prediction of NRPS prod...

pubs.rsc.org

Applied Systems Biology @appsysbio.bsky.social · 6mo ago

📄 New review published! From Observation to Mechanistic Insight: Image-based Systems Biology of Human Pathogenic Fungi Image-based modeling reveals how fungal growth, immune evasion & host responses shape infection. 🔗 link.springer.com/article/10.1... #SystemsBiology #Fungi #Publication

From Observation to Mechanistic Insight: Image-based Systems Biology of Human Pathogenic Fungi - Current Clinical Microbiology Reports

Purpose of Review Human pathogenic fungi are increasingly recognized as major threats to human health, yet their complex biology and interactions with the host remain poorly understood. This review hi...

link.springer.com

Applied Systems Biology @appsysbio.bsky.social · 7mo ago

New paper accepted in Advanced Healthcare Materials! Our colleague Yann Bachelot co-authored a study on an iPSC-derived alveolar type II model for influenza A infection and drug testing. Congrats to all authors! 👏 advanced.onlinelibrary.wiley.com/doi/10.1002/... #Influenza #StemCells

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Patient-specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid inte...

advanced.onlinelibrary.wiley.com

Cláudia Vilhena@cvilhena.bsky.social · 9mo ago

🧵1/2- So so happy to share our very first publication from the #BIDlab! 🥳 🎉 🙏 A huge thanks to our super talented PhD student Miriana Battista and our amazing collaborators @appsysbio.bsky.social and Christoph Saffer for the work and support 👌 🙏 ⏩ pubs.acs.org/doi/full/10....

Mechanistic Insights into the Role of Extracellular Vesicles at the Bacterial–Host Interface

Bacterial and human cells produce extracellular vesicles (EVs) in response to diverse stimuli, e.g., toxins, oxidative stress, nutrient depletion, or high cell density. Here, we describe a cocultivation platform that allows recovery of mixed extracellular vesicles (mix-EVs) produced simultaneously by both cell types. We investigated interactions between Gram-positive and Gram-negative bacteria (Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, and Neisseria meningitidis) and human peripheral blood mononuclear cells (PBMCs). The production of the mix-EVs population decreased with higher bacterial concentrations. Exposing PBMCs to mix-EVs repressed the general transcriptomic signature, in contrast with a significant upregulation generated by single bacterial-EVs. However, mix-EVs-derived IL-1β upregulation was confirmed at the protein level. Inhibition experiments showed that IL-1β production involved TLR2 and TLR4 signaling, acting through IRAK-1 and TRAF6 related pathways. This approach provides a new platform for the study of EVs at the pathogen–host interface and presents mechanistic insights into the effect of EVs on an infected host.

pubs.acs.org

Applied Systems Biology @appsysbio.bsky.social · 10mo ago

New publication: "Selective activation of dynamics in kinetically frozen supramolecular polymer bottlebrush assemblies" #hki-Jena #BioimageAnalysisTools #SupramolecularPolymers #PolymerChemistry #Biomaterials #Nanotechnology #DrugDelivery #SoftMatter onlinelibrary.wiley.com/doi/10.1002/...

Selective Activation of Dynamics in Kinetically Frozen Supramolecular Polymer Bottlebrush Assemblies

Static at rest—dynamic on demand: Although supramolecular polymers are known for their dynamic nature, this study investigates the dynamics of amphiphilic assemblies based on polymer-modified benzene...

onlinelibrary.wiley.com

Applied Systems Biology @appsysbio.bsky.social · 11mo ago

🎉Exciting news from Applied Systems Biology @ HKI 🎉 We’re welcoming three new members: • Lennart Köhler — Technical Assistant • Behnaz Asiabanha — Master student and Assistant • Mariia Kolchanova — Master student and Assistant Great to have you on board! 🚀

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Applied Systems Biology @appsysbio.bsky.social · last yr.

📢 New article from our team! A model of neutrophil transendothelial migration at single-cell resolution has just been published in npj Systems Biology & Applications. 🔗 www.nature.com/articles/s41... #SystemsBiology #Publication#Neutrophils #ComputationalModeling #AppliedSystemsBiology #HKIJena

Complex-mediated evasion: modeling defense against antimicrobial peptides with application to human-pathogenic fungus Candida albicans - npj Systems Biology and Applications

npj Systems Biology and Applications - Complex-mediated evasion: modeling defense against antimicrobial peptides with application to human-pathogenic fungus Candida albicans

nature.com