Just published in JOSS: 'TarGene: A Nextflow pipeline for the estimation of genetic effects on human traits via semi-parametric methods.' https://doi.org/10.21105/joss.09603

📣 In case you missed it - we've opened expressions of interest for our Norwich #SingleCell and #Spatial symposium this summer, including speakers @tatsuyanobori.bsky.social, @arnausebe.bsky.social, and @avakhamseh.bsky.social! 👏 Find out more below 👇 💻🧬

Norwich Single-Cell and Spatial Symposium 2026

Bringing together the international single-cell and spatial community for a two-day discussion across model and non-model systems.

buff.ly

New📢 Between molecular and human traits is a yawning gap: What do molecules do to single cells? We tested *all* human or mouse miRNA mimics for their cell morphological effects on 5 cell lines. To do so, we applied Cell Painting at the *single cell* level (100,000+ images). doi.org/10.1101/2025...

Systematic morphological profiling of human and mouse miRNAs in 24M single cells

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression whose contributions to cell biology remain underexplored. Here, we used Cell Painting to quantify the morphological effect of ...

doi.org

Interested in ME/CFS research? Want to do a PhD with @aryback.bsky.social, @avakhamseh.bsky.social, @sjoerdvbeentjes.bsky.social & @cgatist.bsky.social? Then apply for a *funded* Future Medicine PhD Fellowship. See: www.findaphd.com/phds/project... Please contact us to discuss before applying.

Personalised blood-based biomarkers for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) symptom severity at University of Edinburgh on FindAPhD.com

PhD Project - Personalised blood-based biomarkers for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) symptom severity at University of Edinburgh, listed on FindAPhD.com

findaphd.com

We integrate population genetics, functional genomics & targeted ML to uncover 100s of TF-linked epistatic interactions across 768 traits in UK Biobank. Epistasis, informed by mechanism, empowered by robust stat/ML, is detectable & widespread. doi.org/10.1101/2025... (1/n)

New course “EMBO Causality in Biomedicine”: We have organised the first EMBO course in *causal* stats/ML methods for quantitative biomedicine. @sjoerdvbeentjes.bsky.social @nimahejazi.org @pablormier.bsky.social @DariaSokolova @CarolineUhler Very much looking forward to teaching and discussing!

EMBL-EBI Training@training.ebi.embl.org · 12mo ago

New course announced! We're thrilled to be hosting the @embo.org Practical Course 'Causality in biomedicine: going beyond associations' from 4 – 9 October 2026. Register your interest and be the first to hear when the course opens for applications: www.ebi.ac.uk/training/eve...

📢 Now published: www.embopress.org/doi/full/10..... Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences. bsky.app/profile/cgat...

Replicated blood-based biomarkers for myalgic encephalomyelitis not explicable by inactivity | EMBO Molecular Medicine

imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different,...

embopress.org

Chris Ponting@cgatist.bsky.social · 2y ago

116 blood traits are significantly different – on average – between people with #MEcfs and healthy controls, *both* in females, and in males. This keeps alive the future ambition of a blood-based biomarker panel for accurate #MEcfs diagnosis www.medrxiv.org/content/10.1...

📢Now published! Know that clustering cells in reduced dimensions is problematic? Want to identify cell subtypes or states *without* clustering? Then check out Stator which finely resolves states & subtypes even among apparently homogeneous cells Thread www.embopress.org/doi/full/10....

High order expression dependencies finely resolve cryptic states and subtypes in single cell data | Molecular Systems Biology

imageimageStator assigns multiple states and (sub)types to a single cell using coordinated gene expression and/or non-expression in a data-driven manner. Its application of structure learning has incr...

embopress.org

I am STOKED that myself and @avakhamseh.bsky.social are looking for a joint EastBIO PhD candidate across @uniofaberdeen.bsky.social and @uoe-sps.bsky.social to develop cutting-edge statistical models at the interface of single cell genomics and quantitative genetics: shorturl.at/vQo0P pls reskeet!

EASTBIO: Mapping DNA variants to cell states in health and disease at University of Aberdeen on FindAPhD.com

PhD Project - EASTBIO: Mapping DNA variants to cell states in health and disease at University of Aberdeen , listed on FindAPhD.com

shorturl.at