Baylink Lab

@baylinklab.bsky.social

🦠Enthusiastic microthanatologists (i.e. the study of how to kill microbes) & lovers of redox biology and bacterial chemotaxis🧫 Washington State University - Esch LEAD Professor - Inclusion of Rural Individuals in Science (IRIS) www.baylink-lab.com

Lots of great vector-borne disease research in our department here at #WSU in Pullman, WA. Come join the team! Borrelia, Anaplasma, and more! Veterinary Microbiology & Pathology Dept within the College of Veterinary Medicine. #lymedisease #microsky #idsky 🧪🦠🧫

Dana Shaw@shawlab.bsky.social · 6mo ago

My department at Washington State University is recruiting an Assistant or Associate Professor in vector-borne disease 🕷️🦟🦠 Full job description is linked below. Come join us on the Palouse!

A big congratulations to future #IDsky physician-scientist Bruce Redden for his research presentation award at this year's ABRCMS. Lots of time and practice went into that presentation! Such a great meeting for the next generation of researchers to network & share discoveries! 🦠🧪 #medsky #medsky

Photo of Bruce holding his award.

ASM NW was wonderful this year! In addition to the great science, this trainee-focused meeting plays such an important role in providing the next generation of scientists, microbiologists, and clinicians an opportunity to learn, network, and share their own research. 🧪🦠

Photo of the Baylink lab group that attended ASMNW.

🚨 Postdoctoral Position 🚨 Investigate molecular mechanisms of protein homeostasis in Salmonella during infection! Strong background in biochemistry/molecular biology encouraged. 📩 Send CV, publications, and statement to Eduardo A. Groisman at Yale: eduardo.groisman@yale.edu 🧪 #microsky 🦠 #BLAST

Wonderful how Alphafold has opened up protein structure prediction to non-experts but you still have to feed it correct information (like oligomeric state!). A small test case shows AF3 makes excellent guesses on natural variants but inaccuracies occur from dubious user inputs. #microsky #IDsky 🧪🦠

Comparisons of crystal structure and AlphaFold 3 models of KatASS1. (A) Overlay of crystal structure KatASS1 (two chains, yellow) and crystal structures of KatA26659 (light gray, four chains). Variant sites are noted in pink. (B–E) Poses of variant residues within KatASS1, as indicated. KatASS1 crystal structure chains are shown in yellow and KatA26995 crystal structure chains in light gray. Green mesh is mFo-DFc omit map electron density at 3.5 σ averaged over the two non-crystallographic symmetry (NCS) chains, and dark blue mesh is 2mFo-DFc NCS-averaged electron density at 1.0 σ of the final model. (F) Overlay of the KatASS1 crystal structure (yellow) with three AlphaFold 3 models (light blue, blue, and dark blue) using native sequence and tetramer oligomerization as input parameters. (G–J). Overlay of each variant residue comparing crystal structure (yellow) positions to AlphaFold three predictions (blue). (K). Global root-mean-square-deviation (RMSD) values for each structure and model in relation to crystal structure KatASS1 chain A.

🚨 Postdoc Opportunity – Rutgers University! Join Ann Stock’s lab to study how Bacteroides regulate fiber and glycan metabolism via hybrid two-component systems. Structural + regulatory biology | CryoEM, crystallography, gene regulation 🔗 Apply | 🔬 Lab 📧 stock@cabm.rutgers.edu #postdoc #microsky 🧪🦠