Arnaud Machelart
@arnaudmachelart.bsky.social
Tries to understand the cellular response against Mtb and improve antiTB drugs delivery. @inserm @InstitutPasteurLille France
Can tuberculosis ever be beneficial to the host? Our new review explores this complex interplay between TB and coinfections. Congratulations to Joan Fine for her tremendous work! @ciilofficiel.bsky.social Unraveling the multifaceted impact of tuberculosis on coinfections www.cell.com/iscience/ful...
Unraveling the multifaceted impact of tuberculosis on coinfections
Health sciences; Medicine; Medical specialty; Medical microbiology
cell.com
📢 New publication in Scientific Reports by @natureportfolio.nature.com A new study led by Dr @arnaudmachelart.bsky.social reveals that the route of BCG vaccination critically shapes protection against bacterial pneumonia. @inserm.fr @pasteurlille.bsky.social @cnrs.fr @univlille.bsky.social
BCG immunisation through intranasal instillation protects mice against Streptococcus pneumoniae infection by enhancing alveolar macrophage activity - Scientific Reports
Scientific Reports - BCG immunisation through intranasal instillation protects mice against Streptococcus pneumoniae infection by enhancing alveolar macrophage activity
doi.org
Very happy to have participated in the “Health Effects of Vaccines: From Genomics to Policy” conference at Wellcome Connecting Science. Inspiring discussions on vaccines, host responses, genomics & public health. Congrats to Carine and Valentin for presenting their work!@ciilofficiel.bsky.social
Very happy to share our group’s second publication this month! In this work, we investigate the intrinsic anti-tuberculosis activity of polymeric β-cyclodextrin nanoparticles. Proud of the team’s efforts!
Centre d'Infection et d'Immunité de Lille@ciilofficiel.bsky.social · 9mo ago📢 A new pub in Int Journal of Pharmaceutics by Dr @arnaudmachelart.bsky.social team and Dr Ruxandra Gref team “Dual activity of low-molecular-weight polymeric β-cyclodextrins against tuberculosis" @inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social
🚀Thrilled to announce our latest publication in Journal of Controlled Release! Our team reveals a key property of antimicrobial nanovectors in the fight against infectious diseases. 🎉🔬 www.sciencedirect.com/science/arti...
Selective accumulation of nanoparticles in infected cells for targeted drug delivery
In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…
sciencedirect.com
📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team “Selective accumulation of nanoparticles in infected cells for targeted drug delivery” @inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social
Selective accumulation of nanoparticles in infected cells for targeted drug delivery
In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…
sciencedirect.com
Ravis d’accueillir le public pour les Journées Européennes du Patrimoine à l’Institut Pasteur de Lille ! 🧬 Notre équipe passionnée a présenté nos travaux sur la tuberculose. Merci à tous pour cette belle journée ! 👏
The @ciilofficiel.bsky.social team is at #IUIS2025 in Vienna! N. Mielcarek on BPZE1 pertussis vaccine, E. Hoffmann on ERA4TB drug testing, while @joanfine.bsky.social , I. Leleu, @vsencio.bsky.social & @arnaudmachelart.bsky.social are showcasing their work in poster sessions. #Immunology
🦠✨ Exciting science at #IUIS2025 in Vienna! Don’t miss posters on host–pathogen interactions by: 🔹 #338 Joan Fine 🔹 #342 Valentin Sencio 🔹 #347 Ines Leleu
Institut @pasteurlille.bsky.social teams joined the GRC #TB Drug Discovery and Dev. to present their latest work. With rising resistance and 1.5M deaths/year, better TB treatments are urgent. A week of fruitful talks & new collaborations! @hartkoorn-lab.bsky.social @arnaudmachelart.bsky.social
🚨 New review from our group! PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases. @ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social www.sciencedirect.com/science/arti...
Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers
Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…
sciencedirect.com
À l’Institut Pasteur de Lille, le Dr F. Real et son équipe (@ciilofficiel.bsky.social) montrent que le #VIH infecte les mégacaryocytes en réduisant IFITM3, une protéine antivirale. Ces cellules pourraient former un réservoir viral caché, empêchant de parvenir à une guérison du VIH ➡️ bit.ly/3FSMc8C
Excited to share our latest work on incorporating an antiviral molecule into delivery vectors to target pulmonary infections. 🍃🦠 www.sciencedirect.com/science/arti...
