Congratulations to Jessenya Mil and Jose Soto on their published paper, online now!! We are so excited that this is out! www.cell.com/cell/fulltex...

Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions

The developing human cortex is composed of diverse cell types, but how nutrient metabolism shapes their fate has remained unclear. This study maps the metabolic landscape of the developing human corte...

cell.com

@bhadurilab.bsky.social · last yr.

Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. www.biorxiv.org/content/10.1...

🌡️ HOTT isn't just about temperature. Human Organoid Tumor Transplantation (HOTT) is one of the models Dr. Bhaduri's lab (@bhadurilab.bsky.social) developed to understand how interactions with #glioblastoma tissue and immune cells contribute to therapy failure. #Neuroskyence @dgsomucla.bsky.social

Lab-grown organoids reveal how glioblastoma outsmarts treatment

Tumor organoid models offer new insight into how the brain and immune system shape cancer behavior.

uclahealth.org

(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.1...

🧵Excited to share our new preprint introducing iHOTT - an autologous tumor-immune co-culture model that captures patient-specific responses in #Glioblastoma 💥Now on @biorxivpreprint : biorxiv.org/content/10.1... Led by Dr. Shivani Baisiwala, Neurosurgery Resident in the lab

Excited to present our new preprint led by @claudianguyen95 uncovering how thalamic input shapes human cortical development! We discover that thalamic axons promote the generation of upper layer cortical neurons through NRXN1-mediated contacts with outer radial glia. www.biorxiv.org/content/10.1...

Congratulations @prnano9.bsky.social!!! We are thrilled that this paper is out and hope everyone enjoys using the datasets and meta-atlas tools!!

Patricia Nano@prnano9.bsky.social · last yr.

It’s out! The first paper from my postdoc – and first from the @bhadurilab.bsky.social – is now live @natneuro.nature.com . 🧠✨ Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)

Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. www.biorxiv.org/content/10.1...

Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions

Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic pr...

biorxiv.org

It’s good to be in California these days. Come join us! We’ve got an open post-doc position funded by CA institute for regenerative medicine. It’s a big multi-disciplinary team science project led by @bhadurilab.bsky.social. Organoid transplants, neuro development, 2P! bri.ucla.edu/open-positio...

Thank you to the @uclastemcell.bsky.social for their unwavering support and for this piece on our lab!

UCLA Broad Stem Cell Research Center@uclastemcell.bsky.social · last yr.

Member Spotlight: Meet Dr. Aparna Bhaduri, a neuroscientist whose work bridges human brain development and cancer research. Here, she shares how she uses “mini brain” organoids in her lab, what drives her curiosity and her passion for rock climbing. ucla.in/3CMa9g4