IgG4-related disease and other fibro-inflammatory conditions www.nature.com/articles/s41...
IgG4-related disease and other fibro-inflammatory conditions - Nature Reviews Rheumatology
IgG4-related disease is a fibro-inflammatory disorder with a complex pathogenesis. Herein the authors review the latest developments in IgG4-related disease clinical phenotyping, pathophysiology and m...
nature.com
Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation #Rheumsky #Immunosky
Non-Criteria Obstetric Antiphospholipid Syndrome: Myth or Reality? NC-OAPS: heterogeneous condition and ambiguously described in literature #APS #OAPS #Pregnancy #autoimmune
mdpi-res.com
Today is International Vasculitis Day! Take a look at some of our articles on vasculitis: Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis bit.ly/4kjASRj The new look of classification criteria for systemic vasculitis bit.ly/3GXJLlc
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis - Nature Reviews Rheumatology
This article presents the first Evidence-Based Guideline dedicated specifically to the diagnosis and management of eosinophilic granulomatosis with polyangiitis. The 16 statements and five overarching...
bit.ly
Behçet syndrome 🩸systemic #vasculitis, affects vessels of all calibers 🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum ⁉️ controversy: pathergy test or HLA-B*51 in diagnosis
sciencedirect.com
Arterial and venous thrombosis in systemic and monogenic vasculitis ⚠️ Be aware for early diagnosis‼️ 🧬 Genetic testing vital—variable penetrance! Early strokes hint at diagnosis. #vasculitis #thrombosis #monogenic #stroke #skin www.nature.com/articles/s41...
Arterial and venous thrombosis in systemic and monogenic vasculitis - Nature Reviews Rheumatology
Systemic vasculitis, including monogenic forms, is associated with an increased risk of arterial and venous thromboembolic events (AVTEs). This Review highlights the latest advances in the understandi...
nature.com
🚨2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis #Lupus #Nephritis #Guideline #Treatment #SLE assets.contentstack.io/v3/assets/bl...
assets.contentstack.io
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project 🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice 🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature academic.oup.com/rheumatology...
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project
ABSTRACTObjectives. The lack of uniform terminology and abbreviations for anti-synthetase syndrome has led to significant challenges in research and clinic
academic.oup.com
Remnant cholesterol predicts risk of recurrent thrombosis beyond LDL‑cholesterol in patients with antiphospholipid syndrome 🟠RC ➡️ increased risk of trombosis 🟠RC marker for thrombotic risk❓ 🟠potential target for therapeutic intervention. bmcmedicine.biomedcentral.com/counter/pdf/...
bmcmedicine.biomedcentral.com
EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation: 2024 update 🤰🏽👩🏽🍼 ard.eular.org/action/showP...
ard.eular.org
Consensus Recommendations for the Management of Neurosarcoidosis www.neurology.org/doi/10.1212/...
Consensus Recommendations for the Management of Neurosarcoidosis | Neurology Clinical Practice
Background and ObjectivesNeurosarcoidosis poses a diagnostic and management challenge due to its rarity, phenotypic variability, and lack of randomized controlled studies to guide treatment selection....
neurology.org
Recommendations for the use of DMARDs in pregnancy and reproductive health for patients with rheumatic disease: A scoping review acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Recommendations for the use of DMARDs in pregnancy and reproductive health for patients with rheumatic disease: A scoping review
Objective Autoimmune rheumatic diseases commonly affect individuals of childbearing age, with historically increased adverse pregnancy outcomes in this group. The advent of disease-modifying anti-rh...
acrjournals.onlinelibrary.wiley.com
To B or Not to B — the Role of B-Cell Depletion in Lupus Nephritis www.nejm.org/doi/full/10....
To B or Not to B — the Role of B-Cell Depletion in Lupus Nephritis | NEJM
B cells play a key role in the pathogenesis of lupus nephritis, yet in the Lupus Nephritis Assessment with Rituximab (LUNAR) trial, rituximab therapy did not improve clinical outcomes after 1 year ...
nejm.org
IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity 🔑involved in inflammatory and immune processes in SLE. 🔹IL-10 did not correlate with disease activity, organ in- volvement, or treatment response. www.mdpi.com/1422-0067/26...
mdpi.com
A proposed clinical tool to identify high-risk patients for #monogenic #lupus: a pilot study 💡<5 years 💡cosanguinity 💡Family #SLE 💡elevated ANA 💡pancytopenia 💡cutaneus lesions 💡Low C1q 💡Recurrent infections 💡Failure to thrive www.clinexprheumatol.org/abstract.asp...
A proposed clinical tool to identify high-risk patients for monogenic lupus: a pilot study
Paediatric Rheumatology; Authors: S.M. Al-Mayouf, D. Hadef, N. Aljaberi, N. Movahedi, A. Aleed, A. Almutairi, A. Asiri, S. Volpi, M. Gattorno, C.-Y. Wu, H. Tamim, A. Al-Saleem
clinexprheumatol.org
Therapeutic approaches for #SAPHO syndrome from the perspective of pathogenesis: a review of the literature 🔸Autoinflammatory 🔸cutaneous & osteoarticular 🔹ATB, tonsillectomy 🔹DMARDs 🔹Bisphosphonates www.frontiersin.org/journals/imm...
frontiersin.org
British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024 👇🏼👀 academic.oup.com/bjd/article/...
