🎉 Congrats to Scott Fraser, Biohub’s President of Dynamic Imaging, on receiving the Microscopy Society of America’s Distinguished Scientist Award - Biological Sciences, in recognition of his transformative contributions in bioimaging and molecular analysis!

Preprint: biorxiv.org/content/10.6... This is the product of many years of effort, and particularly amazing summer teamwork by Qi Yu, Haedong Kim, @seidels.bsky.social @cxqiu.bsky.social and many others from Shendure Lab & SeaHub (a @alleninstitute.org @biohub.org @uwmedicine.bsky.social colab) 2/n

In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis

The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...

biorxiv.org

How hard was it to get the laser phase plate to work? Like “trying to hit a bullet with a bullet” hard, says Biohub scientist David Agard. Check out the latest episode of the Uncovered podcast from @cenmag.bsky.social.

C&EN (Chemical & Engineering News)@cenmag.bsky.social · 2w ago

Learn about a device that boosts the contrast in electron microscopy using the most intense laser beam yet made, and the story of its path from an idea to an invention that could open new lines of inquiry in structural biology and biochemistry. #chemsky 🧪

Can science give you superpowers? Don’t miss Biohub Investigators @profhernandez.bsky.social and KC Huang at San Diego Comic-Con tonight! #SDCC

Christopher J Hernandez@profhernandez.bsky.social · 3w ago

I’m excited about my upcoming talk at San Diego Comic Con in a panel entitled “How science may give you superpowers” with KC Huang and Tom Galloway. #SDCC #Makeitcannon #Originstory www.comic-con.org/cc/things-to...

🚨 New preprint: We reprocessed 77k zebrafish RNA-seq datasets from across the global research community and found hidden viruses in 10% of them—including a fish virus whose proteins are 91% identical to human Influenza B—then built a generalizable pipeline. bit.ly/4vxFF72

7.5M people in the U.S. live with psoriasis. Many still struggle despite treatment. Our team combined AI + CRISPR to find overlooked biological pathways — then tested an existing asthma drug. It worked. This is frontier AI and frontier biology working together. 🧬 Learn more: bit.ly/44QSiyW

A Genome-Wide CRISPR Screen Reveals New Psoriasis Targets

Biohub researchers combined a genome-wide CRISPR screen with AI to uncover an unexpected psoriasis drug target: the receptor for oxytocin.

bit.ly

Excited to be at #ICML 2026! We’ll share three papers on virtual cell modeling, single-cell data generation, and immune recognition. → Virtual Cells Need Context, Not Just Scale icml.cc/virtual/2026... → scLDM icml.cc/virtual/2026... → DecoderTCR icml.cc/virtual/2026...

🎉Congrats to the Remoscope team, 1st place winner of the Medical Device category of the Nebius AI Discovery Awards! Developed at Biohub, Remoscope is an AI-powered diagnostic platform that can rapidly image and analyze blood and other biological fluids to diagnose disease.

The deadline for this funding opportunity is fast approaching: applications are due July 16!

Biohub@biohub.org · 2mo ago

Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ

How do you track thousands of cells in complex systems, in 3D & over time? We are launching a Kaggle challenge to push the frontier of AI-powered cell tracking, building on advances like Ultrack & the DaXi lightsheet microscope from the @loicaroyer.bsky.social lab. bit.ly/4bfdzWE

1/ 🧬🔬 How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇 www.kaggle.com/competitions... @biohub.org

What happens when physicists turn their tools on living systems? That's the question at the heart of the Physics of Life Symposium—and this year marks its fifth edition. Submit an abstract or register to attend by Aug. 14: bit.ly/4xJIPH7

The 2nd Chicago BioEngineering Conference (CBEC) is back — Sept. 17–18 in downtown Chicago! 🧬 Omics. Bioelectronics. AI × bio. A stellar speaker lineup. Two days of science that matters. Space is limited → register now: bit.ly/4vqlXLj

Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...