Pulmonary delivery of clofoctol-loaded nanoparticles inhibits SARS-CoV-2 replication and reduces pneumonia
Despite the progress made through vaccination campaigns and the use of antivirals, the need for more effective therapeutics to combat respiratory vira…
sciencedirect.com
🎤 Laurye Van Maele, chercheuse @inserm.fr au @ciilofficiel.bsky.social à l'Institut Pasteur de Lille, a joué le jeu de l’interview menée par une élève de 3e pour “Ta voix », le media jeune de @lavoixdunord.fr. Une belle rencontre intergénérationnelle autour de la #recherche 👉 bit.ly/4k3D2o1
Rencontre avec Laurye Van Maele, chercheuse à l’Institut Pasteur de Lille
Laurye Van Maele est chercheuse à l’Institut Pasteur de Lille. Melye, en stage che...
bit.ly
À l’Institut Pasteur de Lille, l’équipe du Dr François Trottein au @ciilofficiel.bsky.social montre qu’un microbiote intestinal déséquilibré chez les aînés aggrave le #COVID19. Probiotiques et prébiotiques pourraient améliorer la récupération 👉 pasteur-lille.fr/2025/04/16/m...
🚨New Pub🚨 #PulmonaryDelivery of clofoctol-loaded #Nanoparticles inhibits #SARSCoV2 replication and reduces pneumonia 💥 Study co-led by Drs Brodin, Trottein, Machelart ( @arnaudmachelart.bsky.social ) & Dr. R. Gref ( @ismolab.bsky.social ) | Institut des Sciences Moléculaires d'Orsay
Pulmonary delivery of clofoctol-loaded nanoparticles inhibits SARS-CoV-2 replication and reduces pneumonia
Despite the progress made through vaccination campaigns and the use of antivirals, the need for more effective therapeutics to combat respiratory vira…
sciencedirect.com
@arnaudmachelart.bsky.social , chercheur @inserm.fr Comment le #réchauffement #climatique favorise-t-il l’ #émergence des maladies tropicales ?
Réchauffement climatique et maladies tropicales : quels sont les liens ? - Arnaud Machelart - 10' #3
YouTube video by Pasteur Lille
youtu.be
@arnaudmachelart.bsky.social , chercheur @inserm.fr avec les doctorants Axelle Grandé et Amine Pauchet @univlille.bsky.social L’ #antibiorésistance, une bombe à retardement ?
L’antibiorésistance : quel danger pour l’environnement et notre santé ? - 10' de Prév'
YouTube video by Pasteur Lille
youtu.be
Réchauffement climatique et maladies infectieuses émergentes : (re)découvrez la conférence de nos chercheurs @inserm.fr @cnrs-hautsdefrance.bsky.social Dr A. Machelart @arnaudmachelart.bsky.social Dr M. Gissot. @gissotlab.bsky.social Dr S. Pied Dr S. Bontemps-Gallo @sebbontempsgallo.bsky.social
Conférences Envie de Savoir(s) dans le cadre des Printemps de la Prev' 2025
YouTube video by Pasteur Lille
youtube.com
Excited to introduce our (expanded) research group for 2025!
I am happy to have participated in the @anrs-mie.bsky.social Start Day. Young researchers have talent too!
24 mars, journée mondiale de lutte contre la #tuberculose ! À l’Institut Pasteur de Lille, Albert Calmette et Camille Guérin ont créé le BCG en 1921. Plus de 130 ans plus tard, nos chercheurs poursuivent cet héritage et continuent de lutter contre cette maladie mondiale 👉 bit.ly/4iFrsiS #EndTB.
#StandUpforScience 2025 – Because science is a common good. The @ciilofficiel.bsky.social was present alongside all colleagues on the @pasteurlille.bsky.social campus. #ScienceForAll @cnrs-hautsdefrance.bsky.social @inserm.fr @chulille.bsky.social @univlille.bsky.social
🔴 Women scientists at @ciilofficiel.bsky.social were joined by their colleagues from @pasteurlille.bsky.social, all dressed in red for the #Coquelicots initiative on #InternationalWomensDay Women in science exist! Let’s be visible: wear red & form a vast poppy field from the sky! 🌍🔬
📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣 Plus d'infos sur le mouvement 👉 standupforscience.fr #pasteurlille
Bravo Joan! @joanfine.bsky.social
CNRS Hauts-de-France@cnrs-hautsdefrance.bsky.social · 2y ago⏱ #MT180 | Hier se sont déroulées les présélections régionales Hauts-de-France ! Félicitations aux 12 doctorant.e.s sélectionné.e.s qui participeront à la finale régionale Ma Thèse en 180 Secondes le 19 mars prochain à Amiens ! 👏 ⤵️
#FluorescenceFriday The macrophage (nucleus in blue) protein Tirap (in red) is recruited to the Mycobacterium tuberculosis (in green)-containing vacuole. This recruitment is essential to enable bacterial replication. Belhaouane et al. PLoS Pathogens 2023
The Center for Infection and Immunity of Lille (CIIL) is now on Bluesky ! 📢 Follow us for updates on our latest research, collaborations, and breakthroughs in #infectious #diseases, #immunology, and #microbiology. 📍 Follow us here: @ciilofficiel.bsky.social
Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice: Cell Reports www.cell.com/cell-reports...
Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice
Silva Angulo et al. provide insights into mechanisms underlying respiratory bacterial susceptibility in the elderly. The authors demonstrate that the altered circadian expression of the nuclear recept...
cell.com