British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of Behçets. The document aims to offer a
academic.oup.com
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus 1️⃣ Articular/mucocutaneous ➡️better survival 2️⃣Severe phenotype with renal involvement ➡️ poor prognosis 3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies rmdopen.bmj.com/content/11/2...
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus
Objective Systemic lupus erythematosus (SLE), a systemic autoimmune disease with heterogeneous severity, poses a challenge in classifying patients due to its dynamic phenotype. We therefore aimed to i...
rmdopen.bmj.com
Urine Protein Tests in Systemic Lupus Erythematosus: What Do They Mean? #SLE #Lupus #LN www.jrheum.org/content/jrhe...
jrheum.org
Autoinflammatory Diseases: A Revision www.jrheum.org/content/51/9...
Autoinflammatory Diseases: A Review
Autoinflammatory disease (AID) is a vast spectrum of disorders characterized by recurrent attacks of sterile inflammation. Since the first cloning of the familial Mediterranean fever gene in 1997, the...
jrheum.org
Antiphospholipid syndrome in pregnancy: a comprehensive literature review 🤍 bmcpregnancychildbirth.biomedcentral.com/articles/10....
Antiphospholipid syndrome in pregnancy: a comprehensive literature review - BMC Pregnancy and Childbirth
Background Antiphospholipid syndrome (APS) is an autoimmune disorder associated with thrombotic events and adverse obstetric outcomes, particularly in its obstetric form (OAPS). Affecting approximatel...
bmcpregnancychildbirth.biomedcentral.com
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis 📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper www.nejm.org/doi/full/10....
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis | NEJM
Giant-cell arteritis is a systemic vasculitis with limited treatment options. The efficacy and safety of upadacitinib — a selective Janus kinase (JAK) inhibitor that blocks the signaling of several...
nejm.org
Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis 🔸MMF in dcSSc and show benefit especially in early-stage disease. 🔸High-risk ab for lung fibrosis ➡️ suitable for MMF treatment. acrjournals.onlinelibrary.wiley.com/doi/full/10....
Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis
Objectives The RESOLVE-1 trial of lenabasum in diffuse cutaneous systemic sclerosis (dcSSc) allowed background immunosuppressive therapy (IST) at the discretion of individual investigators, and no s...
acrjournals.onlinelibrary.wiley.com
Thoracic Manifestations of ANCA-associated Vasculitis: Review of the 2022 American College of Rheumatology–European Alliance of Associations of Rheumatology Classification Criteria #ANCA #Vasculitis pubs.rsna.org/doi/10.1148/...
Thoracic Manifestations of ANCA-associated Vasculitis: Review of the 2022 American College of Rheumatology–European Alliance of Associations of Rheumatology Cla...
The American College of Rheumatology–European Alliance of Associations of Rheumatology classification criteria were released in 2022 to increase the likelihood of antineutrophil cytoplasmic autoant...
pubs.rsna.org
2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis
The accepted version of this article was posted prematurely on March 24, 2025. The final version of record will be made fully available at a later date.
acrjournals.onlinelibrary.wiley.com
Familial Mediterranean Fever; Recent Advances, Future Prospectives 🤩 Wonderful review of #FMF, it’s a must! www.mdpi.com/2075-4418/15...
mdpi.com
Systemic lupus erythematosus: one year in review 2025 🔸New insights into immune dysregulation 🔸Emerging treatments: Promising therapies 🔸Real-world impact: Anifrolumab and belimumab www.clinexprheumatol.org/article.asp?...
clinexprheumatol.org
Pentose phosphate pathway metabolite restores T cell balance in SLE #SLE #LUPUS www.nature.com/articles/s41...
Pentose phosphate pathway metabolite restores T cell balance in SLE - Nature Reviews Rheumatology
Gluconolactone promotes Treg cell function and might have potential for treating skin lesions in systemic lupus erythematosus.
nature.com
Even low levels of anticardiolipin antibodies are associated with pregnancy-related complications: A monocentric cohort study 🧵 #APS #Pregnancy #Antibodies obgyn.onlinelibrary.wiley.com/doi/full/10....
<em>Acta Obstetricia et Gynecologica Scandinavica</em> | NFOG Women's Health Journal | Wiley Online Library
The impact of low aCL levels on the course of gestation remains unclear. Our study confirmed a higher incidence of pregnancy-related complications in low-titer aCL pregnancies, but only in the case o...
obgyn.onlinelibrary.wiley.com
Just Autoimmunity? The Role of the Innate Immune Response in Lupus #Lupus #SLE #Autoimmunity journals.lww.com/jclinrheum/f...
Just Autoimmunity? The Role of the Innate Immune Response... : JCR: Journal of Clinical Rheumatology
ith conventional or biologic drugs. However, in some cases, the clinical response is limited and frequently takes a high toll of toxicity in patients. The last 2 decades have brought up novel discover...
journals.lww.com