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Chris Ponting

@cgatist.bsky.social

Disease genomics & molecular mechanisms; ME/cfs: http://decodeme.org.uk, SequenceME @ Edinburgh University. Views - my own. He/him.

108 Posts3576 Follower279 Folgt
Eric Topol@erictopol.bsky.social · 2h ago

Severe Covid leads to persistent viral reactivation, with >10 different viruses noted in the first 40 days after hospital admission. Long Covid was specifically associated with reactivation of latent Anelloviridae virus @nature.com www.nature.com/articles/s41...

Virus reactivation in acute and long COVID-19 - Nature

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

nature.com

Dr Rae Duncan@sunny-rae1.bsky.social · 6d ago

1/Introducing the International Society of Long COVID and Post-Acute Infection Syndromes (ISLC-PAIS) The COVID-19 Pandemic had highlighted the urgent need for a Paradigm shift in the way we approach post-acute infection syndromes. ISLC-PAIS aims to answer this call to action islc-pais.com/about

About · ISLC–PAIS

Mission, history and the five values that guide the International Society for Long COVID & Post-Acute Infection Syndromes.

islc-pais.com

Jeff Groh@jeffgroh.bsky.social · last wk.

Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...

Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS

In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...

pnas.org

Greg Jenner (Historian)@gregjenner.bsky.social · last wk.

Please sign this UK government petition to compel AI companies to reveal whose books they used to train their data petition.parliament.uk/petitions/76...

Petition: Protect creators' rights: require AI firms to disclose training data

We ask the Government to introduce a statutory duty requiring AI developers to disclose the copyrighted works used to train generative AI in enough detail for creators to identify use of their work, e...

petition.parliament.uk

Chris Ponting@cgatist.bsky.social · last wk.

“Physical inactivity cannot solely explain the lower exercise capacity and skeletal muscle adaptations in long COVID and ME/CFS patients” www.nature.com/articles/s41...

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest - Nature Communications

Low aerobic capacity in patients with long COVID and ME/CFS is often attributed to physical inactivity. The authors show that long COVID and ME/CFS patients have distinct skeletal muscle changes that ...

nature.com

Prof. Stefan Rahmstorf@rahmstorf.bsky.social · 2w ago

Holiday in the climate emergency. No that’s not AI or edited, just a snapshot I just took with my phone on Lacanau beach in France. What future will this boy grow up in? It is in our hands, but time is running out.

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ME/CFS Science@mecfsscience.org · 2w ago

1) We wrote a new article on cell and tissue analysis using genetic data. For ME/CFS, the results strongly point to neurons. One of the top hits is the medium spiny neuron, located in a region deep inside the brain called the striatum.

Cell and tissue enrichment in ME/CFS - ME/CFS Science

By matching DNA results with gene expression databases researchers can determine the tissues and cellContinue readingCell and tissue enrichment in ME/CFS

mecfsscience.org

Marc Coutanche@marccoutanche.bsky.social · 3w ago

Starting September, international students will be limited to four years of study. With most PhD programs lasting 5 or 6 years, this is a huge blow - to the International students themselves and to our ability to recruit the best students we can. This is not how the U.S. remains competitive.

Trump administration tightens visa rules for foreign students

Students will need federal permission to stay longer than four years in the US and universities will lose the power to extend visas.

bbc.com

Prof Naomi Fulop@profnaomifulop.bsky.social · 3w ago

Very pleased to give bereaved families’ statement following publication today of #covidinquiry report into procurement. Lays bare the corruption & cronyism that led to avoidable deaths, incl my mum’s, & wasted billions of public £. @cbffjuk.bsky.social www.theguardian.com/uk-news/2026...

‘Catastrophic failure’: UK Covid families welcome inquiry findings on PPE

Campaigners feel vindicated by some of report’s conclusions but are unconvinced by its verdict on VIP lane

theguardian.com

Royal Academy of Engineering@raeng.org.uk · 4w ago

The 2026 MacRobert Award winners have been announced - @nanoporetech.com have been awarded the UK's longest and most prestigious prize for engineering innovation. Their pioneering DNA sequencing technology could transform global health. Find out why: https://raeng.org.uk/macrobert-winner-2026

Rapid DNA sequencing breakthrough wins the 2026 MacRobert Award

Oxford Nanopore Technologies has won the UK's most prestigious prize for engineering innovation

raeng.org.uk

ME/CFS Science@mecfsscience.org · last mo.

