A closer look at brain tissue vulnerability in neurological disease

New evidence explains differences in brain tissue vulnerability using animal models of human spinocerebellar ataxia type 1.

blogs.bcm.edu

Human Exposure to Spirochete-Infected Ornithodoros turicata in a Residential Setting in the Austin, Texas Metropolitan Area

Abstract. A central Texas resident found an engorged Ornithodoros turicata tick attached to their ankle while at home. The tick tested positive for Borreli

academic.oup.com

Bacteria share proteins to survive antibiotics

Researchers found that some bacteria share proteins that help others survive antibiotics.

nih.gov

Breakthrough Elephant Vaccine Shows First Signs of Protection Against Deadly Virus, The Houston Zoo

Newly published studies from Baylor College of Medicine and Houston Zoo provide the first evidence that an experimental EEHV vaccine may help protect young Asian elephants from severe disease. After m...

houstonzoo.org

New imaging tools to listen in on the brain’s ‘electrical whispers’

These biosensors make previously undetectable signals visible, opening new possibilities for studying how neural circuits process information.

blogs.bcm.edu

Elephant vaccine shows first signs of protection against deadly virus

After more than 15 years of collaborative research, Baylor College of Medicine (BCM) and Houston Zoo have reached a major milestone in the fight against...

bcm.edu

Extending genome-wide association studies to admixed cohorts with high degrees of relatedness - Nature Genetics

Tractor-Mix is a GWAS method for admixed cohorts with high relatedness, improving ancestry-specific effect estimation, controlling false positives and boosting power to detect ancestry-enriched loci a...

nature.com

Researchers uncovered a novel pathway that causes epilepsy

The findings also provide a new approach to improve the diagnosis of epilepsy, for which a genetic cause cannot be found in about 50 % of individuals with the condition.

blogs.bcm.edu

Researchers explain differences in brain tissue vulnerability in neurological disease

Many neurological diseases damage specific parts of the brain, even though the harmful protein involved is present throughout the brain. Researchers at...

bcm.edu

<fc>JAK</fc> Inhibition in <fc><fi>PNPT1</fi></fc>‐Related Mitochondrial Interferonopathy: A Case Report and Review of Mitochondrial–Immune Crosstalk

Biallelic pathogenic variants in PNPT1 cause combined oxidative phosphorylation deficiency 13 (COXPD13) (MIM #614932), linking mitochondrial dysfunction to type I interferon (IFN) activation through ...

onlinelibrary.wiley.com

Turning the tables on chemotherapy resistance: LIG1 loss exposes a therapeutic vulnerability in triple-negative breast cancer

The team identified underlying molecular mechanisms of platinum resistance that they neutralized with combinations of available drugs to reduce tumor growth in animal models.

blogs.bcm.edu

Baylor College of Medicine Research Contributes to FDA Approval of First Oral PCSK9 Inhibitor

Baylor College of Medicine researchers played a key role in the clinical development of the first oral PCSK9 inhibitor approved by the U.S. Food and Drug...

bcm.edu

TRISH calls for innovations to better understand venous thromboembolism in space

The Translational Research Institute for Space Health is seeking proposals to address venous thromboembolism, a critical risk to human health during spaceflight.

blogs.bcm.edu

BCM, TCH research recognized with prestigious Burroughs Wellcome Fund award

The award supports research on the molecular and cellular mechanisms involved with rare genetic disorders that affect immune defense.

blogs.bcm.edu

Researchers uncovered a novel pathway that causes epilepsy

Researchers have uncovered a novel biological pathway that can lead to seizures when disrupted. The findings also provide a new approach to improve...

bcm.edu

Turning the tables on chemotherapy resistance: LIG1 loss exposes a therapeutic vulnerability in triple-negative breast cancer

Loss of one copy of the DNA Ligase I (LIG1) gene in triple-negative breast cancers (TNBC) with TP53 mutations confers resistance to chemotherapy, but researchers...

bcm.edu

Genome editing in rats enables more accurate ER+ breast cancer models

This method is easily adaptable to other organs and can be used by researchers to develop their own cancer models.

blogs.bcm.edu

Scientists catch bacteria sharing proteins to survive antibiotics

Bacteria send protein packages to dormant neighbors to endure antibiotic attack

scientificamerican.com

OBGYN

Introduction While antibiotics have been shown to increase the interval to delivery between rupture of membranes and delivery (latency) and improve neonatal outcomes after viable preterm prelabor ru...

obgyn.onlinelibrary.wiley.com

Genome editing in rats enables more accurate ER+ breast cancer models

This method is easily adaptable to other organs and can be used by researchers to develop their own cancer models.

blogs.bcm.edu

Teamwork: An unexpected strategy bacteria use to survive antibiotics

The findings help explain why some bacteria are hard to eliminate and suggest potential future approaches to improve antibiotic effectiveness.

blogs.bcm.edu

Scientists discover how the brain represents meaning across different languages

The findings may help explain how people can effortlessly translate thoughts between languages without confusing them.

blogs.bcm.edu

Bacteria Share Proteins to Fight Off Antibiotics | The Scientist

Bacteria can pass proteins between themselves, which induces a dormant state that helps a small group of them survive antibiotics, revealing a path to better antibiotics.

the-scientist.com

How neutrophils help triple-negative breast cancer cells spread to other organs

The researchers found that the interaction between neutrophils and epithelial-like cancer cells helps both types of cells survive.

blogs.bcm.edu