NoPro-clipping: a new @komanderlab.bsky.social nanoflow LC-MS/MS workflow from @marcojochem.bsky.social et al. using an Aurora® Elite™ 15×75 column + Orbitrap Eclipse, Vanquish Neo detects ubiquitination of glycogen, glycerol & spermine in cells & tissues via targeted PRM. Learn more: bit.ly/3PYs222

This week #JournalClub @labsoap.bsky.social @embojournal.org @komanderlab.bsky.social #ubiquitin #DUB #USP9X link.springer.com/article/10.1...

Global analysis of cancer cell responses to USP9X inhibition - The EMBO Journal

The ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppres...

link.springer.com

WEHI researchers have found glycogen can be directly regulated using ubiquitin, in landmark findings published in Nature. The study transforms understanding into glycogen metabolism & could lead to new treatments for diseases caused by abnormal sugar storage. www.wehi.edu.au/news/sweet-d... 🧵1/2

Check out our latest paper on the ubiquitination of glycogen in cells and tissues! Congratulations to Marco Jochem (@marcojochem.bsky.social) and Simon Cobbold for leading this study and to collaborators @craigagoodman1.bsky.social, @pgregorevic.bsky.social, Kai Hofmann and Thomas Hermanns.

Marco Jochem@marcojochem.bsky.social · 3mo ago

Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...

Out now! The latest paper from the lab, spearheaded by Philipp Schenk, describing a new USP9X inhibitor with a unique DUB binding site.

The EMBO Journal@embojournal.org · 4mo ago

USP9X: understanding its cell-type-specific deubiquitination targets & mitotic arrest phenotypes in cancer cells Broad cancer cell-line screen by Philipp Schenk et al @komanderlab.bsky.social @wehi-research.bsky.social upon treatment with next-gen inhibitor WEHI-092 link.springer.com/article/10.1...

Congratulations Jake @mediocre-jake.bsky.social, Bekky Feltham and team on their phenomenal effort in putting together the E3-ome, published in Cell www.cell.com/cell/fulltex.... An extremely valuable resource for ubiquitin researchers.

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented know...

cell.com

WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · 5mo ago

WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field. Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social www.wehi.edu.au/news/new-enz...

After a long (but fun!) postdoc journey, I am very excited to share that I will start my own lab in the Ubiquitin Signalling Division at WEHI. We will study how ubiquitin controls mitochondrial health and its role in neurodegenerative disease. Hiring soon!

WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · 6mo ago

Say hello to our incoming lab heads! 👋 Excited to announce Dr Danika Hill, Dr Jacki Heraud-Farlow and Dr Sylvie Callegari will soon be establishing new labs at WEHI. More info: www.wehi.edu.au/news/excepti... bsky.app/profile/sylv... bsky.app/profile/jack... bsky.app/profile/prec...

A big year for the lab! We hosted Australia’s first ubiquitin summit in Lorne, Published the structure of PINK1 on a mitochondrial translocase array, Reported a new PLpro inhibitor for long COVID, Celebrated 3 PhD and 1 honours completions, Went on a lab footy trip, 🏈 Won the Eureka prize!! 🏆

It’s hard to believe that #AusUb2025 has already come to an end 😢. Don’t worry though - we’ll still be posting our speaker interviews in the next couple of days. Here’s what Sonja Lorenz thought of the Australian Ubiquitin Summit. 👇

Today we have Brenda Schulman, Director of the Department of Molecular Machines and Signalling at Max Planck Institute of Biochemistry, as our interviewee at #AusUb2025. Jump in to find out her research focus and conference tips!

‼️Have a listen to a little about Kylie Walter’s exciting new research, conference talk, and her experience at #AusUb2025. What did she enjoy most about the conference? More interviews to come in the next week so stay tuned 😁

‼️It was wonderful to have Professor Kay Hoffmann at the #AusUb25 - and even better to get the chance to interview him! Hear about his experiences in industry and academia as well as his love for proteins😁

‼️ Following on from our “M1 chains everywhere!” session at #AusUb25 we took the chance to interview one of the pioneering researchers in this field, Kazuhiro Iwai. Have a look below! ✨✨✨

‼️Towards the end of #AusUb25, we caught up with Jonathan Pruneda to discuss ubiquitin signalling and its relationship with host-pathogen interactions. It was an amazing conference and such a great chance to meet people from across the ubiquitin field 🤩

‼️For our final invited speaker interview, we talked with the amazing Titia Sixma about her work on the role of ubiquitin in DNA regulation, and some #AusUb2025 highlights. Thank you to everyone who came, it was an amazing conference and a great chance to see the breadth of global ubiquitin research!

Is there any biomolecule thats not #Ubiquitinated ? 🫣 It was super fun to chair my fav session on 'Ubiquitinating EVERYthing' during the kickstart event of #AusUb2025

The Australian Ubiquitin Summit@ausub.bsky.social · 9mo ago

#AusUb25 kicked off with an amazing session on ‘Ubiquitinating Things’. Thank you to all speakers: Brenda Schulman, Jonathan Pruneda, Satpal Virdee, Andrii Gorelik, and Yukiko Yoshida!

Today is the day! The Inaugural Australian Ubiquitin Summit #AusUb2025 was officially opened by committee chair David Komander.

Really excited for the first Australian Ubiquitin Summit starting tomorrow! Some of us got an early start at ISA11 Lorne. Awesome presentations from @simoncobb.bsky.social, Laura Fielden and @sylviecallegari.bsky.social See you in Lorne! @ausub.bsky.social

⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?). More interviews to come in the next few days so watch this space 😉

Stay tuned for some ✨exclusive✨ interviews from our organising committee members (including committee chair David Komander!).

Looking forward to seeing everyone in Lorne!! Only three weeks to go!

The Australian Ubiquitin Summit@ausub.bsky.social · 9mo ago

📢 All ubiquitin aficionados! 📢 We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️ Are you ready for talking ubiquitin by the bay? 🗓️ 20-23 Nov 📍Mantra, Lorne, VIC Chaired by David Komander (@komanderlab.bsky.social) #AusUb2025

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social. Excited for the awards ceremony on Sept 3rd! @eurekaprizes.bsky.social @wehi-research.bsky.social

PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research

YouTube video by Australian Museum

youtube.com

📣📣 Abstract deadline extension to Friday 1st August 📣📣 If you missed the last deadline, then don't miss out again!! Join us for sun, surf and ubiquitin in November at Lorne, Australia.

Grateful for the support from the Parkinson's Research Foundation!

WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · last yr.

WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s. Read more👇 www.wehi.edu.au/news/new-par...

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org #ubiquitin

Two weeks to go before the abstract deadline (July 18th)! Looking forward to seeing you all there!

Rashmi Agrata@rashmiagrata.bsky.social · last yr.

Australia’s First Ubiquitin Summit is here! 🥳 📍Lorne, Victoria | 🗓️ 20–23 November 2025 Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics

Excited to share our latest work, now out in @lsajournal.org. we show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.

Life Science Alliance@lsajournal.org · last yr.

The RBR E3 ligase HOIL-1 ubiquitinates Ser/Thr-residues and various disaccharides in vitro and can be used to generate ubiquitinated sugars as tools to study non-proteinaceous ubiquitination @lechtenberglab.bsky.social @wehi-research.bsky.social www.life-science-alliance.org/content/8/6/...

Could this breakthrough research lead to the first treatment for #longCOVID? A world-first milestone made possible through the advanced technologies of the National Drug Discovery Centre. Find out more: www.wehi.edu.au/news/tacklin...