The Batlle Lab
@batllelab.bsky.social
We work on minimal residual disease and metastasis by colorectal cancer from the perspective of cancer stem cells and their interaction with the tumor microenvironment. @IRBBarcelona,bsky.social
A pleasure to be part of it
EACR - European Association for Cancer Research@helloeacr.bsky.social · 2mo agoLast week we wrapped up an incredible EACR Annual Congress! Over 2400 participants joined us for 4 days of cutting-edge cancer research, inspiring talks and global collaboration in Budapest. #EACR2026 Sign up here for updates about EACR 2027 in Bilbao… 👀 eacr.us5.list-manage.com/subscribe?u=...
Already excited for next year's congress? Make sure to save the date in your calendars, and sign up for #EACR2027 updates! eepurl.com/dvcaQf
📌 Join us in our plenary #seminar this week, with Hugo Snippert, from @themaximacenter.bsky.social. 🤝 Host: @batllelab.bsky.social Register here ➡️ https://shorturl.at/pWcSN #IRBBarcelona #CancerResearch
Thrilled and grateful 🙏 🌟We have been awarded a new ERC Adv Grant to launch #PlasticCRC, a project that will explore how tumour cell plasticity 🧬🔄 drives adaptation and resistance in metastatic CRC. 🙌🏼Many thanks to everyone in the lab and collaborators. ➡️Looking forward to the science ahead!
European Research Council (ERC)@erc.europa.eu · last mo.The results of the Advanced Grants 2025 are here! Out of 3,329 applicants, 319 leading researchers have been awarded an ERC Advanced Grant. Congratulations to all! 🎉 Curious to know more ? 👉 buff.ly/uiU9x5K #ERCAdG #FrontierResearch
🙏Thank you to Ràdio Barcelona for the Toresky Award 🎙️ 🏆Although it recognizes a “personality,” the lab’s discoveries are the result of my team’s dedication and passion 🥼PhDs, postdocs, & senior members work relentlessly to make possible the breakthroughs being recognized today 🙌 ✨Huge thanks to all
At the Tumor Heterogeneity, Plasticity & Therapy conference in Leuven! 🌟🇧🇪 Huge thanks to the organizers for the invitation. 🙌 Tumour heterogeneity and plasticity are critical areas that are reshaping how we understand therapy resistance and tumour evolution.🔬 www.vibconferences.be/events/tumor...
Tumor Heterogeneity, Plasticity and Therapy (3rd edition)
10-12 December 2025, Leuven, Belgium
vibconferences.be
Yesterday in Valencia Dr. @nlbigas.bsky.social received the 2025 Premio Rei Jaume I in Biomedical Research. Her work on how cancer mutations arise and evolve has earned major recognition! Congratulations, Núria! 🙌 #ReiJaumeI #CancerResearch @cerca.cat @icreacommunity.bsky.social @bbglab.bsky.social
PODCAST: Conversaciones del Premio Nobel Producida por Nobel Prize Outreach y la @fundacionareces.bsky.social, los podcast de la serie "Conversaciones del Premio Nobel " proponen acercar a la sociedad española los logros de estos científicos y sus historias personales.
1/17 🧵 🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇 ➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC). Very proud of the team and efforts behind it. www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
nature.com
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision #Bluetorial below👇🏼 #KRAS #Plasticity #ColorectalCancer
The Batlle Lab@batllelab.bsky.social · 10mo ago🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
⏳Countdown to the 14th #CNAGSymposium! 🗣️Don’t miss Dr. Eduard Batlle from @irbbarcelona.org (@icreacommunity.bsky.social), sharing his insights on “Plasticity, therapy resistance, and immune evasion in metastatic colorectal cancer” 🗓️Dec 16, BCN 📎 www.cnag.eu/events/14th-... @batllelab.bsky.social
🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
🔬 #ColorectalCancer evades #immunotherapy using a dual barrier: A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms. 📰 @natgenet.nature.com ➡️ bit.ly/49BJaC0 #IRBScience @batllelab.bsky.social 🧪
1/17 🧵 🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇 ➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC). Very proud of the team and efforts behind it. www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
nature.com
Could understanding how #cancer cells talk to their neighbours help stop the disease? Johanna Joyce, a regular at #VIBConf, will uncover these new ways to predict, prevent, and treat cancer. Join #THPT25 before 26 Nov and decode the therapies that outsmart cancer: vibbio.tech/3Le9oAr #tumorbiology
At the Oncode Annual Conference 2025. Fantastic Meeting. Thanks for the invite. Catching up with many colleagues and friends. www.oncodeinstitute.nl/events/oncod...
Oncode Annual Conference 2025 | Oncode Institute
Registration is closed!There are roadworks, so the public transport route is different from previous years. For up-to-date information, please use Reisplanner | GVB or Plan je reis met het OV en deelv...
oncodeinstitute.nl
Registration for Cancer Cell Plasticity closes on Monday 03 November! Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels: eacr.org/conference/c...
🙌🏼 What a fantastic meeting this was! Congrats to everyone who contributed! #EESOrgan @events.embo.org 🔝 A huge thank you to the organizers for the invitation, and for putting together such a memorable conference. 📸 A remarkable aspect was seeing together five generations of Clevers’ Lab!!
EMBL Events@events.embl.org · 10mo agoWelcome to the first day of the EMBO | EMBL Symposium 'Organoids: modelling organ development and disease in 3D'! What better way to start the conference than with a keynote lecture by Paola Arlotta? #EESOrgan 🦠 🧬
📣 Last chance to register for the EACR virtual conference on Cancer Cell Plasticity You’ll gain new insights into fundamental mechanisms controlling cancer cell plasticity as well as innovative approaches to target them ➡️https://eacr.org/conference/cancercellplasticity2025 @helloeacr.bsky.social
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision #Bluetorial below👇🏼 #KRAS #Plasticity #ColorectalCancer
The Batlle Lab@batllelab.bsky.social · 10mo ago🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
➡️ This important video was missing from yesterday’s #Bluetorial. CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth. Centonze et al., in #CancerDiscovery #AACR
The Batlle Lab@batllelab.bsky.social · 10mo ago🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
➡️ This important video was missing from yesterday’s #Bluetorial. CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth. Centonze et al., in #CancerDiscovery #AACR
The Batlle Lab@batllelab.bsky.social · 10mo ago🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
🏆 El lliurament dels Premis Dia del Biòleg 2025 de @biolegscat.bsky.social tindrà lloc demà 25 d'abril a les 16:30 h al COACB. Enhorabona a tots els guardonats! Entre ells, @batllelab.bsky.social, de l'#IRBBarcelona! 🔴 Segueix la cerimònia en directe aquí: https://f.mtr.cool/egtmfleqvu
Estic molt agraït pel reconeixement rebut. Em sap greu no haver pogut assistir a l’acte de lliurament del premi i a la celebració del Dia del Biòleg. Afortunadament, l’equip hi ha pogut ser present en representació.
Un placer y un honor dar la 28a Lección Conmemorativa Teófilo Hernando. Amigos, colaboradores y científicos a los que respeto y admiro entre los ponentes anteriores.
It’s a pleasure to present our work at CRG’s annual symposium. Many good friends and colleagues around.
Centre de Regulació Genòmica (CRG)@crg.eu · last yr.It's a beautiful spring day in Barcelona. Sunshine welcoming all our guests for the first day of the CRG's annual symposium! This year's theme is all about the mechanisms of gene expression.
