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Ben Parker Lab

@benparkerlab.bsky.social

Scientist @UniMelb 🇦🇺 focusing on #proteomics, signaling and metabolism. Loves 🏄‍♂️⛷️⛰️

30 Posts164 Follower174 Folgt
Ben Parker Lab@benparkerlab.bsky.social · 6mo ago

This is an important letter! We often do ‘omics analysis and each of the 1000’s of analytes measured has its own power calculation which is impossible to predict.

Abigail Mackey@abigailmackey1.bsky.social · 6mo ago

We wrote this letter to address the overly rigid preregistration requirements imposed now by many journals on exploratory experimental physiology research - time to align guidelines with contemporary research methods! @ismcopenhagen.bsky.social @proferichter.bsky.social doi.org/10.1113/EP09...

Ben Parker Lab@benparkerlab.bsky.social · 6mo ago

Our #phosphoproteomics analysis of insulin signaling in bone uncovered a new mechanism of transcriptional activation via S6K phosphorylation of AFF4. It appears to play a role in regulating the expression of genes in ageing and insulin resistance. www.nature.com/articles/s41...

Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator - Nature Communications

Insulin signaling plays a crucial role in coordinating skeletal development with whole‑body energy metabolism. Here, the authors use phosphoproteomics to show insulin-signaling rewiring in aged, insul...

nature.com

Ben Parker Lab@benparkerlab.bsky.social · 7mo ago

Protein:protein interactions are incredibly dynamic so how do we quantify and discover changes in native tissues? Our new study uses qXL-MS and PCP-MS to study dynamic remodeling of interactions following skeletal muscle insulin resistance. #MyoBlue #Proteomics www.biorxiv.org/content/10.6...

Quantitative interactome mapping of skeletal muscle insulin resistance

Protein-protein interactions (PPIs) are dynamic and critical to adaptive homeostasis. While there have been massive efforts to catalogue proteome-wide PPIs, global quantification of changes remains a ...

biorxiv.org

Komander Lab@komanderlab.bsky.social · last yr.

Two weeks to go before the abstract deadline (July 18th)! Looking forward to seeing you all there!

Rashmi Agrata@rashmiagrata.bsky.social · last yr.

Australia’s First Ubiquitin Summit is here! 🥳 📍Lorne, Victoria | 🗓️ 20–23 November 2025 Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics

Ben Parker Lab@benparkerlab.bsky.social · last yr.

Are you interested in #proteomics and #skeletalmuscle? It can be a real pain to get deep reproducible coverage. Check out our review with @adeshmukh.bsky.social We analyse some considerations including current limitations and how to potentially overcome them #myoblue @unimelbcmr.bsky.social

Skeletal muscle proteomics: considerations and opportunities

npj Metabolic Health and Disease - Skeletal muscle proteomics: considerations and opportunities

nature.com

Ben Parker Lab@benparkerlab.bsky.social · last yr.

Check out our new #proteomic method to site-specifically quantify UFMylation! We applied the approach to look at human skeletal muscle biopsies from #ALS. A great collaboration with CellSignalTechnology and many others... A little summary below... www.cell.com/cell-reports...

Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS

UFMylation is the post-translational modification of Ubiquitin Fold Modifier1 (UFM1) applied to substrate proteins. Blazev et al. develop an antibody-based enrichment approach followed by LC-MS/MS to ...

cell.com

Alexey Nesvizhskii@nesvilab.bsky.social · last yr.

Exciting news: We have released #FragPipe 23, and it's one of our biggest updates ever. Windows installer, support for TMT on Astral and timsTOF, TMT35, PTM site reports for DIA, improved Astral data handling in #MSFragger, improved diaTracer for diaPASEF data, better Skyline integration, and more!

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The Castiglione Lab @ Vanderbilt@castiglionelab.bsky.social · last yr.

Our newest paper is out in Science! This riddle took 5 years to solve. Genome annotation and AI missed it. Manual inspection and serendipity still have advantages for cracking nature's secrets! With @science.org @evolutionvu.bsky.social @rokaslab.bsky.social www.science.org/doi/10.1126/...

Running a genetic stop sign accelerates oxygen metabolism and energy production in horses

Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...

science.org

Ben Parker Lab@benparkerlab.bsky.social · last yr.

Hi #proteomics people, I'm hoping someone can help interpret these results. We have generated .fasta from RNAseq. We are testing the effects of different db size on min score cut-off @ 1% FDR. Hypothesis: as db increase, score increases. We don't see this with multiple algorithms and appears random.

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