Aurora Ruiz-Herrera
@aruizherrera.bsky.social
Professor @Universitat Autonoma Barcelona-Understanding how genomes organize, evolve & are transmitted to the offspring. #genomics #evolution #meiosis #3Dgenome #biodiversity Co-EiC @heredityjournal.bsky.social 👉https://webs.uab.cat/evolgenom/
🚨 New paper in Nature 🚨 Thrilled to be part of this fascinating collaborative study! 👉 SIRT7 regulates dosage compensation and safeguards the female X chromosome rdcu.be/fnEZQ A great example of how chromatin regulation continues to reveal unexpected layers of genome control!
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Nature - SIRT7 safeguards X-chromosome integrity and dosage balance with autosomes.
rdcu.be
🧬 Join the STRiVE kick-off conference (TiBE-STRiVE) July 8-10, 2026 near Porto! Registration & abstracts open: 🔹 Members: Feb 25-Apr 7 🔹 Non-members: Mar 16-Apr 7 Info: structuralvariantsstn.github.io/porto_about/ #Evolution #Genomics #Biology
📣 Call for Abstracts! Working on sex chromosomes? Join us at SMBE 2026 in Copenhagen (28 June–2 July). All taxa, systems, and approaches welcome! ⏰ Deadline: 3 Feb 2026 👉 smbe2026.org/abstracts/
💥Extremely proud of this team! 🎉 Congratulations to Laia Marin-Gual from @uab.cat on being awarded the Pere Alberch Prize by the @sesbe-org.bsky.social for the best doctoral thesis in evolutionary biology this year, and to Lucía Álvarez-Gonzalez for being runner‑up. Outstanding work! #sesebe2026
Toni Gabaldón@tonigabaldon.bsky.social · 7mo agoAs always, extremely high quality in the PhD thesis research awarded with the Pere Alberch prize by the @sesbe-org.bsky.social , excellent talk too by the awardee Laia Marin from @aruizherrera.bsky.social lab. Congratulations! #sesbe2026
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk. First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
nature.com
💥Huge shoutout to the @amarques.bsky.social team for an outstanding effort! So excited to have joined forces to decode how karyotype evolution connects with recombination 🧬 🔗 Preprint here: 👇 www.biorxiv.org/content/10.6...
A holocentric pangenome links karyotype evolution to meiotic recombination
Chromosomal fissions, fusions and whole-genome duplications propel genome evolution, yet their impact on meiotic recombination is obscured by the centromere constraint, since in monocentric species most large rearrangements are lethal. Holocentric organisms, which distribute kinetochore activity along the entire chromosome, overcome this barrier and therefore offer a unique window onto the interplay between karyotype change and crossover control. We assembled chromosome-scale genomes for 20 holocentric Rhynchospora species (including 56 haplotypes), representing all major clades of the genus, featuring satellite-based holocentromeres, and integrated single-gamete crossover maps, high-resolution meiotic synapsis cytology and Hi-C chromatin architecture. Breakpoint analysis shows that holocentromeric Tyba satellite arrays are recurrent hotspots for both chromosome fusions and fissions, contributing to the genus's extraordinary chromosome number variation from 2n = 4 to 36. Crossover landscapes group into two apparent modes: strongly distal-biased versus irregularly distributed, which is correlated with divergent patterns of synapsis elongation. Moreover, crossover number scales with chromosome count and meiotic axis length. In contrast, crossover density per megabase is inversely related to chromosome length and to chromatin-loop size. We propose that chromosome fissions create karyotypes with smaller chromosomes folded into shorter loops, thereby increasing the axial substrate accessible for double-strand break formation and elevating recombination frequency. Together, our results provide a structural link between large-scale structural chromosome evolution and meiotic recombination through coupled changes in chromosome number, size, loop geometry, and synapsis dynamics. ### Competing Interest Statement The authors have declared no competing interest.