Phase contrast enables structures of smaller proteins, could drive in-cell proteomics: cen.acs.org/analytical-c... #chemsky 🧪

“The laser phase plate has the highest continuous light intensity in the solar system, outside of the inner regions of the Sun,” says physicist Holger Müller. Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...

15 years, flawless mirrors, and the brightest laser in the world: How physicists brought phase contrast to cryo-EM

Phase contrast enables structures of smaller proteins, could drive in-cell proteomics

cen.acs.org

Check out Alex Rives on Latent Space discussing the science behind ESMFold2, ESMC, and ESM Atlas, and what a world model of protein biology actually makes possible. 🎙️ https://bit.ly/4vwqLy3

The laser phase plate is leveling up cryoEM so we can see biology like never before. Learn more: bit.ly/4vK9LVn

met a grad student in Holger’s lab and asked him about his research. my jaw was on the floor about halfway through and he just kept piling on to the bonkers scope and challenge. This project is so insanely cool and ambitious.

Biohub@biohub.org · 2mo ago

In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn

In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn

Dubbed a “Swiss army knife” for biological imaging, MOSAIC’s development was led by Biohub Investigator @supgokul.bsky.social of @ucberkeleyofficial.bsky.social . Learn more about the microscope, and the “AI mind” he’s creating to make sense of all the data ⤵️

Hi-res microscopes give biologists petabytes of data. Scientists are creating an AI assistant to make sense of it. - Berkeley News

At UC Berkeley, high-resolution microscopes are generating images of cells and embryos day and night, collecting massive amounts of data to train an AI model for living biological systems.

news.berkeley.edu

Nature Methods@natmethods.nature.com · 3mo ago

MOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @supgokul.bsky.social www.nature.com/articles/s41...

Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ

📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬 Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std? The answer surprised us 🧵 www.biorxiv.org/content/10.6...

👀🔥 @nature.com on why releasing ESMFold2, ESMC, and ESM Atlas openly changes what's possible for the research community

Nature@nature.com · 2mo ago

A newly released AI tool has generated an atlas of more than one billion predicted protein structures and billions more protein sequences. go.nature.com/4wS3Pen

A newly released AI tool has generated an atlas of more than one billion predicted protein structures and billions more protein sequences. go.nature.com/4wS3Pen

Move over, AlphaFold: open source model predicts shape of 1 billion proteins

The new open-source atlas, generated by an AI tool called ESMFold2, vastly increases the known protein universe.

go.nature.com

Proteins are the machinery of life. Billions of their sequences have been cataloged—but the biology behind most is still unknown. Today we're releasing ESMFold2, ESMC and ESM Atlas to help change that. Open source, open to every scientist. biohub.ai/esm/protein

Inflammation drives nearly every major disease—cancer, heart disease, and autoimmune conditions. Yet we've never been able to watch it progress in living tissue. We're funding 15 projects to build real-time molecular tools to change that. Learn more ➡️ bit.ly/4wFDJej

New in @natbiotech.nature.com from Aly Khan: a platform combining yeast display with fine-tuned protein language models to identify antigens driving autoimmune disease. In collaboration with Chris Garcia at @stanfordpress.bsky.social / @hhmi-science.bsky.social 🧵

Datasets of recognition profiles for individual TCRs vs millions of peptides offers a scalable approach to mapping TCR recognition, accelerating antigen discovery and guiding TCR engineering @stanforduniversity.bsky.social @biohub.org #Garcia @natbiotech.nature.com www.nature.com/articles/s41...

Great to see Biohub's investment in the future of AI and cell biology with its 5-year Virtual Biology Initiative programme. Beautiful alignment with the roadmap for HCA 2.0, and lots of excitement about future synergies.

Biohub@biohub.org · 3mo ago

Today we're announcing the Virtual Biology Initiative—a major new commitment to build the data foundation biology needs to power the next generation of AI models. Next-gen imaging. Molecular engineering tools. Open data infrastructure for the entire scientific community. Read more: bit.ly/3ONTkHO