Tessera
Folgen

Belen Pachano

@belenpachano.bsky.social

MSCA postdoctoral researcher studying Trypanosoma in the Siegel lab 🧬 From 🇦🇷 → 🇫🇷 → 🇩🇪

10 Posts164 Follower307 Folgt
Belen Pachano@belenpachano.bsky.social · 4w ago

Excited to share our new work in @natcomms.nature.com on GCN5b in Toxoplasma gondii! 🧬🦠 Huge thanks to everyone who contributed to this work! Specially Dominique and the amazing @hakimi.bsky.social 🎉 www.nature.com/articles/s41...

Divergent SAGA complexes shape the Toxoplasma transcriptome for lytic cycle progression and host interaction - Nature Communications

Researchers show that the zoonotic parasite Toxoplasma gondii built a unique chromatin modifying complex to activate the genes that drive infection and virulence, revealing a potential weak spot for n...

nature.com

Mohamed-Ali HAKIMI@hakimi.bsky.social · 4w ago

Toxoplasma didn't inherit SAGA from us 🧬 it rebuilt it from a 🌱 plant blueprint. Evolution loves a remix. Huge congrats to Dominique Cannella, an outstanding CNRS assistant engineer et al. www.nature.com/articles/s41... @cnrsbiologie.bsky.social @inserm.fr @agencerecherche.bsky.social

Divergent SAGA complexes shape the Toxoplasma transcriptome for lytic cycle progression and host interaction - Nature Communications

Researchers show that the zoonotic parasite Toxoplasma gondii built a unique chromatin modifying complex to activate the genes that drive infection and virulence, revealing a potential weak spot for n...

nature.com

Biomedical Center Munich / LMU Munich@bmc-lmu.bsky.social · 7mo ago

👏 @belenpachano.bsky.social from @siegel-lab.bsky.social has been awarded the Marie Skłodowska-Curie Actions (MSCA) fellowship @ec.europa.eu . 👏 She investigates how #pathogens evade the #host #immune #system through #antigenic #variation. ➡️ www.med.lmu.de/bmc/en/news/... 📸: Siegel Lab

European MSCA Fellowship Supports Research in the Siegel Lab

Dr Belén Pachano, postdoctoral researcher in the Siegel Lab, has been awarded the prestigious European Marie Skłodowska-Curie Actions (MSCA) fellowship.

med.lmu.de

Mohamed-Ali HAKIMI@hakimi.bsky.social · 11mo ago

Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto www.nature.com/articles/s41...

Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications

Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...

nature.com

Belen Pachano@belenpachano.bsky.social · last yr.

I’m excited to share our new preprint! We’ve been investigating a specific domain in TgSNF2L that forms decamers in vitro. Every time we attempted to break them apart, they just snapped back together. That tenacity earned it the nickname Hydra. 🐉 🔗 www.biorxiv.org/content/10.1...

Hydra domain drives SNF2L multimerization and marks ISWI diversification in parasites

ISWI chromatin remodelers are conserved regulators of nucleosome positioning and chromatin accessibility across eukaryotes, yet their evolutionary diversification is poorly understood. In the apicompl...

biorxiv.org

Belen Pachano@belenpachano.bsky.social · last yr.

Thrilled to share our latest review! 🎉 It captures the ideas and discussions that have shaped our work in recent years. Big shoutout to the amazing authors 👏 @hakimi.bsky.social www.sciencedirect.com/science/arti...

Decoding the epigenetic blueprint behind Toxoplasma (pre)sexual commitment and chronic persistence

Toxoplasma gondii, a widespread apicomplexan parasite, navigates a complex life cycle in which it switches back and forth between tachyzoites and brad…

sciencedirect.com

Belen Pachano@belenpachano.bsky.social · last yr.

Glad to have contributed to this amazing work out now in @embomolmed.org ! 🎉 Big shoutout to Marie G. Robert & Christopher Swale and @hakimi.bsky.social ! www.embopress.org/doi/full/10....

Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine

imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...

embopress.org

Mohamed-Ali HAKIMI@hakimi.bsky.social · last yr.

🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇 doi.org/10.1038/s443...

Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine

imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...

doi.org

LabEx ParaFrap@parafrap.bsky.social · last yr.

An ISWI-related chromatin remodeller regulates stage-specific gene expression in #Toxoplasma gondii. By Belen Pachano (ParaFrap PhD student) et al., team @hakimi.bsky.social. In @natmicrobiol.nature.com www.nature.com/articles/s41...

An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii - Nature Microbiology

Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...

nature.com

Belen Pachano@belenpachano.bsky.social · last yr.

Thrilled to share my first paper, now out in @natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work! www.nature.com/articles/s41...

An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii - Nature Microbiology

Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...

nature.com

Mohamed-Ali HAKIMI@hakimi.bsky.social · last yr.

In the silence of chromatin, Toxoplasma whispers change. TgSNF2h sculpts the genome - MORC in the backseat. Some genes wake. Others sleep. A dance of nucleosomes shaping space for life parasite stages to unfold. Now in Nature Microbiology: rdcu.be/ehkWp

An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii

Nature Microbiology - Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures...

rdcu.be