biorxiv.org
André Marques@amarques.bsky.social · 7mo ago📢 Three new #bioRxiv preprints from our team on holocentric chromosomes. Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
💥2025 has been an extraordinary year for the team, full of challenges, but even more rewarding! None of this would have been possible without the incredible team of women who make everything happen. Young, driven, but above all, genuinely kind people 💜 Here’s to an even more exciting 2026! 🚀
🎯Excited to share our new collaborative paper in Mol Ecol - Beautifully lead by @marta-fb.bsky.social & @coreykirkland.bsky.social - Exploring the fascinating evolutionary story of the waterbuck, shaped by climate and unique chromosome changes onlinelibrary.wiley.com/doi/10.1111/...
Chromosome‐Level Genomics and Historical Museum Collections Reveal New Insights Into the Population Structure and Chromosome Evolution of Waterbuck
Advances in sequencing and chromosome-scale assembly have brought non-model animals into focus, deepening our understanding of genome and chromosome evolution. Here, we present the waterbuck (Kobus e...
onlinelibrary.wiley.com
🔬 Uncovering the mechanisms of sex chromosome dosage compensation in skinks! 🦎 🧬 Our latest collaborative study on how a lizard species with an extraordinary ability to change sexual phenotype maintains genomic balance. 👇 rdcu.be/eVjqW
Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype
rdcu.be
Excited to be part of the amazing team behind our upcoming symposium on Sex Evolution at #SMBE2026! 🔹 Daniel Jeffries 🔹 Paul Jay 🔹 @sphaeromeria.bsky.social 🔹 @astridboehne.bsky.social 🔹 @cbenvenuto.bsky.social Join us in Copenhagen for cutting-edge discussions on #sex #evolution
Society for Molecular Biology and Evolution@official-smbe.bsky.social · 8mo agoSMBE2026 Symposium 9 | New frontiers in sex evolution: evolutionary patterns and innovations 📨 Abstract submission smbe2026.org/abstracts 📋 Programme details smbe2026.org/programme #SMBE2026
Honored to be part of this exciting symposium at #SMBE2026! Huge thanks to Marie Raynaud, @duret-lbbe.bsky.social, and @susanjohnston.bsky.social for the invitation. Looking forward to sharing insights on recombination and evolution with such an amazing community. See you in Copenhagen!!!
Susan Johnston@susanjohnston.bsky.social · 8mo agoAre you a recombination researcher heading to #SMBE2026? Submit your abstract to our Symposium, organised by Marie Raynaud, Laurent Duret, and myself. We're excited to have Aurora Ruiz-Herrera from UAB Barcelona as our invited speaker. 🧬🦄🦠🌿🐝🐟🍄🪱 @aruizherrera.bsky.social @duret-lbbe.bsky.social
Looking for a cool image to represent the complexity of within-species genomic diversity? Look no further! Beautiful artwork by Binia De Cahsan!
