📣 Three new CRN publications examine how immune regulation, gut microbiome changes, and mitochondrial proteotoxic stress may shape risk and vulnerability in #ParkinsonsDisease.

#TeamTuesday 🧠 CRN Team Doxakis is studying how co-pathologies may drive #Parkinsons disease progression. Their work examines how alpha-synuclein, tau, and TDP43 interactions may contribute to neurodegeneration and clinical heterogeneity. 🔗 bit.ly/45yo7gh

🔍 Parkinson’s often overlaps with other brain pathologies. 3 CRN teams are studying how protein interactions shape disease progression, helping define biological subtypes of #ParkinsonsDisease. 🔗 Learn more: bit.ly/4yPrCwA

📣 New neuroimmune research from CRN teams explores how cellular state, transposable element activity, and human organoid models can deepen understanding of #Parkinson’s disease biology.

This global analysis reinforces why population diversity matters in Parkinson’s genetics. Explore GP2’s interactive map to see its global cohort network, ancestry representation, and the collaborations helping advance more inclusive research: gp2.org/data-resourc...

Science X / Phys.org@sciencex.bsky.social · 3w ago

Nearly 100,000 people across 11 world regions show that Parkinson’s-linked variants in GBA1 and LRRK2 differ considerably by ancestry. Europe-focused testing may miss causes elsewhere. doi.org/hcbwfp

#TeamTuesday 🌱 CRN Team Khurana, one of our new PD Heterogeneity teams, is studying how pesticide exposures may shape #Parkinsons biology and clinical subtypes. Their work combines cohort data, stem-cell models, alpha-synuclein biomarkers, and AI tools. 🔗 bit.ly/4wVuHt4

📣 New genomics research from CRN teams examines how genetic risk variants, regulatory networks, and enhancer activity shape cell-type-specific #Parkinson’s disease biology.

New genomics research from several CRN teams explores how mitochondrial quality control, metabolic stress, and inflammatory signaling may contribute to #ParkinsonsDisease 🧠📈

Building research capacity starts with strong local and regional connections. A recent GP2-supported meeting & bioinformatics workshop in Bangkok brought together researchers across Asia to strengthen collaborations and build skills for locally led Parkinson’s genetics research. 🔗 bit.ly/3SYravv

Building Connections Across Asia: Supporting a Regional Meeting and the GP2 Bioinformatics Workshop in Bangkok

GP2 hosted a meeting and bioinformatics workshop in Bangkok for 80 clinicians and researchers, strengthening Asian Parkinson’s genetics research by fostering local collaborations, establishing patient cohorts, and training researchers in genetic data analysis.

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75% of #ParkinsonsDisease genetic data has historically come from individuals of European ancestry. A new massive study of 105K+ people from the Global Parkinson’s Genetics Program (GP2) published in @thelancet.com is changing that. Here is why it matters for the future of precision medicine: 👇

#TeamTuesday 🌱 CRN Team Kirkeby, one of our new PD Heterogeneity teams, is connecting the environmental exposome to #Parkinsons risk and pathology. Their work combines stem cell screening, exposomics, and Danish registry data to uncover toxicant-linked disease pathways. 🔗 bit.ly/4ym8wh6

📣 New genomics research from CRN teams explores lysosomal pathways, protein clearance, aggregation, and biomarker discovery in #ParkinsonsDisease. See how these studies are advancing understanding of the cellular systems that maintain protein and lipid homeostasis 🧠📈

📣 New genomics research from CRN teams highlights how cellular models, single-cell atlases, and analytical tools can reveal shared and subtype-specific biology across #ParkinsonsDisease 🧠📈

Dig into the numbers behind GP2’s latest data release. This release includes an expansion of harmonized environmental and lifestyle clinical data, such as pesticides, alcohol, and smoking, for researchers to further investigate gene-environment interactions. Learn more: bit.ly/444VBlY

#TeamTuesday 🌱 CRN Team Greenamyre is investigating how environmental toxicant exposures may trigger biological processes that drive neurodegeneration and contribute to #Parkinsons heterogeneity. Their work could help identify targets for mitigating post-exposure toxicity. 🔗 bit.ly/4fmkSOS

This summer, we’re highlighting recent CRN and GP2 manuscripts through a special series exploring themes across #Parkinsons research, including genomics, neuroimmune biology, circuitry and global genetics. 👉 Follow along for the latest findings.

