www.nature.com/articles/s41... Beautiful work 👏👏

Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication - Nature Communications

Virus-induced cellular condensates are poorly understood. Using cryoET and cryoEM, the authors visualized the 3D “molecular sociology” of host-virus interactions and choreographed mammalian reovirus a...

nature.com

I was still thinking about the quantum computing stocks and now we already have drug discovery pipeline with quantum computing algorithms 🙄🙄 These days I feel impossible to catch up with the pace of structural biology and drug discovery www.nature.com/articles/s41... 👏👏

Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors - Nature Biotechnology

A hybrid model combines quantum and classical approaches to generate compounds targeting the KRAS protein.

nature.com

It was an amazing line up of speakers at the Cryo-EM: the next 50 years symposium. Meeting the pioneers in person and gaining insights for the future in CryoEM was the highlight of this meeting 👏

Nogales Lab@nogaleslab.bsky.social · 2y ago

The Cryo-EM: the next 50 years Symposium held yesterday at @ucberkeleyofficial.bsky.social was a smashing success!!

I think I can be rationally optimistic about 2025 😇🫶 This week so far is incredibly fruitful 🙏 This one thrown first time on grid and the protein complex is already screaming for data collection 🤞😎😇 P.S. - ignore the aggregates, we can deal with those later #SPA #cryoem

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

In my role at Stanford, I wear many hats 🕵️‍♂️, but the most fulfilling of all is training and making the cutting edge tech accessible. Seeing my trainees/collaborators push boundaries in science is truly fulfilling and their kind words make me feel genuinely appreciated! Remembering teaching days. ❄️🔬☃️

Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍 Shimakawa et al: www.cell.com/cell/fulltex... Nam et al: www.cell.com/cell/fulltex... @biozentrum.bsky.social press release: www.biozentrum.unibas.ch/news/detail/... Read on for more... 1/🧵

Just so proud of seeing these skinny babies at the end of long tedious sessions #waffleMilling #teamtomo It was my personal goal to learn FIB-SEM this year. A super kind researcher trusted and collaborated and gave me a driving force 🙏 this is where I am in 4th session on this sample. More to go

Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells https://www.biorxiv.org/content/10.1101/2024.11.18.624098v1

Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells https://www.biorxiv.org/content/10.1101/2024.11.18.624098v1

Fragile X Messenger Ribonucleoprotein 1 (FMRP) is a multifunctional, multidomain RNA-binding protein

biorxiv.org

Excited to share the collaboration project with Rohatgi lab at Stanford, recently published in Science www.science.org/doi/10.1126/...

Regulated N-glycosylation controls chaperone function and receptor trafficking

One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeepin...

science.org