🦣🧬🦣🤯💥We are pleased to share our new paper about ancient RNA expression profiles from the Woolly Mammoth, now published in Cell @cellpress.bsky.social www.cell.com/cell/fulltex... If you want to know more, read the 🧵 below:
The Genomic Kaleidoscope: On the Hidden Dimensions of Within-Species Genomic Diversity academic.oup.com/gbe/article/... 🧬🖥️🧪
👏 It really shows how powerful meetings can be for sparking ideas and collaborations —and when those turn into joint efforts like this, even greater! Thank you all for this fun adventure! @mbrasovives.bsky.social @diegoharta.bsky.social @jrotwitguez.bsky.social @theafrogers.bsky.social et al
Juan Antonio Rodríguez@jrotwitguez.bsky.social · 9mo agoSo, it all started after we organised a symposium at the @official-smbe.bsky.social meeting in 2024, in Puerto Vallarta, Mexico 🇲🇽. Together with all the speakers (all in the picture), we joined forces to write this Perspective for GBE, summarising the key ideas and results presented there. (3/n)
Brasó-Vives et al. publish a new Perspective in GBE, highlighting underexplored dimensions of genomic variation that contribute to phenotypic diversity beyond the DNA sequence, contributing to our understanding of genome evolution. 🔗 doi.org/10.1093/gbe/evaf204 #genome #evolution
🚨 New Paper Alert! Our latest perspective piece is out, and it’s one you won’t want to miss- 'The Genomic Kaleidoscope' academic.oup.com/gbe/article/... Co-lead by @mbrasovives.bsky.social @jrotwitguez.bsky.social & @diegoharta.bsky.social 📌 Check the full post here👇
Validate User
academic.oup.com
Juan Antonio Rodríguez@jrotwitguez.bsky.social · 9mo ago🔊New perspective piece out @genomebiolevol.bsky.social. "The Genomic Kaleidoscope: On the Hidden Dimensions of Within-Species Genomic Diversity" 💡🌀🌈 doi.org/10.1093/gbe/... Co-led with @mbrasovives.bsky.social and @diegoharta.bsky.social Check out our thread! 🧵👇 (1/n)
🎓 We have a new doctor in the house!!!!!!!! Last Friday, Cristina Marín García successfully defended her thesis with flying colours! Huge congratulations to her on this well-deserved achievement! 🏅 We’re lucky to have such a dedicated and inspiring team! 💫
Descubren cómo una proteína clave del ADN puede afectar la fertilidad masculina www.lavanguardia.com/launi/202510...
Descubren cómo una proteína clave del ADN puede afectar la fertilidad masculina
Lea este artículo en catalán Un equipo de la Universitat Autònoma de Barcelona ha identificado una nueva función de la proteína RAD21L, esencial para la fertilidad
lavanguardia.com
💥 Another fruitful collaboration! Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis 🐟#meiosis 👇 www.embopress.org/doi/full/10....
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
nature.com
The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
crick.ac.uk
Será interesante hacer de nuevo este gráfico dentro de 20, 30, 40 años. www.nature.com/articles/d41...
🏙️ Last week, #ERGA joined the @vertebrategenomes.bsky.social #VGP Conference in NYC, a great chance to connect with @ebpgenome.bsky.social projects and share progress on #FAIR genome assemblies & reporting under @biogeneurope.bsky.social www.erga-biodiversity.eu/post/erga-me... #genomes #conference
ERGA meets VGP in New York City
Last week, ERGA was present at the Vertebrate Genomes Project 2025 Conference, held at The Rockefeller University in New York City from September 30 and October 1. ERGA and VGP share a long-standing c...
erga-biodiversity.eu
📢 A la #bctUAB muntem un #GrupFocal amb l'alumnat de #doctorat i #màster per millorar en el suport que donem. 📅 Dimecres 15/10, d'11h a 12h Ens ajudeu a fer córrer la veu? @aruizherrera.bsky.social @ibb-uab.bsky.social @giq-bcn.bsky.social @crmatematica.bsky.social @aurahdezsabate.bsky.social
@bctuab.bsky.social · 10mo ago📢#UABer, estàs fent el #doctorat? O potser fas un #màster? Volem saber la teva opinió sobre l'ús de la #IA en la teva recerca i sobre l'accés a la #bibliografia de suport. Però ho volem fer d'una forma lliure i distesa. Ens deixes convidar-te a un cafè? ☕👇
We are very pleased to announce our joint meeting with the German @gfeev.bsky.social and the Dutch Developmental Biology Societies, which will take place in Potsdam from the 10-13th of March 2026. Registration is now open! www.uni-potsdam.de/en/gfe-meeti...
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
✨ It was great to attend the @vertebrategenomes.bsky.social Conference at @rockefeller.edu in New York City - Aiming to generate high-quality, near error-free reference genome assemblies for vertebrates to transform our understanding of biodiversity, evolution, and conservation 🐒🦒🐕🐗🦥🦉🐘
Vertebrate Genomes Project@vertebrategenomes.bsky.social · 10mo agoThis week, we hosted over 100 scientists at Rockefeller University in New York City for our 2025 in-person conference.