This month’s Discover ASAP features CRN Team Rio’s Khaja Mohieddin Syed, PhD 🧪 He shares a single-cell atlas of familial #ParkinsonsDisease mutations designed to help researchers compare genetic effects, identify shared disease mechanisms, and generate new hypotheses. 📺 Watch: bit.ly/4eUd9HF

🎥 Check out a new CRN Cloud training video playlist to help researchers navigate the platform, explore available datasets, and begin analyzing shared #Parkinson’s disease omics data. The playlist includes a video on how to perform and share analyses using CRN Cloud datasets: bit.ly/4avLFp9

The 12th GP2 data release is now available. GP2 adds 21,156 additional genotyped participants and 25,046 additional whole-genome sequencing samples, with updates to data pipelines, clinical data including lifestyle and environmental factors, and genomic resources 🧪 bit.ly/444VBlY

#TeamTuesday 🌱 CRN Team Bronstein, one of our new PD Heterogeneity teams, is studying how environmental toxins and genetic factors may shape #Parkinsons progression. Their work uses stem cells and animal models to examine vulnerability to faster progression. 🔗 bit.ly/4waZHVM

A new #publication from CRN Team Alessi maps lysosomal protein composition across major brain cell types, revealing cell-type diversity and identifying SLC45A1 as a neuron-specific lysosomal protein tied to lysosomal dysfunction. 🔗 bit.ly/3QsxZEM

New #preprint from CRN Team Vila explores GABAergic cell clusters in the human midbrain. By identifying inhibitory neurons in the RMTg and RRF, the team lays the groundwork for studying their role in #neurodegenerative diseases. 🔗 Read the full preprint: bit.ly/4vbmGPx

In a new #preprint, CRN Team Harper reveals how LLOMe damages lysosomes. Using cryo-electron tomography, the team found that LLOMe forms amyloid structures that rupture lysosomal membranes, providing new insights into neurodegeneration and lysosomal storage disorders. 🔗: bit.ly/4oKzzy9

🧪 How do environmental exposures, like pesticides and chemicals, shape #Parkinsons risk, and point us toward new therapeutic strategies? Four CRN teams are studying how toxins interact with biology and genetics to drive disease, opening new paths for prevention and treatment. bit.ly/44wpUlv

What determines whether neurons resist or succumb to #ParkinsonsDisease? Discovery Fellows Jonathan Brenton, Kate Brynildsen, Raquel Garza Gomez, and Weiqiang Liu are uncovering how gene regulation, RNA processing, and epigenomic programs shape neuronal resilience ⬇️ 🔗 bit.ly/3PzdS7h

🧬 In a new blog, GP2 shares a three-year strategic roadmap, outlining the next phase that expands research beyond genetic discovery to better understand Parkinson’s disease through the study of genetic risk, biological mechanisms, disease subtypes, and environmental factors. 🔗 bit.ly/4eDthMd

Check out this new #preprint from CRN Team Strick exploring how cardiac-sympathetic activity helps regulate action restraint during reward- and loss-driven decision-making tasks. 🔗 Read the full preprint: bit.ly/4eKazUo

#TeamTuesday 🧫 CRN Team Ulusoy, one of our new Tool Generation teams, is developing labeled antibodies to better detect and measure mitochondrial and oxidative stress pathways in #Parkinsons disease, improving how researchers visualize disease biology. Follow the series👇 🔗 bit.ly/4nGXjD1

🔬 June’s #OpenScience Champion is Elena Coccia (CRN Team Vangheluwe)! Elena’s commitment to open science helped her recent preprint achieve compliance with ASAP’s Open Science Policy. She responded to each compliance report in under three weeks, helping the process move forward quickly.

We’re excited to welcome Jean-Marc Taymans, PhD, from the University of Lille as the June LRRK2 Central #webinar speaker. 👇 Reserve your spot using the link below. 📅 June 25, 2026 ⏰ 1:00 PM ET RSVP: bit.ly/4vJj0oQ