1) An overview of positive developments in ME/CFS research 👇 The European Union awarded €7.5 to a ME/CFS consortium that will conduct multi-omics and test biomarkers in hundreds of patients. It will connect and harmonize five biobanks across the continent. bsky.app/profile/mecf...

ME/CFS Science@mecfsscience.org · last mo.

1) 🇪🇺 Good news! The European Union has awarded € 7.5 million for a big ME/CFS consortium that will study biological mechanisms in hundreds of patients. This is a major milestone for ME/CFS research in Europe.

Andrew Wehrman@profwehrman.bsky.social · last mo.

Today is the 250th anniversary of Boston’s mass inoculation against smallpox on July 3, 1776. The city was effectively closed to commerce from July through September 1776. The mass immunization effort was cheered as evidence of true independence. Here's how I described it in my book:

While John Adams and fifty-five men in Philadelphia debated a resolution on independence and the final wording of the Declaration of Independence, the people of Boston declared their own independence from smallpox. The measures taken in both cities provided hope that America would not only be a republic free of a king but also a country free from disease. On July 3, 1776, a day after independence was declared in Philadelphia, the Massachusetts General Court voted to allow inoculation. Despite the dangers of infection, the people of Boston and the surrounding areas cheered the news. Ezekiel Price, a court official and insurance broker, declared “Liberty is given for to inoculate for the small-pox; many begin upon it this afternoon.” Hannah Winthrop described the scene: “Boston has given up its Fears of an invasion & is busily employd in Communicating the Infection. Straw Beds & Cribs are daily Carted into the Town.” She wrote that “Men Women & children eagerly crowding to inoculate is I think as modish as running away from the Troops of a barbarous George was the last year.” Dr. James Warren wrote to John Adams that the “rage for inoculation” had “whirled me into its vortex.…” Warren and his wife Mercy Otis joined Abigail Adams and her four children who had been invited to be inoculated at Abigail’s uncle’s house in Boston along with Abigail’s sisters Elizabeth Cranch and Mary Shaw and their families. Even though Boston was teeming with the sick, the prospect that the city could conquer smallpox made it "a scene delightful indeed." Cotton Tufts was satisfied that he could now "take my leave of Earth, satisfied that the Day of American Redemption was at Hand."
Wendy Bickmore@wbickmor.bsky.social · last mo.

Very honoured that the lab has been selected as the first UK Center for Excellence by the CdLS foundation www.cdlsusa.org/centers-for-.... We aim to advance knowledge about this genetic condition and to explore similarities to other rare genetic disorders that affect gene regulation.

Centers for Excellence | CdLS Foundation

Our expanded Centers of Excellence network is here — 8 designated centers, 10+ lead investigators, and the people turning lived experience into discovery. See who's part of Mission Possible.

cdlsusa.org

Tahir Ali, Ph.D.@tahirali-biomics.bsky.social · last mo.

#SMBE2026 — A wake‑up call Moisés Expósito‑Alonso showed the hard truth: genetic diversity is collapsing, and global policy is still treating it as optional. Species have already lost >10% of their genetic variation — the very engine of adaptation and survival.

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Jason Tan@yjtan.bsky.social · last mo.

Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...

Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers

Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...

biorxiv.org

Alan Lester@alanlester.bsky.social · last mo.

With hardly any media coverage one of Britain’s few world-leading sectors is, right now, being decimated. The university funding model does not work and anti-immigrant hysteria has deprived the country of the means by which we met the shortfall: international students.

Margot Finn@eicathomefinn.bsky.social · last mo.

A grim day in a grim week in a grim month for UK higher education, with Dundee, Exeter and Hertfordshire all making major announcements of planned redundancies. Shrinkage of the research & teaching base by the invisible hand's visible fist is not an 'us' or 'them', SHAPE or STEM phenomenon. 1/2

Photo of an open hand, with part of 4 fingers showing.
Chris Ponting@cgatist.bsky.social · 2mo ago

Final #DecodeME analysis has been stalled since 22 April when UK Biobank removed access to its compute for all users. Yesterday, they wrote again but without a timetable for re-opening, just saying that this timetable would be available in June. We will complete our analyses asap thereafter. #MEcfs